diff --git a/Src/Base/AMReX_GpuContainers.H b/Src/Base/AMReX_GpuContainers.H
index 3825bbd4de3..fc04651a165 100644
--- a/Src/Base/AMReX_GpuContainers.H
+++ b/Src/Base/AMReX_GpuContainers.H
@@ -129,11 +129,7 @@ namespace amrex::Gpu {
 
         auto size = std::distance(begin, end);
         if (size == 0) { return; }
-#ifdef AMREX_USE_GPU
         htod_memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#else
-        std::memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#endif
     }
 
     /**
@@ -166,11 +162,7 @@ namespace amrex::Gpu {
 
         auto size = std::distance(begin, end);
         if (size == 0) { return; }
-#ifdef AMREX_USE_GPU
         dtoh_memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#else
-        std::memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#endif
     }
 
     /**
@@ -203,11 +195,7 @@ namespace amrex::Gpu {
 
         auto size = std::distance(begin, end);
         if (size == 0) { return; }
-#ifdef AMREX_USE_GPU
         dtod_memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#else
-        std::memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#endif
     }
 
     /**
@@ -241,11 +229,7 @@ namespace amrex::Gpu {
 
         auto size = std::distance(begin, end);
         if (size == 0) { return; }
-#ifdef AMREX_USE_GPU
         htod_memcpy_async(&(*result), &(*begin), size*sizeof(value_type));
-#else
-        std::memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#endif
     }
 
     /**
@@ -279,11 +263,7 @@ namespace amrex::Gpu {
 
         auto size = std::distance(begin, end);
         if (size == 0) { return; }
-#ifdef AMREX_USE_GPU
         dtoh_memcpy_async(&(*result), &(*begin), size*sizeof(value_type));
-#else
-        std::memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#endif
     }
 
     /**
@@ -317,11 +297,7 @@ namespace amrex::Gpu {
 
         auto size = std::distance(begin, end);
         if (size == 0) { return; }
-#ifdef AMREX_USE_GPU
         dtod_memcpy_async(&(*result), &(*begin), size*sizeof(value_type));
-#else
-        std::memcpy(&(*result), &(*begin), size*sizeof(value_type));
-#endif
     }
 
     /**
diff --git a/Src/Base/AMReX_GpuDevice.H b/Src/Base/AMReX_GpuDevice.H
index eb2b95943e7..847e5923c35 100644
--- a/Src/Base/AMReX_GpuDevice.H
+++ b/Src/Base/AMReX_GpuDevice.H
@@ -289,6 +289,31 @@ dtod_memcpy_async (void* p_d_dst, const void* p_d_src, const std::size_t sz) noe
 #endif
 }
 
+#else // AMREX_USE_GPU
+
+inline void
+htod_memcpy_async (void* p_d, const void* p_h, const std::size_t sz) noexcept
+{
+    if (sz == 0) { return; }
+    std::memcpy(p_d, p_h, sz);
+}
+
+inline void
+dtoh_memcpy_async (void* p_h, const void* p_d, const std::size_t sz) noexcept
+{
+    if (sz == 0) { return; }
+    std::memcpy(p_h, p_d, sz);
+}
+
+inline void
+dtod_memcpy_async (void* p_d_dst, const void* p_d_src, const std::size_t sz) noexcept
+{
+    if (sz == 0) { return; }
+    std::memcpy(p_d_dst, p_d_src, sz);
+}
+
+#endif // AMREX_USE_GPU
+
 inline void
 htod_memcpy (void* p_d, const void* p_h, const std::size_t sz) noexcept
 {
@@ -313,8 +338,6 @@ dtod_memcpy (void* p_d_dst, const void* p_d_src, const std::size_t sz) noexcept
     Gpu::streamSynchronize();
 }
 
