diff --git a/.github/actions/docker-deploy/action.yml b/.github/actions/docker-deploy/action.yml index 32c2a77a..8fa71d15 100644 --- a/.github/actions/docker-deploy/action.yml +++ b/.github/actions/docker-deploy/action.yml @@ -151,7 +151,7 @@ runs: flags: | --add-cloudsql-instances ${{ inputs.deployment-sql-instance }} --vpc-connector ${{ inputs.deployment-vpc-connector }} - --vpc-egress all + --vpc-egress private-ranges-only --allow-unauthenticated --memory ${{ env.MEMORY }} --cpu ${{ env.CPU }} diff --git a/.github/actions/unit-tests/action.yml b/.github/actions/unit-tests/action.yml index f1f3ffa4..480239df 100644 --- a/.github/actions/unit-tests/action.yml +++ b/.github/actions/unit-tests/action.yml @@ -19,7 +19,7 @@ runs: shell: bash - name: Install Dependencies - run: poetry install --with dev,test + run: poetry install --with dev,test,scripts shell: bash - name: Run Linting diff --git a/.github/workflows/build-and-deploy-workflow.yml b/.github/workflows/build-and-deploy-workflow.yml new file mode 100644 index 00000000..2aaba3cd --- /dev/null +++ b/.github/workflows/build-and-deploy-workflow.yml @@ -0,0 +1,174 @@ +name: CAS Repository Build and Deploy Workflow +on: + workflow_dispatch: + inputs: + service-type: + description: 'Service type to build and deploy. Can be `compute`, `admin` or `both`. Default is `both`.' + required: false + default: 'both' + type: choice + options: + - both + - compute + - admin + image-tag: + description: 'Docker image tag. Will use the short hash of the last commit in the branch if nothing is passed in.' + required: false + default: '' + add-latest-tag: + description: 'Push a `latest` tag to the artifact registry. Default is `true`.' + required: false + default: true + type: boolean + deployment-prefix: + description: 'The prefix to add to the deployment names' + required: true + default: '' + service-account-email: + description: 'Service account email used as the identity for the deployment.' + required: true + default: '' + sql-instance: + description: 'The SQL instance to connect to in the form [project]:[region]:[instance]' + required: true + default: '' + vpc-connector: + description: 'The VPC connector to use for the deployment in the form projects/[project]/locations/[region]/connectors/[connector]' + required: true + default: '' + config-secret: + description: 'The Google secret to use for the deployment configuration in the form [secret-name]:[version (or "latest")]' + required: true + default: '' + region: + description: 'The region to deploy the image to' + required: false + default: 'us-central1' + flavor: + description: 'The nature of the deployment set. Configurations are set based on this value and the values can be configured in the deploy/cloudrun/{flavor}.json files.' + required: true + default: 'default' + +jobs: + + prepare: + name: Resolve Image Tag + runs-on: ubuntu-latest + outputs: + image-tag: ${{ steps.get-tag.outputs.tag }} + steps: + - uses: actions/checkout@v4 + + - id: get-tag + name: Get image tag + env: + IMAGE_TAG: ${{ inputs.image-tag }} + run: | + if [[ "$IMAGE_TAG" == "" ]]; then + echo "tag=$(git rev-parse --short HEAD)" >> $GITHUB_OUTPUT + else + echo "tag=$IMAGE_TAG" >> $GITHUB_OUTPUT + fi + shell: bash + + build-images: + name: Build Docker Images + needs: prepare + runs-on: ubuntu-latest + + permissions: + contents: write + id-token: write + + strategy: + matrix: + service-type: [ 'compute', 'admin' ] + + env: + DOCKER_REGISTRY_NAME: us-central1-docker.pkg.dev + COMPUTE_IMAGE_NAME: us-central1-docker.pkg.dev/${{ secrets.GCP_PROJECT_ID }}/cas-services-cicd/cas-compute + ADMIN_IMAGE_NAME: us-central1-docker.pkg.dev/${{ secrets.GCP_PROJECT_ID }}/cas-services-cicd/cas-admin + + steps: + - uses: actions/checkout@v4 + + - id: build-compute + uses: ./.github/actions/docker-build + if: matrix.service-type == 'compute' && (inputs.service-type == 'compute' || inputs.service-type == 'both') + with: + docker-registry-name: ${{ env.DOCKER_REGISTRY_NAME }} + image-name: ${{ env.COMPUTE_IMAGE_NAME }} + image-tag: ${{ needs.prepare.outputs.image-tag }} + service-type: ${{ matrix.service-type }} + gcp-provider-id: ${{ secrets.GCP_PROVIDER_ID }} + gcp-service-account-email: ${{ secrets.GCP_SERVICE_ACCOUNT_EMAIL }} + add-latest-tag: ${{ inputs.add-latest-tag }} + + - id: build-admin + uses: ./.github/actions/docker-build + if: matrix.service-type == 'admin' && (inputs.service-type == 'admin' || inputs.service-type == 'both') + with: + docker-registry-name: ${{ env.DOCKER_REGISTRY_NAME }} + image-name: ${{ env.ADMIN_IMAGE_NAME }} + image-tag: ${{ needs.prepare.outputs.image-tag }} + service-type: ${{ matrix.service-type }} + gcp-provider-id: ${{ secrets.GCP_PROVIDER_ID }} + gcp-service-account-email: ${{ secrets.GCP_SERVICE_ACCOUNT_EMAIL }} + add-latest-tag: ${{ inputs.add-latest-tag }} + + deploy-services: + name: Deploy CAS Services + needs: [ prepare, build-images ] + runs-on: ubuntu-latest + + permissions: + contents: write + id-token: write + + env: + DOCKER_REGISTRY_NAME: us-central1-docker.pkg.dev + COMPUTE_IMAGE_NAME: us-central1-docker.pkg.dev/${{ secrets.GCP_PROJECT_ID }}/cas-services-cicd/cas-compute + ADMIN_IMAGE_NAME: us-central1-docker.pkg.dev/${{ secrets.GCP_PROJECT_ID }}/cas-services-cicd/cas-admin + + steps: + - uses: actions/checkout@v4 + + - id: deploy-admin + name: Deploy the CAS Admin Service + uses: ./.github/actions/docker-deploy + if: inputs.service-type == 'admin' || inputs.service-type == 'both' + with: + docker-registry-name: ${{ env.DOCKER_REGISTRY_NAME }} + image-name: ${{ env.ADMIN_IMAGE_NAME }} + image-tag: ${{ needs.prepare.outputs.image-tag }} + gcp-provider-id: ${{ secrets.GCP_PROVIDER_ID }} + gcp-service-account-email: ${{ secrets.GCP_SERVICE_ACCOUNT_EMAIL }} + deployment-type: cas-admin + deployment-prefix: ${{ inputs.deployment-prefix }} + deployment-project: ${{ secrets.GCP_PROJECT_ID }} + deployment-service-account-email: ${{ inputs.service-account-email }} + deployment-sql-instance: ${{ inputs.sql-instance }} + deployment-vpc-connector: ${{ inputs.vpc-connector }} + deployment-config-secret: ${{ inputs.config-secret }} + deployment-region: ${{ inputs.region }} + deployment-flavor: ${{ inputs.flavor }} + + - id: deploy-compute + name: Deploy the CAS Compute Service + uses: ./.github/actions/docker-deploy + if: inputs.service-type == 'compute' || inputs.service-type == 'both' + with: + docker-registry-name: ${{ env.DOCKER_REGISTRY_NAME }} + image-name: ${{ env.COMPUTE_IMAGE_NAME }} + image-tag: ${{ needs.prepare.outputs.image-tag }} + gcp-provider-id: ${{ secrets.GCP_PROVIDER_ID }} + gcp-service-account-email: ${{ secrets.GCP_SERVICE_ACCOUNT_EMAIL }} + deployment-type: cas-compute + deployment-prefix: ${{ inputs.deployment-prefix }} + deployment-project: ${{ secrets.GCP_PROJECT_ID }} + deployment-service-account-email: ${{ inputs.service-account-email }} + deployment-sql-instance: ${{ inputs.sql-instance }} + deployment-vpc-connector: ${{ inputs.vpc-connector }} + deployment-config-secret: ${{ inputs.config-secret }} + deployment-region: ${{ inputs.region }} + deployment-flavor: ${{ inputs.flavor }} diff --git a/.github/workflows/deploy-workflow.yml b/.github/workflows/deploy-workflow.yml index 818490e7..d780a50c 100644 --- a/.github/workflows/deploy-workflow.yml +++ b/.github/workflows/deploy-workflow.yml @@ -53,11 +53,13 @@ jobs: - id: get-image-tag name: Get tag + env: + IMAGE_TAG: ${{ inputs.image-tag }} run: | - if [[ "${{ inputs.image-tag }}" == "" ]]; then + if [[ "$IMAGE_TAG" == "" ]]; then echo "IMAGE_TAG=latest" >> $GITHUB_ENV else - echo "IMAGE_TAG=${{ inputs.image-tag }}" >> $GITHUB_ENV + echo "IMAGE_TAG=$IMAGE_TAG" >> $GITHUB_ENV fi shell: bash - id: deploy-admin diff --git a/CHANGELOG.rst b/CHANGELOG.rst index 17eee98e..1fc05618 100644 --- a/CHANGELOG.rst +++ b/CHANGELOG.rst @@ -7,6 +7,72 @@ The format is based on `Keep a Changelog ` and this project adheres to `Semantic Versioning `_. +1.8.4 - 2026-04-29 +------------------ + +Added +~~~~~ +- Added API endpoint for serving precomputed Cell Ontology (CL) resources (#214) +- Added ``OntologicalColumnInfo`` model and API response fields for ontology column metadata (#214) +- Added script to generate and upload CL ontology resources (#214) +- Added unified build-and-deploy GitHub Actions workflow for CAS services +- Increased Uvicorn worker count and Cloud Run concurrency settings + +Fixed +~~~~~ +- Fixed VPC egress setting to ``private-ranges-only`` in