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pko-base.obo
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format-version: 1.2
data-version: http://si.eu-parc.eu//pko/releases/2023-11-13/pko-base.owl
ontology: http://si.eu-parc.eu//pko/pko-base.owl
property_value: http://purl.org/dc/elements/1.1/type IAO:8000001
property_value: http://purl.org/dc/terms/description "None" xsd:string
property_value: http://purl.org/dc/terms/license https://creativecommons.org/licenses/unspecified
property_value: http://purl.org/dc/terms/title "pharmokinetic-ontology" xsd:string
property_value: owl:versionInfo "2023-11-13" xsd:string
[Term]
id: PKO:0000000
name: root node
[Term]
id: PKO:0000004
name: Physiologically Based Pharmacokinetic Modeling
def: "Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique that predicts the absorption, distribution, metabolism, and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species" [] {IAO:0000119="10.1038/psp.2013.41"}
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "PBPK" xsd:string
[Term]
id: PKO:0000005
name: Whole body PBPK Model
def: "A whole-body PBPK model contains an explicit representation of the organs that are most relevant to the absorption, distribution, excretion, and metabolization of the drug/chemicals due to their physiological/pharmacological function or their volume" [] {IAO:0000119="10.1002/psp4.12134"}
is_a: PKO:0000004 ! Physiologically Based Pharmacokinetic Modeling
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "All organs PBPK" xsd:string
[Term]
id: PKO:0000006
name: Perfusion Limited Model
def: "Perfusion-limited models are a type of physiologically based pharmacokinetic (PBPK) model that assumes that the concentration of a substance in tissues reaches equilibrium with the substance in the circulation rapidly. In perfusion-limited models, the rate of drug uptake by tissues is limited by blood flow, and the rate of drug elimination is limited by the rate of diffusion from the tissue to the blood" [] {IAO:0000119="https://doi.org/10.3390/nano10071267"}
is_a: PKO:0000004 ! Physiologically Based Pharmacokinetic Modeling
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000007
name: Physiological Parameters
def: "Physiological parameters in PBPK modeling provide the structural framework of the model and are used to simulate the absorption, distribution, metabolism, and excretion (ADME) of a substance throughout the body. These parameters include body weight, height, organ volume, cardiac output, organ blood flow, and tissue composition." [] {IAO:0000119="10.3390/ijerph20043473"}
is_a: PKO:0000006 ! Perfusion Limited Model
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000008
name: Body Mass Index
def: "An individual's weight in kilograms divided by the square of the height in meters." [] {IAO:0000119="http://purl.obolibrary.org/obo/NCIT_C16358"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "BMI" xsd:string
[Term]
id: PKO:0000009
name: BW (Kg)
def: " Mass or quantity of heaviness of an individual. " [] {IAO:0000119="http://purl.bioontology.org/ontology/MESH/D001835"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "BW" xsd:string
[Term]
id: PKO:0000010
name: HT
def: "Height is a term used to describe the distance from the bottom to the top of someone or something standing upright" [] {IAO:0000119="Height Definition & Meaning - Merriam-Webster"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "HT" xsd:string
[Term]
id: PKO:0000011
name: Surface area
def: " A measure of total area i.e., surface of object occupies. or\n \nThe two dimensional measure of the outer layer of the body." [] {IAO:0000119="http://semanticscience.org/resource/SIO_001407\n\nhttp://purl.bioontology.org/ontology/MESH/D001830"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "BSA/SA" xsd:string
[Term]
id: PKO:0000012
name: Race
def: "A geographic ancestral origin category assigned to a population group ." [] {IAO:0000119="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17049"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000013
name: Blood flow
def: "Blood flow in PBPK modeling refers to the rate of blood flow to a particular organ or tissue, which is used to calculate the rate of drug delivery to that organ or tissue/chemical" [] {IAO:0000119="10.1002/psp4.12134"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "Q" xsd:string
[Term]
id: PKO:0000014
name: Cardiac Output
def: "Cardiac output in PBPK modeling refers to the volume of blood pumped by the heart per unit of time, which is used to calculate the rate of blood flow to different organs and tissues in the body" [] {IAO:0000119="10.3390/ijerph20043473"}
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "CO" xsd:string
[Term]
id: PKO:0000015
name: Qstomach
def: "Qstomach is a parameter used in PBPK modeling to describe the blood flow rate to the stomach, which is used to calculate the rate of drug/chemical delivery to the stomach. The value of Qstomach depends on the species of interest and is defined by the stomach weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000016
name: FQstomach
def: "Fraction of blood flow to stomach" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000015 ! Qstomach
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000017
name: Qintestine
def: "Qintestine is a parameter used in PBPK modeling to describe the blood flow rate to the intestine, which is used to calculate the rate of drug/chemical delivery to the intestine. The value of Qintestine depends on the species of interest and is defined by the intestine weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000018
name: FQintestine
def: "Fraction of blood flow to intestine" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000017 ! Qintestine