-#endif
-
 #ifdef AMREX_USE_HYPRE
 void hypreSynchronize ();
 #endif
diff --git a/Src/FFT/AMReX_FFT_OpenBCSolver.H b/Src/FFT/AMReX_FFT_OpenBCSolver.H
index e54aedb0a8e..0cd881ac2bf 100644
--- a/Src/FFT/AMReX_FFT_OpenBCSolver.H
+++ b/Src/FFT/AMReX_FFT_OpenBCSolver.H
@@ -143,12 +143,7 @@ void OpenBCSolver<T>::setGreensFunction (F const& greens_function)
         if (srcfab) {
             auto* dstfab = detail::get_fab(m_G_fft);
             if (dstfab) {
-#if defined(AMREX_USE_GPU)
-                Gpu::dtod_memcpy_async
-#else
-                std::memcpy
-#endif
-                    (dstfab->dataPtr(), srcfab->dataPtr(), dstfab->nBytes());
+                Gpu::dtod_memcpy_async(dstfab->dataPtr(), srcfab->dataPtr(), dstfab->nBytes());
             } else {
                 amrex::Abort("FFT::OpenBCSolver: how did this happen");
             }
diff --git a/Src/FFT/AMReX_FFT_R2C.H b/Src/FFT/AMReX_FFT_R2C.H
index 72560bfc2c7..d4eb5ff7b39 100644
--- a/Src/FFT/AMReX_FFT_R2C.H
+++ b/Src/FFT/AMReX_FFT_R2C.H
@@ -976,23 +976,15 @@ void R2C<T,D,C>::forward (RT const* in, CT* out)
     auto [cdata, csz] = install_raw_ptr(m_raw_cmf, out);
 
     if (rsz > 0) {
-#ifdef AMREX_USE_GPU
         Gpu::dtod_memcpy_async(rdata.get(),in,rsz);
         Gpu::streamSynchronize();
-#else
-        std::memcpy(rdata.get(),in,rsz);
-#endif
     }
 
     forward(m_raw_mf, m_raw_cmf);
 
     if (csz) {
-#ifdef AMREX_USE_GPU
         Gpu::dtod_memcpy_async(out,cdata.get(),csz);
         Gpu::streamSynchronize();
-#else
-        std::memcpy(out,cdata.get(),csz);
-#endif
     }
 }
 
@@ -1075,23 +1067,15 @@ void R2C<T,D,C>::backward (CT const* in, RT* out)
     auto [cdata, csz] = install_raw_ptr(m_raw_cmf, in);
 
     if (csz) {
-#ifdef AMREX_USE_GPU
         Gpu::dtod_memcpy_async(cdata.get(),in,csz);
         Gpu::streamSynchronize();
-#else
-        std::memcpy(cdata.get(),in,csz);
-#endif
     }
 
     backward(m_raw_cmf, m_raw_mf);
 
     if (rsz > 0) {
-#ifdef AMREX_USE_GPU
         Gpu::dtod_memcpy_async(out,rdata.get(),rsz);
         Gpu::streamSynchronize();
-#else
-        std::memcpy(out,rdata.get(),rsz);
-#endif
     }
 }
 
diff --git a/Src/LinearSolvers/AMReX_AlgVector.H b/Src/LinearSolvers/AMReX_AlgVector.H
index f2cb7b45b17..348e3b7d585 100644
--- a/Src/LinearSolvers/AMReX_AlgVector.H
+++ b/Src/LinearSolvers/AMReX_AlgVector.H
@@ -171,11 +171,7 @@ void AlgVector<T,Allocator>::copyAsync (AlgVector<T> const& rhs)
     AMREX_ASSERT(m_data.size() == rhs.m_data.size());
     T* dst = m_data.data();
     T const* src = rhs.data();
-#ifdef AMREX_USE_GPU
     Gpu::dtod_memcpy_async(dst, src, n*sizeof(T));
-#else
-    std::memcpy(dst, src, n*sizeof(T));
-#endif
 }
 
 template <typename T, typename Allocator>
diff --git a/Src/Particle/AMReX_NeighborList.H b/Src/Particle/AMReX_NeighborList.H
index 6233a41002a..a656281e3ce 100644
--- a/Src/Particle/AMReX_NeighborList.H
+++ b/Src/Particle/AMReX_NeighborList.H
@@ -322,11 +322,7 @@ public:
 