deploy action +- Fixed image tag handling in build and deploy workflows + +Changed +~~~~~~~ +- Raised the minimum supported client version to ``1.8.0`` +- Updated dependencies: unpinned ``numpy`` (now resolved transitively), bumped ``torch`` lower bound to ``>=2.4.0`` +- Temporarily downgraded ``torch`` and ``cellarium-ml`` for compatibility, then re-pinned to stable versions + + +1.8.3 - 2026-04-15 +------------------ + +Added +~~~~~ +- Added ``memory_budget`` configuration option for the TileDB vector index + +Fixed +~~~~~ +- Fixed incorrect batch key handling in model inference (#212, #213) + +Changed +~~~~~~~ +- Updated Cloud Run deployment configuration + + +1.8.2 - 2026-04-07 +------------------ + +Added +~~~~~ +- Added TileDB Vector Search integration as the vector search backend (#209) +- Added support for querying cell metadata directly from the SOMA table +- Added support for multiple ontologies in cell annotation requests (#211) + +Removed +~~~~~~~ +- Removed Vertex AI Matching Engine client and all related vector search code (#209) + +Changed +~~~~~~~ +- Updated minimum required client version to 1.7.5 +- Refactored vector search layer with a factory pattern and type aliases + + +1.8.1 - 2026-03-20 +------------------ + +Fixed +~~~~~ +- Fixed Read the Docs configuration for Python 3.12 (#207) + + 1.8.0 - 2026-03-20 ------------------ diff --git a/Makefile b/Makefile index f4b1721a..586979c6 100644 --- a/Makefile +++ b/Makefile @@ -16,11 +16,7 @@ help: # Export requirements.txt.lock for production (Docker, etc.) requirements: - poetry export -f requirements.txt --output deploy/requirements.txt.lock --without-hashes --without dev,test,docs - -# Export requirements.txt.lock for Docker builds -docker-requirements: - poetry export -f requirements.txt --output deploy/requirements.txt.lock --without-hashes --without dev,docs + poetry export -f requirements.txt --output deploy/requirements.txt.lock --without-hashes --without dev,test,docs,scripts # Install Poetry setup: diff --git a/cellarium/cas_backend/apps/compute/routers/cellarium_general_router.py b/cellarium/cas_backend/apps/compute/routers/cellarium_general_router.py index b6638cfd..759822b1 100644 --- a/cellarium/cas_backend/apps/compute/routers/cellarium_general_router.py +++ b/cellarium/cas_backend/apps/compute/routers/cellarium_general_router.py @@ -1,7 +1,7 @@ import typing as t from fastapi import APIRouter, Depends -from fastapi.responses import RedirectResponse +from fastapi.responses import JSONResponse, RedirectResponse from cellarium.cas_backend.apps.compute import dependencies, schemas from cellarium.cas_backend.apps.compute.services.cell_quota_service import CellQuotaService @@ -147,3 +147,26 @@ async def increase_quota_for_user_by_email( """ user_for_increase = cellarium_general_service.get_user_by_email(user_email=user_email) cell_quota_service.increase_quota(admin_user=admin_user, user_for_increase=user_for_increase) + + +@cellarium_general_router.get("/cell-ontology-resource/{name}", response_model=schemas.CellOntologyResourceResponse) +async def get_cell_ontology_resource( + name: str, + _: AuthUser, + cellarium_general_service: GeneralService, +): + """ + Get a precomputed cell ontology resource by its unique name. + + Returns precomputed graph-derived fields so the client can skip building the ontology graph locally. + + :param name: Unique name of the ontological column resource + + :return: Precomputed cell ontology resource with cl_names, term-to-type mapping, + children dictionary, shortest and longest path lengths from root + """ + result = cellarium_general_service.get_cell_ontology_resource(name=name) + return JSONResponse( + content=result.model_dump(), + headers={"Cache-Control": "public, max-age=86400"}, + ) diff --git a/cellarium/cas_backend/apps/compute/schemas/__init__.py b/cellarium/cas_backend/apps/compute/schemas/__init__.py index 52e356e9..f775e470 100644 --- a/cellarium/cas_backend/apps/compute/schemas/__init__.py +++ b/cellarium/cas_backend/apps/compute/schemas/__init__.py @@ -16,6 +16,7 @@ from cellarium.cas_backend.apps.compute.schemas.cellarium_general import ( # noqa ApplicationInfo, CASModel, + CellOntologyResourceResponse, ClientVersionInput, ClientVersionOutput, FeatureSchemaInfo, diff --git a/cellarium/cas_backend/apps/compute/schemas/cellarium_general.py b/cellarium/cas_backend/apps/compute/schemas/cellarium_general.py index d8d5cea5..37231feb 100644 --- a/cellarium/cas_backend/apps/compute/schemas/cellarium_general.py +++ b/cellarium/cas_backend/apps/compute/schemas/cellarium_general.py @@ -1,6 +1,14 @@ import datetime -from pydantic import BaseModel, ConfigDict, Field, field_validator +from pydantic import AliasPath, BaseModel, ConfigDict, Field, field_validator + + +class OntologicalColumnInfo(BaseModel): + model_config = ConfigDict(from_attributes=True) + + ontology_resource_name: str + column_name: str + description: str | None = None class CASModel(BaseModel): @@ -11,6 +19,10 @@ class CASModel(BaseModel): schema_name: str = Field(example="refdata-gex-mm10-2020-A") is_default_model: bool = Field(example=False) embedding_dimension: int = Field(example=512) + ontological_columns: list[OntologicalColumnInfo] = Field( + default_factory=list, + validation_alias=AliasPath("cell_info_metadata", "ontological_columns"), + ) # Set the default value for description if it is provided as None @field_validator("description", mode="before") @@ -51,3 +63,11 @@ class ClientVersionInput(BaseModel): class ClientVersionOutput(BaseModel): is_valid: bool min_version: str + + +class CellOntologyResourceResponse(BaseModel): + cl_names: list[str] + cell_ontology_term_id_to_cell_type: dict[str, str] + children_dictionary: dict[str, list[str]] + shortest_path_lengths_from_cell_root: dict[str, int] + longest_path_lengths_from_cell_root: dict[str, int] diff --git a/cellarium/cas_backend/apps/compute/services/cellarium_general_service.py b/cellarium/cas_backend/apps/compute/services/cellarium_general_service.py index 8e5f6579..b989ace6 100644 --- a/cellarium/cas_backend/apps/compute/services/cellarium_general_service.py +++ b/cellarium/cas_backend/apps/compute/services/cellarium_general_service.py @@ -2,6 +2,7 @@ from cellarium.cas_backend.apps.compute import schemas from cellarium.cas_backend.apps.compute.services import exceptions +from cellarium.cas_backend.apps.compute.services.consensus_engine.strategies.ontology_aware import CellOntologyResource from cellarium.cas_backend.core import constants from cellarium.cas_backend.core.data_managers import CellariumGeneralDataManager from cellarium.cas_backend.core.db import models @@ -82,3 +83,21 @@ def get_user_by_email(self, user_email: str) -> models.User: :return: User object """ return self.cellarium_general_dm.get_user_by_email(user_email=user_email) + + def get_cell_ontology_resource(self, name: str) -> schemas.CellOntologyResourceResponse: + """ + Load and return a precomputed cell ontology resource by its unique name. + + :param name: Unique name of the ontological column + + :return: Precomputed cell ontology resource response + """ + column = self.cellarium_general_dm.get_ontological_column_by_name(ontology_resource_name=name) + resource = CellOntologyResource(ontology_resource_uri=column.ontology_resource_uri) + return schemas.CellOntologyResourceResponse( + cl_names=resource.cl_names, + cell_ontology_term_id_to_cell_type=resource.ontology_term_id_to_name_dict, + children_dictionary=resource.children_dictionary, + shortest_path_lengths_from_cell_root=resource.shortest_path_lengths_from_cell_root, + longest_path_lengths_from_cell_root=resource.longest_path_lengths_from_cell_root, + ) diff --git a/cellarium/cas_backend/apps/compute/services/consensus_engine/strategies/ontology_aware.py b/cellarium/cas_backend/apps/compute/services/consensus_engine/strategies/ontology_aware.py index 534bbfbe..200aea82 100644 --- a/cellarium/cas_backend/apps/compute/services/consensus_engine/strategies/ontology_aware.py +++ b/cellarium/cas_backend/apps/compute/services/consensus_engine/strategies/ontology_aware.py @@ -45,6 +45,17 @@ def __init__( self.ancestors_dictionary = cell_ontology_resource_dict["ancestors_dictionary"] self.ontology_term_id_to_name_dict = cell_ontology_resource_dict["cell_ontology_term_id_to_cell_type"] + self.children_dictionary: dict[str, list[str]] | None = cell_ontology_resource_dict.get("children_dictionary") + self.shortest_path_lengths_from_cell_root: dict[str, int] | None = cell_ontology_resource_dict.get( + "shortest_path_lengths_from_cell_root" + ) + self.longest_path_lengths_from_cell_root: dict[str, int] | None = cell_ontology_resource_dict.get( + "longest_path_lengths_from_cell_root" + ) + + @property + def cl_names(self) -> list[str]: + return sorted(self.ontology_term_id_to_name_dict.keys()) class CellTypeOntologyAwareConsensusStrategy(ConsensusStrategyInterface): @@ -116,8 +127,7 @@ def _calculate_cell_type_ontology_aware_scores( scores_dict = dict.fromkeys(self.cell_ontology_resource.ancestors_dictionary.keys(), 0) for neighbor_metadata, weight in zip(neighbor_metadata, weights, strict=False): - # Cell Ontology IDs have the formats: CL:0000000 (in our database) and CL_0000000 (in the ontology graph) - neighbor_cell_type_ontology_id = neighbor_metadata.cell_type_ontology_term_id.replace(":", "_") + neighbor_cell_type_ontology_id = neighbor_metadata.cell_type_ontology_term_id total_weight += weight total_neighbors += 1 diff --git a/cellarium/cas_backend/core/config.py b/cellarium/cas_backend/core/config.py index ed90d65f..7a03408b 100644 --- a/cellarium/cas_backend/core/config.py +++ b/cellarium/cas_backend/core/config.py @@ -23,7 +23,7 @@ class AllEnvSettings(BaseSettings): # General GOOGLE_ACCOUNT_CREDENTIALS: dict = json.loads(os.environ.get("GOOGLE_SERVICE_ACCOUNT_CREDENTIALS", "{}")) ENVIRONMENT: str = ENV_TYPE - APP_VERSION: str = "1.8.3" + APP_VERSION: str = "1.8.4" APP_ROOT: str = REPO_ROOT DEFAULT_FEATURE_SCHEMA: str = "refdata-gex-GRCh38-2020-A" PROJECT_BUCKET_NAME: str | None = os.environ.get("PROJECT_BUCKET_NAME") @@ -57,7 +57,7 @@ class AllEnvSettings(BaseSettings): API_REQUEST_TEMP_TABLE_DATASET_EXPIRATION: int = 10 # 10 minutes KNN_SEARCH_NUM_MATCHES_DEFAULT: int = 100 ITEMS_PER_USER: int = 50 - UVICORN_WORKERS: int = 1 + UVICORN_WORKERS: int = 2 MAX_CELL_IDS_PER_QUERY: int = 20_000 # Maximum number of cell IDs that can be queried at once # Consensus Engine # Auth diff --git a/cellarium/cas_backend/core/constants.py b/cellarium/cas_backend/core/constants.py index 5fc22ba1..083b5c68 100644 --- a/cellarium/cas_backend/core/constants.py +++ b/cellarium/cas_backend/core/constants.py @@ -1,7 +1,7 @@ from enum import Enum # The minimum client version that is allowed to connect to the server. -MIN_CLIENT_VERSION: str = "1.7.5" +MIN_CLIENT_VERSION: str = "1.8.0" class ContextKeys(str, Enum): diff --git a/cellarium/cas_backend/core/data_managers/cellarium_general.py b/cellarium/cas_backend/core/data_managers/cellarium_general.py index a3e11dbd..fe56c6bb 100644 --- a/cellarium/cas_backend/core/data_managers/cellarium_general.py +++ b/cellarium/cas_backend/core/data_managers/cellarium_general.py @@ -72,7 +72,15 @@ def get_models_all(self) -> list[models.CASModel]: :return: List of CAS models """ with self.system_data_db_session_maker() as session: - return session.query(models.CASModel).all() + return ( + session.query(models.CASModel) + .options( + orm.joinedload(models.CASModel.cell_info_metadata).joinedload( + models.CellInfoMetadata.ontological_columns + ) + ) + .all() + ) def get_models_non_admin(self) -> list[models.CASModel]: """ @@ -81,7 +89,16 @@ def get_models_non_admin(self) -> list[models.CASModel]: :return: List of CAS models """ with self.system_data_db_session_maker() as session: - return session.query(models.CASModel).filter_by(admin_use_only=False).all() + return ( + session.query(models.CASModel) + .options( + orm.joinedload(models.CASModel.cell_info_metadata).joinedload( + models.CellInfoMetadata.ontological_columns + ) + ) + .filter_by(admin_use_only=False) + .all() + ) def get_model_by_name(self, model_name: str) -> models.CASModel: """ @@ -149,3 +166,21 @@ def log_user_activity( with self.system_data_db_session_maker.begin() as session: session.add(user_activity) + + def get_ontological_column_by_name(self, ontology_resource_name: str) -> models.OntologicalColumn: + """ + Retrieve an ontological column by its unique ontology_resource_name. + + :param ontology_resource_name: Unique name of the ontological column + + :raises: NotFound if no ontological column with this name exists + + :return: OntologicalColumn object + """ + with self.system_data_db_session_maker() as session: + column = ( + session.query(models.OntologicalColumn).filter_by(ontology_resource_name=ontology_resource_name).first() + ) + if column is None: + raise exceptions.NotFound(f"Ontological column with name '{ontology_resource_name}' not found") + return column diff --git a/cellarium/cas_backend/core/db/migrations/versions/t_2026-04-15_16-08-00_add_name_to_ontological_column.py b/cellarium/cas_backend/core/db/migrations/versions/t_2026-04-15_16-08-00_add_name_to_ontological_column.py new file mode 100644 index 00000000..c3559974 --- /dev/null +++ b/cellarium/cas_backend/core/db/migrations/versions/t_2026-04-15_16-08-00_add_name_to_ontological_column.py @@ -0,0 +1,47 @@ +"""add_name_to_ontological_column + +Revision ID: c3d4e5f6a7b8 +Revises: b2c3d4e5f6a7 +Create Date: 2026-04-15 16:08:00.000000 + +""" + +import uuid + +from alembic import op +import sqlalchemy as sa + +# revision identifiers, used by Alembic. +revision = "6426fc752f63" +down_revision = "c3d4e5f6a7b8" +branch_labels = None +depends_on = None + + +def upgrade() -> None: + # 1. Add ontology_resource_name column as nullable first + op.add_column( + "ml_management_ontological_column", + sa.Column("ontology_resource_name", sa.String(length=255), nullable=True), + ) + + # 2. Populate existing rows with a generated unique name + connection = op.get_bind() + rows = connection.execute(sa.text("SELECT id, column_name FROM ml_management_ontological_column")).fetchall() + for row in rows: + generated_name = f"{row[1]}_{uuid.uuid4().hex[:8]}" + connection.execute( + sa.text("UPDATE ml_management_ontological_column SET ontology_resource_name = :name WHERE id = :id"), + {"name": generated_name, "id": row[0]}, + ) + + # 3. Make column non-nullable and add unique constraint + with op.batch_alter_table("ml_management_ontological_column") as batch_op: + batch_op.alter_column("ontology_resource_name", existing_type=sa.String(length=255), nullable=False) + batch_op.create_unique_constraint("uq_ontological_column_ontology_resource_name", ["ontology_resource_name"]) + + +def downgrade() -> None: + with op.batch_alter_table("ml_management_ontological_column") as batch_op: + batch_op.drop_constraint("uq_ontological_column_ontology_resource_name", type_="unique") + batch_op.drop_column("ontology_resource_name") diff --git a/cellarium/cas_backend/core/db/models/ml_management.py b/cellarium/cas_backend/core/db/models/ml_management.py index 3734c56b..5370a5eb 100644 --- a/cellarium/cas_backend/core/db/models/ml_management.py +++ b/cellarium/cas_backend/core/db/models/ml_management.py @@ -24,6 +24,7 @@ class OntologicalColumn(db.Base): cell_info_metadata = relationship( "CellInfoMetadata", backref=backref("ontological_columns", uselist=True, cascade="all, delete-orphan") ) + ontology_resource_name = sa.Column(sa.String(255), unique=True, nullable=False) column_name = sa.Column(sa.String(255), nullable=False) ontology_resource_uri = sa.Column(sa.String(1023), nullable=False) description = sa.Column(sa.Text, nullable=True) diff --git a/deploy/cloudrun/default.json b/deploy/cloudrun/default.json index 2c033713..75ccf07b 100644 --- a/deploy/cloudrun/default.json +++ b/deploy/cloudrun/default.json @@ -12,6 +12,6 @@ "memory": "32Gi", "max-instances": 200, "min-instances": 0, - "concurrency": 1 + "concurrency": 2 } } diff --git a/deploy/requirements.txt.lock b/deploy/requirements.txt.lock index e1416048..c4572a4f 100644 --- a/deploy/requirements.txt.lock +++ b/deploy/requirements.txt.lock @@ -1,4 +1,4 @@ ---extra-index-url https://download.pytorch.org/whl/cpu +--extra-index-url https://download-r2.pytorch.org/whl/cpu aiohttp==3.9.4 ; python_version >= "3.12" and python_version < "4.0" aiosignal==1.4.0 ; python_version >= "3.12" and python_version < "4.0" @@ -6,7 +6,7 @@ alembic==1.9.2 ; python_version >= "3.12" and python_version < "4.0" anndata==0.10.8 ; python_version >= "3.12" and python_version < "4.0" annotated-doc==0.0.4 ; python_version >= "3.12" and python_version < "4.0" annotated-types==0.7.0 ; python_version >= "3.12" and python_version < "4.0" -anyio==4.12.1 ; python_version >= "3.12" and python_version < "4.0" +anyio==4.13.0 ; python_version >= "3.12" and python_version < "4.0" argon2-cffi-bindings==25.1.0 ; python_version >= "3.12" and python_version < "4.0" argon2-cffi==23.1.0 ; python_version >= "3.12" and python_version < "4.0" array-api-compat==1.14.0 ; python_version >= "3.12" and python_version < "4.0" @@ -17,21 +17,22 @@ braceexpand==0.1.7 ; python_version >= "3.12" and python_version < "4.0" cellarium-ml==0.0.7 ; python_version >= "3.12" and python_version < "4.0" certifi==2026.2.25 ; python_version >= "3.12" and python_version < "4.0" cffi==2.0.0 ; python_version >= "3.12" and python_version < "4.0" -charset-normalizer==3.4.6 ; python_version >= "3.12" and python_version < "4.0" -click==8.3.1 ; python_version >= "3.12" and python_version < "4.0" +charset-normalizer==3.4.7 ; python_version >= "3.12" and python_version < "4.0" +click==8.3.2 ; python_version >= "3.12" and python_version < "4.0" cloud-sql-python-connector==1.11.0 ; python_version >= "3.12" and python_version < "4.0" colorama==0.4.6 ; python_version >= "3.12" and python_version < "4.0" and (platform_system == "Windows" or sys_platform == "win32") contourpy==1.3.3 ; python_version >= "3.12" and python_version < "4.0" crick==0.0.8 ; python_version >= "3.12" and python_version < "4.0" -cryptography==46.0.5 ; python_version >= "3.12" and python_version < "4.0" -cuda-bindings==12.9.4 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -cuda-pathfinder==1.4.3 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +cryptography==46.0.7 ; python_version >= "3.12" and python_version < "4.0" +cuda-bindings==13.2.0 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" +cuda-pathfinder==1.5.3 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" +cuda-toolkit==13.0.2 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" cycler==0.12.1 ; python_version >= "3.12" and python_version < "4.0" db-dtypes==1.1.1 ; python_version >= "3.12" and python_version < "4.0" decorator==5.2.1 ; python_version >= "3.12" and python_version < "4.0" -docstring-parser==0.17.0 ; python_version >= "3.12" and python_version < "4.0" +docstring-parser==0.18.0 ; python_version >= "3.12" and python_version < "4.0" fastapi==0.115.4 ; python_version >= "3.12" and python_version < "4.0" -filelock==3.25.2 ; python_version >= "3.12" and python_version < "4.0" +filelock==3.28.0 ; python_version >= "3.12" and python_version < "4.0" flask-admin==1.6.0 ; python_version >= "3.12" and python_version < "4.0" flask-httpauth==4.7.0 ; python_version >= "3.12" and python_version < "4.0" flask-wtf==1.2.2 ; python_version >= "3.12" and python_version < "4.0" @@ -41,35 +42,35 @@ frozenlist==1.8.0 ; python_version >= "3.12" and python_version < "4.0" fsspec==2023.9.2 ; python_version >= "3.12" and python_version < "4.0" gcsfs==2023.9.2 ; python_version >= "3.12" and python_version < "4.0" google-api-core==2.25.2 ; python_version >= "3.14" and python_version < "4.0" -google-api-core==2.30.0 ; python_version >= "3.12" and python_version < "3.14" +google-api-core==2.30.3 ; python_version >= "3.12" and python_version < "3.14" google-api-python-client==2.127.0 ; python_version >= "3.12" and python_version < "4.0" -google-auth-httplib2==0.3.0 ; python_version >= "3.12" and python_version < "4.0" -google-auth-oauthlib==1.3.0 ; python_version >= "3.12" and python_version < "4.0" -google-auth==2.49.1 ; python_version >= "3.12" and python_version < "4.0" +google-auth-httplib2==0.3.1 ; python_version >= "3.12" and python_version < "4.0" +google-auth-oauthlib==1.3.1 ; python_version >= "3.12" and python_version < "4.0" +google-auth==2.49.2 ; python_version >= "3.12" and python_version < "4.0" google-cloud-bigquery-storage==2.19.1 ; python_version >= "3.12" and python_version < "4.0" google-cloud-bigquery==3.9.0 ; python_version >= "3.12" and python_version < "4.0" -google-cloud-core==2.5.0 ; python_version >= "3.12" and python_version < "4.0" +google-cloud-core==2.5.1 ; python_version >= "3.12" and python_version < "4.0" google-cloud-run==0.7.1 ; python_version >= "3.12" and python_version < "4.0" google-cloud-storage==2.16.0 ; python_version >= "3.12" and python_version < "4.0" google-crc32c==1.8.0 ; python_version >= "3.12" and python_version < "4.0" -google-resumable-media==2.8.0 ; python_version >= "3.12" and python_version < "4.0" -googleapis-common-protos==1.73.0 ; python_version >= "3.12" and python_version < "4.0" -greenlet==3.3.2 ; python_version >= "3.12" and python_version < "4.0" and (platform_machine == "aarch64" or platform_machine == "ppc64le" or platform_machine == "x86_64" or platform_machine == "amd64" or platform_machine == "AMD64" or platform_machine == "win32" or platform_machine == "WIN32") -grpc-google-iam-v1==0.14.3 ; python_version >= "3.12" and python_version < "4.0" +google-resumable-media==2.8.2 ; python_version >= "3.12" and python_version < "4.0" +googleapis-common-protos==1.74.0 ; python_version >= "3.12" and python_version < "4.0" +greenlet==3.4.0 ; python_version >= "3.12" and python_version < "4.0" and (platform_machine == "aarch64" or platform_machine == "ppc64le" or platform_machine == "x86_64" or platform_machine == "amd64" or platform_machine == "AMD64" or platform_machine == "win32" or platform_machine == "WIN32") +grpc-google-iam-v1==0.14.4 ; python_version >= "3.12" and python_version < "4.0" grpcio-status==1.62.3 ; python_version >= "3.12" and python_version < "4.0" -grpcio==1.78.0 ; python_version >= "3.12" and python_version < "4.0" +grpcio==1.80.0 ; python_version >= "3.12" and python_version < "4.0" gunicorn==22.0.0 ; python_version >= "3.12" and python_version < "4.0" h11==0.16.0 ; python_version >= "3.12" and python_version < "4.0" h5py==3.16.0 ; python_version >= "3.12" and python_version < "4.0" -hf-xet==1.4.2 ; python_version >= "3.12" and python_version < "4.0" and (platform_machine == "x86_64" or platform_machine == "amd64" or platform_machine == "AMD64" or platform_machine == "arm64" or platform_machine == "aarch64") +hf-xet==1.4.3 ; python_version >= "3.12" and python_version < "4.0" and (platform_machine == "x86_64" or platform_machine == "amd64" or platform_machine == "AMD64" or platform_machine == "arm64" or platform_machine == "aarch64") httpcore==1.0.9 ; python_version >= "3.12" and python_version < "4.0" httplib2==0.31.2 ; python_version >= "3.12" and python_version < "4.0" httptools==0.7.1 ; python_version >= "3.12" and python_version < "4.0" httpx==0.28.1 ; python_version >= "3.12" and python_version < "4.0" -huggingface-hub==1.7.1 ; python_version >= "3.12" and python_version < "4.0" +huggingface-hub==1.11.0 ; python_version >= "3.12" and python_version < "4.0" idna==3.11 ; python_version >= "3.12" and python_version < "4.0" importlib-metadata==9.0.0 ; python_version >= "3.12" and python_version < "4.0" -importlib-resources==6.5.2 ; python_version >= "3.12" and python_version < "4.0" +importlib-resources==7.1.0 ; python_version >= "3.12" and python_version < "4.0" iniconfig==2.3.0 ; python_version >= "3.12" and python_version < "4.0" itsdangerous==2.2.0 ; python_version >= "3.12" and python_version < "4.0" jinja2==3.1.6 ; python_version >= "3.12" and python_version < "4.0" @@ -81,72 +82,69 @@ kiwisolver==1.5.0 ; python_version >= "3.12" and python_version < "4.0" legacy-api-wrap==1.5 ; python_version >= "3.12" and python_version < "4.0" lightning-utilities==0.15.3 ; python_version >= "3.12" and python_version < "4.0" lightning==2.3.0 ; python_version >= "3.12" and python_version < "4.0" -llvmlite==0.46.0 ; python_version >= "3.12" and python_version < "4.0" +llvmlite==0.47.0 ; python_version >= "3.12" and python_version < "4.0" mako==1.2.4 ; python_version >= "3.12" and python_version < "4.0" markdown-it-py==4.0.0 ; python_version >= "3.12" and python_version < "4.0" markupsafe==3.0.3 ; python_version >= "3.12" and python_version < "4.0" matplotlib==3.10.8 ; python_version >= "3.12" and python_version < "4.0" mdurl==0.1.2 ; python_version >= "3.12" and python_version < "4.0" -more-itertools==10.8.0 ; python_version >= "3.12" and python_version < "4.0" +more-itertools==11.0.2 ; python_version >= "3.12" and python_version < "4.0" mpmath==1.3.0 ; python_version >= "3.12" and python_version < "4.0" multidict==6.7.1 ; python_version >= "3.12" and python_version < "4.0" natsort==8.4.0 ; python_version >= "3.12" and python_version < "4.0" networkx==3.3 ; python_version >= "3.12" and python_version < "4.0" -numba==0.64.0 ; python_version >= "3.12" and python_version < "4.0" -numpy==1.26.4 ; python_version >= "3.12" and python_version < "4.0" +numba==0.65.0 ; python_version >= "3.12" and python_version < "4.0" +numpy==2.4.4 ; python_version >= "3.12" and python_version < "4.0" nvidia-cublas-cu12==12.1.3.1 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cublas-cu12==12.6.4.1 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cublas-cu12==12.8.4.1 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cublas==13.1.0.3 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" nvidia-cuda-cupti-cu12==12.1.105 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cuda-cupti-cu12==12.6.80 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cuda-cupti-cu12==12.8.90 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cuda-cupti==13.0.85 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" nvidia-cuda-nvrtc-cu12==12.1.105 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cuda-nvrtc-cu12==12.6.77 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cuda-nvrtc-cu12==12.8.93 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cuda-nvrtc==13.0.88 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" nvidia-cuda-runtime-cu12==12.1.105 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cuda-runtime-cu12==12.6.77 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cuda-runtime-cu12==12.8.90 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cudnn-cu12==8.9.2.26 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" -nvidia-cudnn-cu12==9.10.2.21 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cuda-runtime==13.0.96 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" +nvidia-cudnn-cu12==9.1.0.70 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cudnn-cu12==9.5.1.17 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cudnn-cu13==9.19.0.56 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" nvidia-cufft-cu12==11.0.2.54 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cufft-cu12==11.3.0.4 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cufft-cu12==11.3.3.83 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cufft==12.0.0.61 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" nvidia-cufile-cu12==1.11.1.6 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cufile-cu12==1.13.1.3 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" nvidia-curand-cu12==10.3.2.106 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-curand-cu12==10.3.7.77 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-curand-cu12==10.3.9.90 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-curand==10.4.0.35 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" nvidia-cusolver-cu12==11.4.5.107 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cusolver-cu12==11.7.1.2 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cusolver-cu12==11.7.3.90 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cusolver==12.0.4.66 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" nvidia-cusparse-cu12==12.1.0.106 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-cusparse-cu12==12.5.4.2 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cusparse-cu12==12.5.8.93 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-cusparse==12.6.3.3 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" nvidia-cusparselt-cu12==0.6.3 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-cusparselt-cu12==0.7.1 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-nccl-cu12==2.19.3 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" +nvidia-cusparselt-cu13==0.8.0 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" +nvidia-nccl-cu12==2.20.5 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-nccl-cu12==2.26.2 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-nccl-cu12==2.27.5 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-nvjitlink-cu12==12.6.85 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-nvjitlink-cu12==12.8.93 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-nvjitlink-cu12==12.9.86 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" -nvidia-nvshmem-cu12==3.4.5 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-nccl-cu13==2.28.9 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" +nvidia-nvjitlink-cu12==12.6.85 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and (sys_platform == "darwin" or python_version >= "3.14") and sys_platform != "linux" +nvidia-nvjitlink==13.0.88 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" +nvidia-nvshmem-cu13==3.4.5 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" nvidia-nvtx-cu12==12.1.105 ; python_version >= "3.12" and python_version < "4.0" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" nvidia-nvtx-cu12==12.6.77 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -nvidia-nvtx-cu12==12.8.90 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +nvidia-nvtx==13.0.85 ; python_version >= "3.12" and python_version < "3.14" and sys_platform == "win32" and platform_system == "Linux" oauthlib==3.3.1 ; python_version >= "3.12" and python_version < "4.0" opt-einsum==3.4.0 ; python_version >= "3.12" and python_version < "4.0" -owlready2==0.46 ; python_version >= "3.12" and python_version < "4.0" packaging==24.2 ; python_version >= "3.12" and python_version < "4.0" pandas==2.2.3 ; python_version >= "3.12" and python_version < "4.0" patsy==1.0.2 ; python_version >= "3.12" and python_version < "4.0" pg8000==1.31.2 ; python_version >= "3.12" and python_version < "4.0" -pillow==12.1.1 ; python_version >= "3.12" and python_version < "4.0" +pillow==12.2.0 ; python_version >= "3.12" and python_version < "4.0" pluggy==1.6.0 ; python_version >= "3.12" and python_version < "4.0" propcache==0.4.1 ; python_version >= "3.12" and python_version < "4.0" -proto-plus==1.27.1 ; python_version >= "3.12" and python_version < "4.0" -protobuf==4.25.8 ; python_version >= "3.12" and python_version < "4.0" +proto-plus==1.27.2 ; python_version >= "3.12" and python_version < "4.0" +protobuf==4.25.9 ; python_version >= "3.12" and python_version < "4.0" pyarrow-hotfix==0.7 ; python_version >= "3.12" and python_version < "4.0" pyarrow==18.1.0 ; python_version >= "3.12" and python_version < "4.0" pyasn1-modules==0.4.2 ; python_version >= "3.12" and python_version < "4.0" @@ -155,13 +153,13 @@ pycparser==3.0 ; python_version >= "3.12" and python_version < "4.0" and impleme pydantic-core==2.20.1 ; python_version >= "3.12" and python_version < "4.0" pydantic-settings==2.3.4 ; python_version >= "3.12" and python_version < "4.0" pydantic==2.8.2 ; python_version >= "3.12" and python_version < "4.0" -pygments==2.19.2 ; python_version >= "3.12" and python_version < "4.0" +pygments==2.20.0 ; python_version >= "3.12" and python_version < "4.0" pyjwt==2.6.0 ; python_version >= "3.12" and python_version < "4.0" pynndescent==0.6.0 ; python_version >= "3.12" and python_version < "4.0" pyparsing==3.3.2 ; python_version >= "3.12" and python_version < "4.0" pyro-api==0.1.2 ; python_version >= "3.12" and python_version < "4.0" pyro-ppl==1.9.1 ; python_version >= "3.12" and python_version < "4.0" -pytest==9.0.2 ; python_version >= "3.12" and python_version < "4.0" +pytest==9.0.3 ; python_version >= "3.12" and python_version < "4.0" python-dateutil==2.9.0.post0 ; python_version >= "3.12" and python_version < "4.0" python-dotenv==1.0.1 ; python_version >= "3.12" and python_version < "4.0" python-http-client==3.3.7 ; python_version >= "3.12" and python_version < "4.0" @@ -170,20 +168,20 @@ pytorch-lightning==2.6.1 ; python_version >= "3.12" and python_version < "4.0" pytz==2026.1.post1 ; python_version >= "3.12" and python_version < "4.0" pyyaml==6.0.3 ; python_version >= "3.12" and python_version < "4.0" referencing==0.37.0 ; python_version >= "3.12" and python_version < "4.0" -regex==2026.2.28 ; python_version >= "3.12" and python_version < "4.0" +regex==2026.4.4 ; python_version >= "3.12" and python_version < "4.0" requests-oauthlib==2.0.0 ; python_version >= "3.12" and python_version < "4.0" requests==2.31.0 ; python_version >= "3.12" and python_version < "4.0" -rich==14.3.3 ; python_version >= "3.12" and python_version < "4.0" +rich==15.0.0 ; python_version >= "3.12" and python_version < "4.0" rpds-py==0.30.0 ; python_version >= "3.12" and python_version < "4.0" safetensors==0.7.0 ; python_version >= "3.12" and python_version < "4.0" scanpy==1.11.5 ; python_version >= "3.12" and python_version < "4.0" -scikit-learn==1.4.2 ; python_version >= "3.12" and python_version < "4.0" -scipy==1.13.0 ; python_version >= "3.12" and python_version < "4.0" +scikit-learn==1.8.0 ; python_version >= "3.12" and python_version < "4.0" +scipy==1.17.1 ; python_version >= "3.12" and python_version < "4.0" scramp==1.4.8 ; python_version >= "3.12" and python_version < "4.0" seaborn==0.13.2 ; python_version >= "3.12" and python_version < "4.0" sendgrid==6.11.0 ; python_version >= "3.12" and python_version < "4.0" sentry-sdk==1.39.2 ; python_version >= "3.12" and python_version < "4.0" -session-info2==0.4 ; python_version >= "3.12" and python_version < "4.0" +session-info2==0.4.1 ; python_version >= "3.12" and python_version < "4.0" setuptools==81.0.0 ; python_version >= "3.12" and python_version < "4.0" shapely==2.1.2 ; python_version >= "3.12" and python_version < "4.0" shellingham==1.5.4 ; python_version >= "3.12" and python_version < "4.0" @@ -200,27 +198,28 @@ sympy==1.14.0 ; python_version >= "3.12" and python_version < "4.0" tblib==3.2.2 ; python_version >= "3.12" and python_version < "4.0" tenacity==8.2.3 ; python_version >= "3.12" and python_version < "4.0" threadpoolctl==3.6.0 ; python_version >= "3.12" and python_version < "4.0" -tiledb-cloud==0.14.3 ; python_version >= "3.12" and python_version < "4.0" +tiledb-cloud==0.14.4 ; python_version >= "3.12" and python_version < "4.0" tiledb-vector-search==0.16.0 ; python_version >= "3.12" and python_version < "4.0" tiledb==0.36.1 ; python_version >= "3.12" and python_version < "4.0" tiledbsoma==2.3.0 ; python_version >= "3.12" and python_version < "4.0" tokenizers==0.22.2 ; python_version >= "3.12" and python_version < "4.0" -torch==2.10.0 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" -torch==2.2.2 ; python_version >= "3.12" and python_version < "4.0" and sys_platform == "darwin" -torch==2.2.2+cpu ; python_version >= "3.12" and python_version < "4.0" and sys_platform == "linux" +torch==2.11.0 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" +torch==2.4.1 ; python_version >= "3.12" and python_version < "4.0" and sys_platform == "darwin" +torch==2.4.1+cpu ; python_version >= "3.12" and python_version < "4.0" and sys_platform == "linux" torch==2.7.1 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" torchmetrics==1.9.0 ; python_version >= "3.12" and python_version < "4.0" tqdm==4.67.3 ; python_version >= "3.12" and python_version < "4.0" -transformers==5.3.0 ; python_version >= "3.12" and python_version < "4.0" +transformers==5.5.4 ; python_version >= "3.12" and python_version < "4.0" +triton==3.0.0 ; python_version == "3.12" and platform_system == "Linux" and platform_machine == "x86_64" and sys_platform == "darwin" triton==3.3.1 ; python_version >= "3.14" and python_version < "4.0" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" -triton==3.6.0 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" and platform_machine == "x86_64" +triton==3.6.0 ; python_version >= "3.12" and python_version < "3.14" and sys_platform != "darwin" and sys_platform != "linux" and platform_system == "Linux" typer==0.24.1 ; python_version >= "3.12" and python_version < "4.0" typeshed-client==2.9.0 ; python_version >= "3.12" and python_version < "4.0" typing-extensions==4.15.0 ; python_version >= "3.12" and python_version < "4.0" -tzdata==2025.3 ; python_version >= "3.12" and python_version < "4.0" -umap-learn==0.5.7 ; python_version >= "3.12" and python_version < "4.0" +tzdata==2026.1 ; python_version >= "3.12" and python_version < "4.0" +umap-learn==0.5.12 ; python_version >= "3.12" and python_version < "4.0" uritemplate==4.2.0 ; python_version >= "3.12" and python_version < "4.0" -urllib3==2.6.3 ; python_version >= "3.12" and python_version < "4.0" +urllib3==2.5.0 ; python_version >= "3.12" and python_version < "4.0" uvicorn==0.29.0 ; python_version >= "3.12" and python_version < "4.0" uvloop==0.22.1 ; python_version >= "3.12" and python_version < "4.0" and platform_python_implementation != "PyPy" and sys_platform != "win32" and sys_platform != "cygwin" watchfiles==1.1.1 ; python_version >= "3.12" and python_version < "4.0" @@ -229,4 +228,4 @@ werkzeug==3.0.6 ; python_version >= "3.12" and python_version < "4.0" wrapt==2.1.2 ; python_version >= "3.12" and python_version < "4.0" wtforms==3.1.2 ; python_version >= "3.12" and python_version < "4.0" yarl==1.23.0 ; python_version >= "3.12" and python_version < "4.0" -zipp==3.23.0 ; python_version >= "3.12" and python_version < "4.0" +zipp==3.23.1 ; python_version >= "3.12" and python_version < "4.0" diff --git a/docs/source/index.rst b/docs/source/index.rst index d9a4e550..76bd467a 100644 --- a/docs/source/index.rst +++ b/docs/source/index.rst @@ -20,6 +20,7 @@ Operations Guides .. toctree:: :maxdepth: 1 + modules/scripts modules/running_locally modules/deploying_in_cloud modules/cicd diff --git a/docs/source/modules/scripts.rst b/docs/source/modules/scripts.rst new file mode 100644 index 00000000..be7813e1 --- /dev/null +++ b/docs/source/modules/scripts.rst @@ -0,0 +1 @@ +.. include:: ../../../scripts/README.rst diff --git a/poetry.lock b/poetry.lock index 4d3e7f01..25cd9703 100644 --- a/poetry.lock +++ b/poetry.lock @@ -196,14 +196,14 @@ files = [ [[package]] name = "anyio" -version = "4.12.1" +version = "4.13.0" description = "High-level concurrency and networking framework on top of asyncio or Trio" optional = false -python-versions = ">=3.9" +python-versions = ">=3.10" groups = ["main"] files = [ - {file = "anyio-4.12.1-py3-none-any.whl", hash = "sha256:d405828884fc140aa80a3c667b8beed277f1dfedec42ba031bd6ac3db606ab6c"}, - {file = "anyio-4.12.1.tar.gz", hash = "sha256:41cfcc3a4c85d3f05c932da7c26d0201ac36f72abd4435ba90d0464a3ffed703"}, + {file = "anyio-4.13.0-py3-none-any.whl", hash = "sha256:08b310f9e24a9594186fd75b4f73f4a4152069e3853f1ed8bfbf58369f4ad708"}, + {file = "anyio-4.13.0.tar.gz", hash = "sha256:334b70e641fd2221c1505b3890c69882fe4a2df910cba14d97019b90b24439dc"}, ] [package.dependencies] @@ -211,7 +211,7 @@ idna = ">=2.8" typing_extensions = {version = ">=4.5", markers = "python_version < \"3.13\""} [package.extras] -trio = ["trio (>=0.31.0) ; python_version < \"3.10\"", "trio (>=0.32.0) ; python_version >= \"3.10\""] +trio = ["trio (>=0.32.0)"] [[package]] name = "argon2-cffi" @@ -557,153 +557,153 @@ pycparser = {version = "*", markers = "implementation_name != \"PyPy\""} [[package]] name = "charset-normalizer" -version = "3.4.6" +version = "3.4.7" description = "The Real First Universal Charset Detector. 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python-versions = "^3.12" -content-hash = "8b2a48a9822d65b0118a127a4f421636d00db069358b479537ee85e5db457d11" +content-hash = "7153b78b45159e0b163370c7af5284cb30b856a58f310b25f7916c5128e9b0df" diff --git a/pyproject.toml b/pyproject.toml index 81d7521c..e955e4b2 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -47,8 +47,8 @@ gcsfs = "2023.9.2" tenacity = "8.2.3" lightning= ">=2.2.0,<=2.3.0" torch = [ - { version = ">=2.2.0,<2.7.0", markers = "sys_platform == 'darwin'" }, - { version = ">=2.2.0,<2.7.0", markers = "sys_platform == 'linux'", source = "pytorch-cpu" } + { version = ">=2.2.0,<2.5.0", markers = "sys_platform == 'darwin'"}, + { version = ">=2.2.0,<2.5.0", markers = "sys_platform == 'linux'", source = "pytorch-cpu" } ] starlette = "0.41.2" starlette-context = "0.3.6" @@ -57,13 +57,18 @@ sendgrid = "6.11.0" packaging = "24.2" pydantic = "2.8.2" pydantic-settings = "2.3.4" -numpy = "1.26.4" -owlready2 = "0.46" -networkx = "3.3" setuptools = "<82" tiledb-vector-search = "0.16.0" tiledbsoma = ">=2.3.0,<2.4.0" +[tool.poetry.group.scripts] +optional = true + +[tool.poetry.group.scripts.dependencies] +owlready2 = "0.46" +networkx = "3.3" +click = ">=8.0.0" + [tool.poetry.group.dev.dependencies] wheel = "*" ruff = "^0.8.0" @@ -100,7 +105,8 @@ pillow = "^12.1.1" [[tool.poetry.source]] name = "pytorch-cpu" -url = "https://download.pytorch.org/whl/cpu" +#url = "https://download.pytorch.org/whl/cpu" +url = "https://download-r2.pytorch.org/whl/cpu" priority = "explicit" [build-system] diff --git a/scripts/README.rst b/scripts/README.rst new file mode 100644 index 00000000..f156b4ce --- /dev/null +++ b/scripts/README.rst @@ -0,0 +1,48 @@ +Scripts +======= + +Standalone utility scripts for one-off data preparation tasks. These are **not** part of the deployed +application and require the optional ``scripts`` dependency group:: + + poetry install --with scripts + +create_cell_ontology_resource.py +-------------------------------- + +Generates the Cell Type Ontology resource JSON consumed by