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000019
name: Qsmall intestine
def: "Qsmall intestine is a parameter used in PBPK modeling to describe the blood flow rate to the small intestine, which is used to calculate the rate of drug/chemical delivery to the small intestine. The value of Qsmall intestine depends on the species of interest and is defined by the small intestine weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000020
name: FQsmall intestine
def: "Fraction of blood flow to small intestine" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000019 ! Qsmall intestine
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000021
name: Qlarge intestine
def: "Qlarge intestine is a parameter used in PBPK modeling to describe the blood flow rate to the large intestine, which is used to calculate the rate of drug/chemical delivery to the large intestine. The value of Qlarge intestine depends on the species of interest and is defined by the large intestine weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000022
name: FQlarge intestine
def: "Fraction of blood flow to large intestine" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000021 ! Qlarge intestine
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000023
name: Qpancreas
def: "Qpancreas is a parameter used in PBPK modeling to describe the blood flow rate to the pancreas, which is used to calculate the rate of drug/chemical delivery to the pancreas. The value of Qpancreas depends on the species of interest and is defined by the pancreas weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000024
name: FQpancreas
def: "Fraction of blood flow to pancreas" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000023 ! Qpancreas
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000025
name: Qliver
def: "Qliver is a parameter used in PBPK modeling to describe the blood flow rate to the liver, which is used to calculate the rate of drug/chemical delivery to the liver. The value of Qliver depends on the species of interest and is defined by the liver weight/volume and cardiac output" [] {IAO:0000119="10.1002/psp4.12134\nhttps://www.ema.europa.eu/en/documents/scientific-guideline/guideline-reporting-physiologically-based-pharmacokinetic-pbpk-modelling-simulation_en.pdf"}
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000026
name: FQliver
def: "Fraction of blood flow to liver" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000025 ! Qliver
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000027
name: Qkidney
def: "Qkidney is a parameter used in PBPK modeling to describe the blood flow rate to the kidney, which is used to calculate the rate of drug/chemical delivery to the kidney. The value of Qkidney depends on the species of interest and is defined by the kidney weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000028
name: FQkidney
def: "Fraction of blood flow to kidney" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000027 ! Qkidney
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000029
name: Qmuscle
def: "Qmuscle is a parameter used in PBPK modeling to describe the blood flow rate to the muscle, which is used to calculate the rate of drug/chemical delivery to the muscle. The value of Qmuscle depends on the species of interest and is defined by the muscle weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000030
name: FQmuscle
def: "Fraction of blood flow to muscle" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000029 ! Qmuscle
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000031
name: Qheart
def: "Qheart is a parameter used in PBPK modeling to describe the blood flow rate to the heart, which is used to calculate the rate of drug/chemical delivery to the heart. The value of Qheart depends on the species of interest and is defined by the heart weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000032
name: FQheart
def: "Fraction of blood flow to heart" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000031 ! Qheart
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000033
name: Qfat
def: "Qfat is a parameter used in PBPK modeling to describe the blood flow rate to the fat, which is used to calculate the rate of drug/chemical delivery to the fat. The value of Qfat depends on the species of interest and is defined by the fat weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "Qadipose tissue" xsd:string
[Term]
id: PKO:0000034
name: FQfat
def: "Fraction of blood flow to fat" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000033 ! Qfat
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000035
name: Qgonads
def: "Qgonads is a parameter used in PBPK modeling to describe the blood flow rate to the gonads, which is used to calculate the rate of drug/chemical delivery to the gonads. The value of Qgonads depends on the species of interest and is defined by the gonads weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000036
name: FQgonads
def: "Fraction of blood flow to gonads" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000035 ! Qgonads
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000037
name: Qskin
def: "Qskin is a parameter used in PBPK modeling to describe the blood flow rate to the skin, which is used to calculate the rate of drug/chemical delivery to the skin. The value of Qskin depends on the species of interest and is defined by the skin weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000038
name: FQskin
def: "Fraction of blood flow to skin" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000037 ! Qskin
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000039
name: Qbone
