diff --git a/.changeset/thick-spies-act.md b/.changeset/thick-spies-act.md
new file mode 100644
index 000000000..b0e5ec0c5
--- /dev/null
+++ b/.changeset/thick-spies-act.md
@@ -0,0 +1,5 @@
+---
+'@aws-amplify/data-schema': minor
+---
+
+add bedrock system cross-region inference profiles
diff --git a/packages/data-schema/src/ai/ModelType.ts b/packages/data-schema/src/ai/ModelType.ts
index fb4832f15..c8d383e61 100644
--- a/packages/data-schema/src/ai/ModelType.ts
+++ b/packages/data-schema/src/ai/ModelType.ts
@@ -26,6 +26,35 @@ const supportedModelsLookup = {
   'Mistral Large': 'mistral.mistral-large-2402-v1:0',
   'Mistral Large 2': 'mistral.mistral-large-2407-v1:0',
   'Mistral Small': 'mistral.mistral-small-2402-v1:0',
+
+  // Cross-region inference profiles
+
+  // us-east-1 us-west-2
+  'US Anthropic Claude 3 Sonnet': 'us.anthropic.claude-3-sonnet-20240229-v1:0',
+  'US Anthropic Claude 3 Opus': 'us.anthropic.claude-3-opus-20240229-v1:0',
+  'US Anthropic Claude 3 Haiku': 'us.anthropic.claude-3-haiku-20240307-v1:0',
+
+  // us-east-1 us-east-2 us-west-2
+  'US Anthropic Claude 3.5 Sonnet': 'us.anthropic.claude-3-5-sonnet-20240620-v1:0',
+  'US Anthropic Claude 3.5 Haiku': 'us.anthropic.claude-3-5-haiku-20241022-v1:0',
+  'US Anthropic Claude 3.5 Sonnet v2': 'us.anthropic.claude-3-5-sonnet-20241022-v2:0',
+  'US Anthropic Claude 3.7 Sonnet': 'us.anthropic.claude-3-7-sonnet-20250219-v1:0',
+
+  // us-east-1 us-east-2 us-west-2
+  'US Nova Lite': 'us.amazon.nova-lite-v1:0',
+  'US Nova Pro': 'us.amazon.nova-pro-v1:0',
+  'US Nova Micro': 'us.amazon.nova-micro-v1:0',
+
+  // eu-central-1 eu-west-1 eu-west-3
+  'EU Anthropic Claude 3 Sonnet': 'eu.anthropic.claude-3-sonnet-20240229-v1:0',
+  'EU Anthropic Claude 3.5 Sonnet': 'eu.anthropic.claude-3-5-sonnet-20240620-v1:0',
+  'EU Anthropic Claude 3 Haiku': 'eu.anthropic.claude-3-haiku-20240307-v1:0',
+
+  // ap-northeast-1 ap-northeast-2 ap-south-1 ap-southeast-1 ap-southeast-2
+  'APAC Anthropic Claude 3 Sonnet': 'apac.anthropic.claude-3-sonnet-20240229-v1:0',
+  'APAC Anthropic Claude 3.5 Sonnet': 'apac.anthropic.claude-3-5-sonnet-20240620-v1:0',
+  'APAC Anthropic Claude 3 Haiku': 'apac.anthropic.claude-3-haiku-20240307-v1:0',
+  'APAC Anthropic Claude 3.5 Sonnet v2': 'apac.anthropic.claude-3-5-sonnet-20241022-v2:0',
 } as const;
 
 export interface InferenceConfiguration {