         // Get tot bin count on host
         int tot_bins;
-#ifdef AMREX_USE_GPU
         Gpu::dtoh_memcpy( &tot_bins, off_bins_p + num_bin_types, sizeof(int) );
-#else
-        std::memcpy( &tot_bins, off_bins_p + num_bin_types, sizeof(int) );
-#endif
 
         m_bins.build(np_total, pstruct_ptr, tot_bins, bm);
 
@@ -397,11 +393,7 @@ public:
 
         // Now we can allocate and build our neighbor list
         unsigned int total_nbors;
-#ifdef AMREX_USE_GPU
         Gpu::dtoh_memcpy(&total_nbors,m_nbor_offsets.dataPtr()+np_size,sizeof(unsigned int));
-#else
-        std::memcpy(&total_nbors,m_nbor_offsets.dataPtr()+np_size,sizeof(unsigned int));
-#endif
 
         m_nbor_list.resize(total_nbors);
         auto* pm_nbor_list = m_nbor_list.dataPtr();
diff --git a/Src/Particle/AMReX_NeighborParticlesI.H b/Src/Particle/AMReX_NeighborParticlesI.H
index aaf3bb54381..a85a9faf7a7 100644
--- a/Src/Particle/AMReX_NeighborParticlesI.H
+++ b/Src/Particle/AMReX_NeighborParticlesI.H
@@ -936,19 +936,11 @@ buildNeighborList (CheckPair const& check_pair, int type_ind, int* ref_ratio,
                 auto dxInv = lgeom.InvCellSizeArray();
                 auto ploa  = lgeom.ProbLoArray();
 
-#ifdef AMREX_USE_GPU
                 Gpu::htod_memcpy_async( dxi_v.data()   + type, dxInv.data(), sizeof(dxInv) );
                 Gpu::htod_memcpy_async( plo_v.data()   + type, ploa.data() , sizeof(ploa) );
                 Gpu::htod_memcpy_async( lo_v.data()    + type, &lo         , sizeof(lo)    );
                 Gpu::htod_memcpy_async( hi_v.data()    + type, &hi         , sizeof(hi)    );
                 Gpu::htod_memcpy_async( nbins_v.data() + type, &nbins      , sizeof(nbins) );
-#else
-                std::memcpy( dxi_v.data()   + type, dxInv.data(), sizeof(dxInv) );
-                std::memcpy( plo_v.data()   + type, ploa.data() , sizeof(ploa)  );
-                std::memcpy( lo_v.data()    + type, &lo         , sizeof(lo)    );
-                std::memcpy( hi_v.data()    + type, &hi         , sizeof(hi)    );
-                std::memcpy( nbins_v.data() + type, &nbins      , sizeof(nbins) );
-#endif
             }
 
             Gpu::exclusive_scan(nbins_v.begin(), nbins_v.end(), off_bins_v.begin());
diff --git a/Tests/EB_CNS/Exec/Combustor/cns_prob.cpp b/Tests/EB_CNS/Exec/Combustor/cns_prob.cpp
index c48fc4fc72c..d0f72ee517f 100644
--- a/Tests/EB_CNS/Exec/Combustor/cns_prob.cpp
+++ b/Tests/EB_CNS/Exec/Combustor/cns_prob.cpp
@@ -21,12 +21,8 @@ extern "C" {
         pp.query("interior_T" , CNS::h_prob_parm->interior_T);
         pp.query("interior_P" , CNS::h_prob_parm->interior_p);
 
-#ifdef AMREX_USE_GPU
         // Cannot use Gpu::copy because ProbParm is not trivailly copyable.
         Gpu::htod_memcpy_async(CNS::d_prob_parm, CNS::h_prob_parm, sizeof(ProbParm));
-#else
-        std::memcpy(CNS::d_prob_parm, CNS::h_prob_parm, sizeof(ProbParm));
-#endif
 
         Gpu::HostVector<Real> inflow_state(CNS::numState());