def: "Qbone is a parameter used in PBPK modeling to describe the blood flow rate to the bone, which is used to calculate the rate of drug/chemical delivery to the bone. The value of Qbone depends on the species of interest and is defined by the bone weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000040
name: FQbone
def: "Fraction of blood flow to bone" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000039 ! Qbone
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000041
name: Qbrain
def: "Qbrain is a parameter used in PBPK modeling to describe the blood flow rate to the brain, which is used to calculate the rate of drug/chemical delivery to the brain. The value of Qbrain depends on the species of interest and is defined by the brain weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000042
name: FQbrain
def: "Fraction of blood flow to brain" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000041 ! Qbrain
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000043
name: Qspleen
def: "Qspleen is a parameter used in PBPK modeling to describe the blood flow rate to the spleen, which is used to calculate the rate of drug/chemical delivery to the spleen. The value of Qspleen depends on the species of interest and is defined by the spleen weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000044
name: FQspleen
def: "Fraction of blood flow to spleen" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000043 ! Qspleen
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000045
name: Qlung
def: "Qlung is a parameter used in PBPK modeling to describe the blood flow rate to the lung, which is used to calculate the rate of drug/chemical delivery to the lung. The value of Qlung depends on the species of interest and is defined by the lung weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000046
name: FQlung
def: "Fraction of blood flow to lung" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000045 ! Qlung
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000047
name: Qpoorly perfused
def: "Qpoorly perfused is a parameter used in PBPK modeling to describe the blood flow rate to the poorly perfused organ/tissue, which is used to calculate the rate of drug/chemical delivery to the poorly perfused organ/tissue. The value of Qpoorly perfused depends on the species of interest and is defined by the poorly perfused organ/tissue weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000048
name: FQpoorly perfused
def: "Fraction of blood flow to poorly perfused tissues/organ" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000047 ! Qpoorly perfused
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000049
name: Qrichly perfused
def: "Qrichly perfused is a parameter used in PBPK modeling to describe the blood flow rate to the richly perfused organ/tissue, which is used to calculate the rate of drug/chemical delivery to the richly perfused organ/tissue. The value of Qrichly perfused depends on the species of interest and is defined by the richly perfused organ/tissue weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000050
name: FQrichly perfused
def: "Fraction of blood flow to richly perfused tissues/organs" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000049 ! Qrichly perfused
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000051
name: Qrestbody
def: "Qrestbody is a parameter used in PBPK modeling to describe the blood flow rate to the remaining organ/tissue, which is used to calculate the rate of drug/chemical delivery to the remaining organ/tissue. The value of Qrestbody can be obtained by subtracting the total body blood flow with the blood flow of each organs/tissue present in the model." []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000052
name: FQrestbody
is_a: PKO:0000051 ! Qrestbody
[Term]
id: PKO:0000053
name: Qgallballder
def: "Qgall bladder is a parameter used in PBPK modeling to describe the blood flow rate to the gall bladder, which is used to calculate the rate of drug/chemical delivery to the gall bladder. The value of Qgall bladder depends on the species of interest and is defined by the gall bladder weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000054
name: FQgallballder
is_a: PKO:0000053 ! Qgallballder
[Term]
id: PKO:0000055
name: Qportal vein
def: "Qportal vein is a parameter used in PBPK modeling to describe the blood flow rate to the portal vein, which is used to calculate the rate of drug/chemical delivery to the stomach. The value of Qportal vein depends on the species of interest and is defined by the portal vein weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000056
name: FQportal vein
is_a: PKO:0000055 ! Qportal vein
[Term]
id: PKO:0000057
name: Qlymph
def: "Qlymph is a parameter used in PBPK modeling to describe the blood flow rate to the lymph, which is used to calculate the rate of drug/chemical delivery to the lymph. The value of Qlymph depends on the species of interest and is defined by the lymph weight/volume and cardiac output" []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000058
name: FQlymph
is_a: PKO:0000057 ! Qlymph
[Term]
id: PKO:0000059
name: Arterial blood flow
def: "Arterial blood flow in PBPK modeling represents the rate of blood flow to the tissues and organs through the arterial system. This parameter is essential for estimating the distribution of drugs and other substances in the body" [] {IAO:0000119="10.1007/s40268-020-00325-0\n10.1186/1472-6904-4-2"}
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000060
name: Venous blood flow
def: "Venous blood flow in PBPK modeling represents the rate of blood flow returning from the tissues and organs through the venous system. This parameter is essential for estimating the distribution of drugs/chemicals and other substances in the body." []
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000061
name: Glomerular filtration rate
