diff --git a/backend/internal/pkg/apicompat/chatcompletions_responses_test.go b/backend/internal/pkg/apicompat/chatcompletions_responses_test.go
index f54a4a027f..464c26efab 100644
--- a/backend/internal/pkg/apicompat/chatcompletions_responses_test.go
+++ b/backend/internal/pkg/apicompat/chatcompletions_responses_test.go
@@ -181,6 +181,50 @@ func TestChatCompletionsToResponses_ImageURL(t *testing.T) {
 	assert.Equal(t, "data:image/png;base64,abc123", parts[1].ImageURL)
 }
 
+func TestChatCompletionsToResponses_EmptyBase64ImageURLSkipped(t *testing.T) {
+	content := `[{"type":"text","text":"Describe this"},{"type":"image_url","image_url":{"url":"data:image/png;base64,"}}]`
+	req := &ChatCompletionsRequest{
+		Model: "gpt-4o",
+		Messages: []ChatMessage{
+			{Role: "user", Content: json.RawMessage(content)},
+		},
+	}
+	resp, err := ChatCompletionsToResponses(req)
+	require.NoError(t, err)
+
+	var items []ResponsesInputItem
+	require.NoError(t, json.Unmarshal(resp.Input, &items))
+	require.Len(t, items, 1)
+
+	var parts []ResponsesContentPart
+	require.NoError(t, json.Unmarshal(items[0].Content, &parts))
+	require.Len(t, parts, 1)
+	assert.Equal(t, "input_text", parts[0].Type)
+	assert.Equal(t, "Describe this", parts[0].Text)
+}
+
+func TestChatCompletionsToResponses_WhitespaceOnlyBase64ImageURLSkipped(t *testing.T) {
+	content := `[{"type":"text","text":"Describe this"},{"type":"image_url","image_url":{"url":"data:image/png;base64,   "}}]`
+	req := &ChatCompletionsRequest{
+		Model: "gpt-4o",
+		Messages: []ChatMessage{
+			{Role: "user", Content: json.RawMessage(content)},
+		},
+	}
+	resp, err := ChatCompletionsToResponses(req)
+	require.NoError(t, err)
+
+	var items []ResponsesInputItem
+	require.NoError(t, json.Unmarshal(resp.Input, &items))
+	require.Len(t, items, 1)
+
+	var parts []ResponsesContentPart
+	require.NoError(t, json.Unmarshal(items[0].Content, &parts))
+	require.Len(t, parts, 1)
+	assert.Equal(t, "input_text", parts[0].Type)
+	assert.Equal(t, "Describe this", parts[0].Text)
+}
+
 func TestChatCompletionsToResponses_SystemArrayContent(t *testing.T) {
 	req := &ChatCompletionsRequest{
 		Model: "gpt-4o",
diff --git a/backend/internal/pkg/apicompat/chatcompletions_to_responses.go b/backend/internal/pkg/apicompat/chatcompletions_to_responses.go
index 6cdd012a49..dc157a6d3c 100644
--- a/backend/internal/pkg/apicompat/chatcompletions_to_responses.go
+++ b/backend/internal/pkg/apicompat/chatcompletions_to_responses.go
@@ -339,7 +339,7 @@ func convertChatContentPartsToResponses(parts []ChatContentPart) []ResponsesCont
 				})
 			}
 		case "image_url":
-			if p.ImageURL != nil && p.ImageURL.URL != "" {
+			if p.ImageURL != nil && p.ImageURL.URL != "" && !isEmptyBase64DataURI(p.ImageURL.URL) {
 				responseParts = append(responseParts, ResponsesContentPart{
 					Type:     "input_image",
 					ImageURL: p.ImageURL.URL,
@@ -350,6 +350,22 @@ func convertChatContentPartsToResponses(parts []ChatContentPart) []ResponsesCont
 	return responseParts
 }
 
