This repository is an update of the prostate model to version 2.2.3 of PhysiBoSS. The project does not rely on the cell rules to perform the inhibition, but on an ad-hoc cell sensitivity that depends on the cell line.
A prior version of this model was used to simulate the drug response in prostate cell lines in Figures 6, 7 and 8 of the PhysiBoSS 2.0 paper.
The XML in the config folder are:
- PhysiCell_settings_LNCaP.xml: LNCaP cell line simulation
- PhysiCell_settings_LNCaP_Luminespib_2.xml: LNCaP cell line simulation adding Luminespib drug (anti_HSPs).
- PhysiCell_settings_LNCaP_Pictilisib_2.xml: LNCaP cell line simulation adding Pictilisib drug (anti_PI3K).
- PhysiCell_settings_LNCaP_Luminespib_Pictilisib_2.xml: LNCaP cell line simulation adding Luminespib and Pictilisib drugs.
Files in the scripts folder have post processing scripts.
Arnau Montagud, Annika Meert, Gerard Pradas and Miguel Ponce de Leon, BSC-CNS
Contact: arnau.montagud at csic.es
The goal of this model is to study the different modes of cell migration and to predict means to block it by considering not only spatial information obtained from the agent-based simulation but also intracellular regulation obtained from the Boolean model.
The first version of this model was published in Multiscale model of the different modes of cancer cell invasion, Bioinformatics, June 2023. A follow up version was published in the PhysiBoSS tutorial Building multiscale models with PhysiBoSS, an agent-based modeling tool, Briefings in Bioinformatics, November 2024.