the CAS API from a CL OWL file. + +The output JSON contains five precomputed fields: + +- ``ancestors_dictionary`` — maps each CL term to its ordered list of ancestors +- ``cell_ontology_term_id_to_cell_type`` — maps each CL term to its human-readable label +- ``children_dictionary`` — maps each CL term to its direct children +- ``shortest_path_lengths_from_cell_root`` — BFS distance from ``CL:0000000`` to each term +- ``longest_path_lengths_from_cell_root`` — longest DAG path from ``CL:0000000`` to each term + +Usage +~~~~~ + +.. code-block:: shell + + python scripts/create_cell_ontology_resource.py \ + --owl-url https://github.com/obophenotype/cell-ontology/releases/download/v2025-07-30/cl.owl \ + --output gs://your-bucket/path/to/cell_ontology_resource.json + +Arguments +~~~~~~~~~ + +.. option:: --owl-url + + URL or local filesystem path to the CL OWL file. Accepts any URL supported by ``owlready2``. + +.. option:: --output + + Destination file path for the resulting JSON. Accepts local paths or GCS URIs + (``gs://bucket/path/resource.json``) via ``smart-open``. + +Output +~~~~~~ + +The script writes a single JSON file. The resource must then be uploaded to the +``OntologicalColumn`` record in the database (via the Admin interface) and the GCS path stored +in ``OntologicalColumn.ontology_resource_name`` so the API can look it up by name. diff --git a/scripts/create_cell_ontology_resource.py b/scripts/create_cell_ontology_resource.py new file mode 100644 index 00000000..8663bdc5 --- /dev/null +++ b/scripts/create_cell_ontology_resource.py @@ -0,0 +1,187 @@ +""" +Create the Cell Type Ontology resource JSON used by the Cellarium CAS backend. + +The output JSON contains five precomputed fields consumed by the API: + + - ancestors_dictionary + - cell_ontology_term_id_to_cell_type + - children_dictionary + - shortest_path_lengths_from_cell_root + - longest_path_lengths_from_cell_root + +Example:: + + python scripts/create_cell_ontology_resource.py \\ + --owl-url https://github.com/obophenotype/cell-ontology/releases/download/v2025-07-30/cl.owl \\ + --output gs://your-bucket/path/to/cell_ontology_resource.json +""" + +import json +import logging +import typing as t + +import click +import networkx as nx +import owlready2 +from smart_open import open + +CELL_ROOT = "CL:0000000" +_OWL_NAME_PREFIX = "CL_" + +logging.basicConfig(level=logging.INFO) + + +def _owl_name_to_cl_id(owl_name: str) -> str: + """Convert owlready2 internal name (CL_XXXXXXX) to standard CL ID (CL:XXXXXXX).""" + return owl_name.replace("CL_", "CL:", 1) + + +def build_nx_graph_from_cl_ontology( + cl_ontology: owlready2.Ontology, cl_classes: t.List[owlready2.EntityClass] +) -> nx.DiGraph: + """ + Build a directed graph from a CL ontology. Edges go from parent to child. + Node names use standard CL: ID format. + """ + logging.info("Building nx graph from cl ontology...") + cl_graph = nx.DiGraph(name="CL graph") + cl_classes_set = set(cl_classes) + + for cl_class in cl_classes: + cl_graph.add_node(_owl_name_to_cl_id(cl_class.name)) + + for cl_class in cl_classes: + cl_id = _owl_name_to_cl_id(cl_class.name) + for parent_cl_class in cl_ontology.get_parents_of(entity=cl_class): + if parent_cl_class in cl_classes_set: + cl_graph.add_edge(_owl_name_to_cl_id(parent_cl_class.name), cl_id) + for child_cl_class in cl_ontology.get_children_of(Class=cl_class): + if child_cl_class in cl_classes_set: + cl_graph.add_edge(cl_id, _owl_name_to_cl_id(child_cl_class.name)) + + return cl_graph + + +def build_ancestors_dictionary( + cl_graph: nx.DiGraph, cl_names: t.List[str], cl_names_to_idx_map: t.Dict[str, int] +) -> t.Dict[str, t.List[str]]: + """ + Build ancestor dictionary mapping each CL term to an ordered list of all its ancestors. + Ordering follows the original index ordering of cl_names. + """ + logging.info("Building cell ontology ancestor dictionary...") + ancestors_dictionary = {} + + for cl_name in cl_names: + current_ancestors = list(sorted(nx.ancestors(cl_graph, cl_name))) + ancestors_dictionary[cl_name] = [ + a for _, a in sorted(zip([cl_names_to_idx_map[a] for a in current_ancestors], current_ancestors)) + ] + + return ancestors_dictionary + + +def build_children_dictionary(cl_graph: nx.DiGraph, cl_names: t.List[str]) -> t.Dict[str, t.List[str]]: + """ + Build children dictionary mapping each CL term to its direct (non-transitive) children. + """ + logging.info("Building cell ontology children dictionary...") + return {cl_name: sorted(cl_graph.successors(cl_name)) for cl_name in cl_names} + + +def compute_shortest_path_lengths_from_root(cl_graph: nx.DiGraph) -> t.Dict[str, int]: + """ + Compute the shortest path length from CL:0000000 to every reachable descendant. Root = 0. + """ + logging.info("Computing shortest path lengths from root...") + return dict(nx.single_source_shortest_path_length(cl_graph, CELL_ROOT)) + + +def compute_longest_path_lengths_from_root(cl_graph: nx.DiGraph) -> t.Dict[str, int]: + """ + Compute the longest path length from CL:0000000 to every reachable descendant using + topological-order dynamic programming. Root = 0. Unreachable nodes are excluded. + """ + logging.info("Computing longest path lengths from root...") + dist: t.Dict[str, int] = {} + + for node in nx.topological_sort(cl_graph): + if node == CELL_ROOT: + dist[node] = 0 + if node not in dist: + continue + for child in cl_graph.successors(node): + if child not in dist or dist[child] < dist[node] + 1: + dist[child] = dist[node] + 1 + + return dist + + +@click.command() +@click.option( + "--owl-url", + required=True, + help="URL or local path to the CL OWL file.", +) +@click.option( + "--output", + required=True, + help="Output file path (local or GCS, e.g. gs://bucket/path/resource.json).", +) +def main(owl_url: str, output: str) -> None: + """Create the Cell Type Ontology resource JSON for Cellarium CAS.""" + logging.info("Generating cell type ontology resource from CL ontology...") + + # cl.owl imports ontologies (e.g. STATO) that define entities as both a property and + # a class, which owlready2 rejects in _load_properties. Those entities are outside the + # CL namespace and do not affect output, so we silence the specific TypeError. + _orig = owlready2.Ontology._load_properties + + def _safe_load_properties(self: owlready2.Ontology) -> None: + try: + _orig(self) + except TypeError as exc: + logging.warning("Skipping property-loading error (imported ontology): %s", exc) + + owlready2.Ontology._load_properties = _safe_load_properties + try: + cl_ontology = owlready2.get_ontology(owl_url).load() + finally: + owlready2.Ontology._load_properties = _orig + + cl_classes = [ + _class + for _class in cl_ontology.classes() + if _class.name.startswith(_OWL_NAME_PREFIX) and len(_class.label) == 1 + ] + + # Build id->label mapping directly from class objects to avoid set-ordering bugs + seen: t.Dict[str, str] = {} + for _class in cl_classes: + cl_id = _owl_name_to_cl_id(_class.name) + if cl_id not in seen: + seen[cl_id] = _class.label[0] + + cl_names_to_labels_map = seen + cl_names = sorted(cl_names_to_labels_map.keys()) + cl_names_to_idx_map = {cl_name: idx for idx, cl_name in enumerate(cl_names)} + + cl_graph = build_nx_graph_from_cl_ontology(cl_ontology=cl_ontology, cl_classes=cl_classes) + + cell_ontology_resource = { + "ancestors_dictionary": build_ancestors_dictionary( + cl_graph=cl_graph, cl_names=cl_names, cl_names_to_idx_map=cl_names_to_idx_map + ), + "cell_ontology_term_id_to_cell_type": cl_names_to_labels_map, + "children_dictionary": build_children_dictionary(cl_graph=cl_graph, cl_names=cl_names), + "shortest_path_lengths_from_cell_root": compute_shortest_path_lengths_from_root(cl_graph=cl_graph), + "longest_path_lengths_from_cell_root": compute_longest_path_lengths_from_root(cl_graph=cl_graph), + } + + logging.info(f"Writing output file to {output}") + with open(output, "w") as output_file: + json.dump(cell_ontology_resource, output_file) + + +if __name__ == "__main__": + main() diff --git a/tests/unit/fixtures/constants.py b/tests/unit/fixtures/constants.py index a82ce989..b93c96f6 100644 --- a/tests/unit/fixtures/constants.py +++ b/tests/unit/fixtures/constants.py @@ -9,6 +9,7 @@ TEST_MODEL_CELL_METADATA_URI = "gs://unknown" TEST_CELL_INFO_METADATA_NAME = "test-cell-info-metadata" TEST_CELL_TYPE_ONTOLOGY_RESOURCE_URI = "gs://unknown/cell_ontology_resource.json" +TEST_ONTOLOGICAL_COLUMN_NAME = "cell-type-ontology-v1" TEST_MODEL_ADMIN_USE_ONLY = False