+func isEmptyBase64DataURI(raw string) bool {
+	if !strings.HasPrefix(raw, "data:") {
+		return false
+	}
+	rest := strings.TrimPrefix(raw, "data:")
+	semicolonIdx := strings.Index(rest, ";")
+	if semicolonIdx < 0 {
+		return false
+	}
+	rest = rest[semicolonIdx+1:]
+	if !strings.HasPrefix(rest, "base64,") {
+		return false
+	}
+	return strings.TrimSpace(strings.TrimPrefix(rest, "base64,")) == ""
+}
+
 func flattenChatContentParts(parts []ChatContentPart) string {
 	var textParts []string
 	for _, p := range parts {
diff --git a/backend/internal/service/openai_gateway_service.go b/backend/internal/service/openai_gateway_service.go
index 0a95961512..ff0a8968e9 100644
--- a/backend/internal/service/openai_gateway_service.go
+++ b/backend/internal/service/openai_gateway_service.go
@@ -1931,6 +1931,11 @@ func (s *OpenAIGatewayService) Forward(ctx context.Context, c *gin.Context, acco
 		}
 	}
 
+	if sanitizeEmptyBase64InputImagesInOpenAIRequestBodyMap(reqBody) {
+		bodyModified = true
+		disablePatch()
+	}
+
 	// Re-serialize body only if modified
 	if bodyModified {
 		serializedByPatch := false
@@ -2358,6 +2363,14 @@ func (s *OpenAIGatewayService) forwardOpenAIPassthrough(
 		reqStream = gjson.GetBytes(body, "stream").Bool()
 	}
 
+	sanitizedBody, sanitized, err := sanitizeEmptyBase64InputImagesInOpenAIBody(body)
+	if err != nil {
+		return nil, err
+	}
+	if sanitized {
+		body = sanitizedBody
+	}
+
 	logger.LegacyPrintf("service.openai_gateway",
 		"[OpenAI 自动透传] 命中自动透传分支: account=%d name=%s type=%s model=%s stream=%v",
 		account.ID,
@@ -4691,6 +4704,123 @@ func normalizeOpenAIServiceTier(raw string) *string {
 	}
 }
 
+func sanitizeEmptyBase64InputImagesInOpenAIBody(body []byte) ([]byte, bool, error) {
+	if len(body) == 0 || !bytes.Contains(body, []byte(`"image_url"`)) || !bytes.Contains(body, []byte(`base64,`)) {
+		return body, false, nil
+	}
+
+	var reqBody map[string]any
+	if err := json.Unmarshal(body, &reqBody); err != nil {
+		return body, false, fmt.Errorf("sanitize request body: %w", err)
+	}
+	if !sanitizeEmptyBase64InputImagesInOpenAIRequestBodyMap(reqBody) {
+		return body, false, nil
+	}
+	normalized, err := json.Marshal(reqBody)
+	if err != nil {
+		return body, false, fmt.Errorf("serialize sanitized request body: %w", err)
+	}
+	return normalized, true, nil
+}
+
+func sanitizeEmptyBase64InputImagesInOpenAIRequestBodyMap(reqBody map[string]any) bool {
+	if reqBody == nil {
+		return false
+	}
+	input, ok := reqBody["input"]
+	if !ok {
+		return false
+	}
+	normalizedInput, changed := sanitizeEmptyBase64InputImagesInOpenAIInput(input)
+	if !changed {
+		return false
+	}
+	reqBody["input"] = normalizedInput
+	return true
+}
+
+func sanitizeEmptyBase64InputImagesInOpenAIInput(input any) (any, bool) {
+	items, ok := input.([]any)
+	if !ok {
+		return input, false
+	}
+
+	normalizedItems := make([]any, 0, len(items))
+	changed := false
+	for _, item := range items {
+		itemMap, ok := item.(map[string]any)
+		if !ok {
+			normalizedItems = append(normalizedItems, item)
+			continue
+		}
+		if shouldDropEmptyBase64InputImagePart(itemMap) {
+			changed = true
+			continue
+		}
+		content, ok := itemMap["content"]
+		if !ok {
+			normalizedItems = append(normalizedItems, itemMap)
+			continue
+		}
+		parts, ok := content.([]any)
+		if !ok {
+			normalizedItems = append(normalizedItems, itemMap)
+			continue
+		}
+
+		normalizedParts := make([]any, 0, len(parts))
+		itemChanged := false
+		for _, part := range parts {
+			if shouldDropEmptyBase64InputImagePart(part) {
+				changed = true
+				itemChanged = true
+				continue
+			}
+			normalizedParts = append(normalizedParts, part)
+		}
+		if itemChanged {
+			if len(normalizedParts) == 0 {
+				continue
+			}
+			itemMap["content"] = normalizedParts
+		}
+		normalizedItems = append(normalizedItems, itemMap)
+	}
+	if !changed {
+		return input, false
+	}
+	return normalizedItems, true
+}
+
+func shouldDropEmptyBase64InputImagePart(part any) bool {
+	partMap, ok := part.(map[string]any)
+	if !ok {
+		return false
+	}
+	typeValue, _ := partMap["type"].(string)
+	if strings.TrimSpace(typeValue) != "input_image" {
+		return false
+	}
+	imageURL, _ := partMap["image_url"].(string)
+	return isEmptyBase64DataURI(imageURL)
+}
+
+func isEmptyBase64DataURI(raw string) bool {
+	if !strings.HasPrefix(raw, "data:") {
+		return false
+	}
+	rest := strings.TrimPrefix(raw, "data:")
+	semicolonIdx := strings.Index(rest, ";")
+	if semicolonIdx < 0 {
+		return false
+	}
+	rest = rest[semicolonIdx+1:]
+	if !strings.HasPrefix(rest, "base64,") {
+		return false
+	}
+	return strings.TrimSpace(strings.TrimPrefix(rest, "base64,")) == ""
+}
+
 func getOpenAIRequestBodyMap(c *gin.Context, body []byte) (map[string]any, error) {
 	if c != nil {
 		if cached, ok := c.Get(OpenAIParsedRequestBodyKey); ok {
diff --git a/backend/internal/service/openai_gateway_service_hotpath_test.go b/backend/internal/service/openai_gateway_service_hotpath_test.go
index f73c06c5e1..234dee00cf 100644
--- a/backend/internal/service/openai_gateway_service_hotpath_test.go
+++ b/backend/internal/service/openai_gateway_service_hotpath_test.go
@@ -1,6 +1,7 @@
 package service
 