def: "Glomerular filtration rate (GFR) is a measure of kidney function that describes the flow rate of filtered fluid through the kidney" [] {IAO:0000119="Glomerular filtration rate - Wikipedia"}
is_a: PKO:0000013 ! Blood flow
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "GFR" xsd:string
[Term]
id: PKO:0000062
name: Volume of organ
def: "Organ volume in PBPK modeling refers to the volume of a specific organ or tissue in the body. " [] {IAO:0000119="10.1002/psp4.12205"}
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "Vorgan" xsd:string
[Term]
id: PKO:0000063
name: Vstomach
def: "Volume of stomach" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000064
name: Fstomach
def: "stomach volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000063 ! Vstomach
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000065
name: Vintestine
def: "Volume of intestine" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000066
name: Fintestine
def: "intestine volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000065 ! Vintestine
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000067
name: Vsmall intestine
def: "Volume of small intestine" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000068
name: Fsmall intestine
def: "small intestine volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000067 ! Vsmall intestine
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000069
name: Vlarge intestine
def: "Volume of large intestine" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000070
name: Flarge intestine
def: "large intestine volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000069 ! Vlarge intestine
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000071
name: Vpancreas
def: "Volume of pancreas" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000072
name: Fpancreas
def: "pancreas volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000071 ! Vpancreas
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000073
name: Vliver
def: "Volume of liver" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000074
name: Fliver
def: "liver volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000073 ! Vliver
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000075
name: Vkidney
def: "Volume of kidney" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000076
name: Fkidney
def: "kidney volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000075 ! Vkidney
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000077
name: Vmuscle
def: "Volume of muscle" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000078
name: Fmuscle
def: "muscle volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000077 ! Vmuscle
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000079
name: Vheart
def: "Volume of heart" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000080
name: Fheart
def: "heart volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000079 ! Vheart
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000081
name: Vfat
def: "Volume of fat" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000082
name: Ffat
def: "fat volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000081 ! Vfat
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000083
name: Vgonads
def: "Volume of gonads" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000084
name: Fgonads
def: "gonads volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000083 ! Vgonads
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000085
name: Vskin
def: "Volume of skin" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000086
name: Fskin
def: "skin volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000085 ! Vskin
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000087
name: Vbone
def: "Volume of bone" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000088
name: Fbone
def: "bone volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000087 ! Vbone
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000089
name: Vbrain
def: "Volume of brain" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000090
name: Fbrain
def: "brain volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000089 ! Vbrain
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000091
name: Vspleen
def: "Volume of spleen" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000092
name: Fspleen
def: "spleen volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000091 ! Vspleen
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000093
name: Vlung
def: "Volume of lung" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000094
name: Flung
def: "lung volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000093 ! Vlung
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000095
name: Vpoorly perfused
def: "Volume of poorly perfused tissue/organ" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000096
name: Fpoorly perfused
def: "poorly perfused tissues/organs volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000095 ! Vpoorly perfused
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000097
name: Vrichly perfused
def: "Volume of richly perfused tissue/organ" [] {IAO:0000119="https://doi.org/10.1016/j.envres.2022.114074"}
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000098
name: Frichly perfused
def: "richly perfused tissues/organs volume as total body weight fraction" [] {IAO:0000119="https://doi.org/10.1016/j.toxlet.2023.06.006"}
is_a: PKO:0000097 ! Vrichly perfused
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000099
name: Vplasma
def: "Volume of the plasma" []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000100
name: Fplasma
is_a: PKO:0000099 ! Vplasma
[Term]
id: PKO:0000101
name: Vrestbody
def: "Volume of the restbody" []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000102
name: Frestbody
is_a: PKO:0000101 ! Vrestbody
[Term]
id: PKO:0000103
name: vgallbaldder
def: "Volume of the gallbaldder " []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000104
name: Fgallbladder
is_a: PKO:0000103 ! vgallbaldder
[Term]
id: PKO:0000105
name: vportal vein
def: "Volume of the portal vein" []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000106
name: Fportal vein
is_a: PKO:0000105 ! vportal vein
[Term]
id: PKO:0000107
name: vlymph
def: "Volume of the lymph" []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000108
name: Flymph
is_a: PKO:0000107 ! vlymph
[Term]
id: PKO:0000109
name: Arterial volume
def: "Volume of the Arteries" []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000110
name: venous volume
def: "Volume of the veins" []
is_a: PKO:0000062 ! Volume of organ
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000111
name: Sex
def: "Characteristics totality of reproductive structure, functions, PHENOTYPE, GENOTYPE to differentiate MALE from FEMALE organism" []
is_a: PKO:0000007 ! Physiological Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000112
name: Male
def: "Males, as sex i,e. produces smaller gametes (e.g. sperm)" [] {IAO:0000119="https://sci-hub.se/https://doi.org/10.1093/molehr/gau068"}
is_a: PKO:0000111 ! Sex
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "M" xsd:string
[Term]
id: PKO:0000113
name: Female
def: "Females, as sex i,e. produces gamete dimorphism (anisogamy)" [] {IAO:0000119="https://sci-hub.se/https://doi.org/10.1093/molehr/gau069"}
is_a: PKO:0000111 ! Sex
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "F" xsd:string
[Term]
id: PKO:0000114
name: Physicochemical Parameters
def: "Physicochemical parameters of a compound include molecular weight (MW), lipophilicity, solubility, and pKa values, which can usually be determined in vitro. The physicochemical properties of a compound are used to parameterize the PBPK model" [] {IAO:0000119="10.3390/ijerph20043473\nhttps://cot.food.gov.uk/sites/default/files/2021-01/TOX-2019-34%20PBPK%20used%20for%20human%20health%20risk%20assessment.pdf"}
is_a: PKO:0000004 ! Physiologically Based Pharmacokinetic Modeling
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000115
name: Molecular weights
def: "Sum of weight of all the atoms in a molecule." [] {IAO:0000119="http://purl.bioontology.org/ontology/MESH/D008970"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "MW" xsd:string
[Term]
id: PKO:0000116
name: Molecular weights
def: "Sum of weight of all the atoms in a molecule." [] {IAO:0000119="http://purl.bioontology.org/ontology/MESH/D008970"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "MW" xsd:string
[Term]
id: PKO:0000117
name: Lipophillicity
def: " Affinity of a molecule or a moiety\nfor a lipophilic environment " [] {IAO:0000119="https://sci-hub.se/10.1016/j.microc.2019.01.030"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000118
name: Distribution coefficients\n (Log D)
def: "LogD distribution constant, better descriptor of lipophilicity of a molecule." [] {IAO:0000119="https://doi.org/10.3109/00498258809041669\nhttps://pubs.acs.org/doi/abs/10.1021/jm00211a010"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "Log D" xsd:string
[Term]
id: PKO:0000119
name: Log P
def: " Ratio of a dissolved xenoboitic substance in a two-phase system. " [] {IAO:0000119="https://doi.org/10.3109/00498258809041669\nhttps://pubs.acs.org/doi/abs/10.1021/jm00211a010\nhttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20610"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000120
name: Log S
def: "Xenoboitic Solubility unit corresponding to 10-based logarithm measured in mol/L. or\nlog (solubility measured in mol/l)." [] {IAO:0000119="https://dev.Xenoboiticbank.com/guides/terms/log-s\nhttps://docs.chemaxon.com/display/docs/theory-of-aqueous-solubility-prediction.md"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000121
name: Water solubility
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000122
name: pka (strongest acidic)
def: "Negative base-10 logarithm of acid dissociation constant (Ka) of a solution" [] {IAO:0000119="http://semanticscience.org/resource/CHEMINF_000195\nhttps://dev.Xenoboiticbank.com/guides/terms/pka"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "pka" xsd:string
[Term]
id: PKO:0000123
name: pkb (strongest basic)
def: "Negative base-10 logarithm of base dissociation constant (Ka) of a solution" [] {IAO:0000119="https://uts.nlm.nih.gov/uts.html\nhttp://www.semanticweb.org/ontologies/2010/3/Ontology1271664172453.owl#pKb"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "pKb pK(b) pK(B) affinity constant, Base dissociation constan" xsd:string
[Term]
id: PKO:0000124
name: physiological charge
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000125
name: Hydrogen acceptor count
def: "A descriptor reflects integer number of hydrogen bond acceptors in a given molecular entity." [] {IAO:0000119="http://purl.obolibrary.org/obo/CHEBI_13193\nhttp://semanticscience.org/resource/CHEMINF_000245"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
property_value: IAO:0000605 "A" xsd:string
[Term]
id: PKO:0000126
name: Hydrogen donor count
def: " \nA molecule can undergo oxidation by loss of hydrogen." [] {IAO:0000119="http://purl.obolibrary.org/obo/CHEBI_17499"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000127
name: rotable bond count
def: "An integer count of bonds in a given molecular entity" [] {IAO:0000119="http://semanticscience.org/resource/CHEMINF_000233"}
is_a: PKO:0000114 ! Physicochemical Parameters
property_value: IAO:0000117 "0000-0001-8345-1349" xsd:string
property_value: IAO:0000117 "0000-0002-9795-5967" xsd:string
[Term]
id: PKO:0000128
name: Biochemical Parameters
is_a: PKO:0000006 ! Perfusion Limited Model
[Term]