 import (
+	"encoding/json"
 	"net/http/httptest"
 	"testing"
 
@@ -139,3 +140,61 @@ func TestGetOpenAIRequestBodyMap_WriteBackContextCache(t *testing.T) {
 	require.True(t, ok)
 	require.Equal(t, got, cachedMap)
 }
+
+func TestSanitizeEmptyBase64InputImagesInOpenAIRequestBodyMap(t *testing.T) {
+	var reqBody map[string]any
+	require.NoError(t, json.Unmarshal([]byte(`{
+		"model":"gpt-5.4",
+		"input":[
+			{"role":"user","content":[
+				{"type":"input_text","text":"Describe this"},
+				{"type":"input_image","image_url":"data:image/png;base64,   "},
+				{"type":"input_image","image_url":"data:image/png;base64,abc123"}
+			]},
+			{"role":"user","content":[
+				{"type":"input_image","image_url":"data:image/png;base64,"}
+			]},
+			{"type":"input_image","image_url":"data:image/png;base64,"},
+			{"type":"input_image","image_url":"data:image/png;base64,top-level-valid"}
+		]
+	}`), &reqBody))
+
+	require.True(t, sanitizeEmptyBase64InputImagesInOpenAIRequestBodyMap(reqBody))
+
+	normalized, err := json.Marshal(reqBody)
+	require.NoError(t, err)
+	require.JSONEq(t, `{
+		"model":"gpt-5.4",
+		"input":[
+			{"role":"user","content":[
+				{"type":"input_text","text":"Describe this"},
+				{"type":"input_image","image_url":"data:image/png;base64,abc123"}
+			]},
+			{"type":"input_image","image_url":"data:image/png;base64,top-level-valid"}
+		]
+	}`, string(normalized))
+}
+
+func TestSanitizeEmptyBase64InputImagesInOpenAIBody(t *testing.T) {
+	body, changed, err := sanitizeEmptyBase64InputImagesInOpenAIBody([]byte(`{
+		"model":"gpt-5.4",
+		"stream":true,
+		"input":[
+			{"role":"user","content":[
+				{"type":"input_text","text":"Describe this"},
+				{"type":"input_image","image_url":"data:image/png;base64,"}
+			]}
+		]
+	}`))
+	require.NoError(t, err)
+	require.True(t, changed)
+	require.JSONEq(t, `{
+		"model":"gpt-5.4",
+		"stream":true,
+		"input":[
+			{"role":"user","content":[
+				{"type":"input_text","text":"Describe this"}
+			]}
+		]
+	}`, string(body))
+}