TEST_EMBEDDING_DIMENSION = 32 TEST_INDEX_NAME = "test-index-name" diff --git a/tests/unit/fixtures/database.py b/tests/unit/fixtures/database.py index f4da4745..dce45370 100644 --- a/tests/unit/fixtures/database.py +++ b/tests/unit/fixtures/database.py @@ -111,6 +111,7 @@ def populate_db( ontological_column = models.OntologicalColumn( id=1, cell_info_metadata=cell_info_metadata, + ontology_resource_name=constants.TEST_ONTOLOGICAL_COLUMN_NAME, column_name="cell_type", ontology_resource_uri=constants.TEST_CELL_TYPE_ONTOLOGY_RESOURCE_URI, ) diff --git a/tests/unit/scripts/__init__.py b/tests/unit/scripts/__init__.py new file mode 100644 index 00000000..e69de29b diff --git a/tests/unit/scripts/test_create_cell_ontology_resource_script.py b/tests/unit/scripts/test_create_cell_ontology_resource_script.py new file mode 100644 index 00000000..285986bd --- /dev/null +++ b/tests/unit/scripts/test_create_cell_ontology_resource_script.py @@ -0,0 +1,406 @@ +""" +Unit tests for scripts/create_cell_ontology_resource.py. + +These tests exercise every function in the script using a small hand-crafted +networkx graph so that owlready2 and a real OWL file are not required. +""" + +import json +from pathlib import Path +import tempfile +from unittest.mock import MagicMock, patch + +from click.testing import CliRunner +import networkx as nx +import pytest + +from scripts.create_cell_ontology_resource import ( + CELL_ROOT, + _owl_name_to_cl_id, + build_ancestors_dictionary, + build_children_dictionary, + build_nx_graph_from_cl_ontology, + compute_longest_path_lengths_from_root, + compute_shortest_path_lengths_from_root, + main, +) + + +def _make_simple_graph() -> nx.DiGraph: + """ + Simple 4-node DAG: + CL:0000000 → CL:0000001 → CL:0000002 + ↘ ↗ + CL:0000003 + CL:0000002 is reachable from root via two paths of lengths 2 and 2, + but the longest is 2 via CL:0000003 too — both paths len 2. + """ + g = nx.DiGraph() + g.add_edges_from( + [ + ("CL:0000000", "CL:0000001"), + ("CL:0000001", "CL:0000002"), + ("CL:0000000", "CL:0000003"), + ("CL:0000003", "CL:0000002"), + ] + ) + return g + + +def _make_deep_graph() -> nx.DiGraph: + """Linear chain: root → A → B → C""" + g = nx.DiGraph() + g.add_edges_from( + [ + (CELL_ROOT, "CL:0000001"), + ("CL:0000001", "CL:0000002"), + ("CL:0000002", "CL:0000003"), + ] + ) + return g + + +def test_owl_name_to_cl_id_replaces_prefix(): + """Standard CL_ prefix is converted to CL:.""" + assert _owl_name_to_cl_id("CL_0000001") == "CL:0000001" + + +def test_owl_name_to_cl_id_only_replaces_first_occurrence(): + """Only the leading CL_ prefix is replaced; subsequent occurrences are left intact.""" + assert _owl_name_to_cl_id("CL_CL_0000001") == "CL:CL_0000001" + + +def test_owl_name_to_cl_id_non_cl_name_unchanged(): + """Non-CL ontology names are returned without modification.""" + assert _owl_name_to_cl_id("GO_0008150") == "GO_0008150" + + +def _make_mock_class(name: str, label: str, parents=None, children=None): + cls = MagicMock() + cls.name = name + cls.label = [label] + cls.__hash__ = lambda self: hash(name) + cls.__eq__ = lambda self, other: self.name == getattr(other, "name", None) + return cls + + +def test_build_nx_graph_nodes_use_cl_colon_format(): + """Graph nodes must use CL: format, not the owlready2 internal CL_ format.""" + a = _make_mock_class("CL_0000000", "cell") + b = _make_mock_class("CL_0000001", "somatic cell") + + ontology = MagicMock() + ontology.get_parents_of.side_effect = lambda entity: [a] if entity is b else [] + ontology.get_children_of.side_effect = lambda **kwargs: [b] if kwargs["Class"] is a else [] + + graph = build_nx_graph_from_cl_ontology(cl_ontology=ontology, cl_classes=[a, b]) + + assert "CL:0000000" in graph.nodes + assert "CL:0000001" in graph.nodes + + +def test_build_nx_graph_edges_parent_to_child(): + """Edges are directed parent → child, not child → parent.""" + a = _make_mock_class("CL_0000000", "cell") + b = _make_mock_class("CL_0000001", "somatic cell") + + ontology = MagicMock() + ontology.get_parents_of.side_effect = lambda entity: [a] if entity is b else [] + ontology.get_children_of.side_effect = lambda **kwargs: [b] if kwargs["Class"] is a else [] + + graph = build_nx_graph_from_cl_ontology(cl_ontology=ontology, cl_classes=[a, b]) + + assert graph.has_edge("CL:0000000", "CL:0000001") + assert not graph.has_edge("CL:0000001", "CL:0000000") + + +def test_build_nx_graph_excludes_out_of_set_parents(): + """Classes outside the filtered CL set are ignored and create no edges.""" + a = _make_mock_class("CL_0000000", "cell") + b = _make_mock_class("CL_0000001", "somatic cell") + external = _make_mock_class("GO_0000000", "external") + + ontology = MagicMock() + ontology.get_parents_of.side_effect = lambda entity: [external] if entity is b else [] + ontology.get_children_of.return_value = [] + + graph = build_nx_graph_from_cl_ontology(cl_ontology=ontology, cl_classes=[a, b]) + + assert graph.number_of_edges() == 0 + + +def test_build_ancestors_dictionary_root_has_no_ancestors(): + """The ontology root (CL:0000000) has no ancestors.""" + g = _make_simple_graph() + cl_names = sorted(g.nodes) + idx_map = {n: i for i, n in enumerate(cl_names)} + result = build_ancestors_dictionary(g, cl_names, idx_map) + assert result["CL:0000000"] == [] + + +def test_build_ancestors_dictionary_leaf_includes_all_ancestors(): + """Every node on the path from root to a leaf appears in its ancestor list.""" + g = _make_deep_graph() + cl_names = sorted(g.nodes) + idx_map = {n: i for i, n in enumerate(cl_names)} + result = build_ancestors_dictionary(g, cl_names, idx_map) + assert set(result["CL:0000003"]) == {"CL:0000000", "CL:0000001", "CL:0000002"} + + +def test_build_ancestors_dictionary_ordering_follows_idx_map(): + """Ancestors are returned in ascending cl_names index order, not arbitrary set order.""" + g = _make_deep_graph() + cl_names = sorted(g.nodes) + idx_map = {n: i for i, n in enumerate(cl_names)} + result = build_ancestors_dictionary(g, cl_names, idx_map) + ancestors = result["CL:0000003"] + assert ancestors == [cl_names[idx_map[a]] for a in sorted(ancestors, key=lambda x: idx_map[x])] + + +def test_build_ancestors_dictionary_all_keys_present(): + """Every CL term in the graph has an entry in the output dictionary.""" + g = _make_simple_graph() + cl_names = sorted(g.nodes) + idx_map = {n: i for i, n in enumerate(cl_names)} + result = build_ancestors_dictionary(g, cl_names, idx_map) + assert set(result.keys()) == set(cl_names) + + +def test_build_children_dictionary_root_has_correct_children(): + """Root's direct children are the two nodes immediately below it in the DAG.""" + g = _make_simple_graph() + cl_names = sorted(g.nodes) + result = build_children_dictionary(g, cl_names) + assert set(result["CL:0000000"]) == {"CL:0000001", "CL:0000003"} + + +def test_build_children_dictionary_leaf_has_empty_list(): + """Leaf nodes have an empty children list, not a missing key.""" + g = _make_simple_graph() + cl_names = sorted(g.nodes) + result = build_children_dictionary(g, cl_names) + assert result["CL:0000002"] == [] + + +def test_build_children_dictionary_values_are_sorted(): + """Children lists are lexicographically sorted for deterministic output.""" + g = _make_simple_graph() + cl_names = sorted(g.nodes) + result = build_children_dictionary(g, cl_names) + for children in result.values(): + assert children == sorted(children) + + +def test_build_children_dictionary_all_keys_present(): + """Every CL term in the graph has an entry, including internal and leaf nodes.""" + g = _make_deep_graph() + cl_names = sorted(g.nodes) + result = build_children_dictionary(g, cl_names) + assert set(result.keys()) == set(cl_names) + + +def test_shortest_path_root_is_zero(): + """CL:0000000 has a path length of 0 from itself.""" + g = _make_deep_graph() + result = compute_shortest_path_lengths_from_root(g) + assert result[CELL_ROOT] == 0 + + +def test_shortest_path_linear_chain(): + """Each hop along a linear chain increments the path length by 1.""" + g = _make_deep_graph() + result = compute_shortest_path_lengths_from_root(g) + assert result["CL:0000001"] == 1 + assert result["CL:0000002"] == 2 + assert result["CL:0000003"] == 3 + + +def test_shortest_path_diamond_takes_shorter(): + """ + root → A (len 1) + root → B → A is shorter via root→A directly. + Diamond: root→A→C and root→B→C — shortest to C is 2. + """ + g = nx.DiGraph() + g.add_edges_from( + [ + (CELL_ROOT, "CL:0000001"), # root → A, len 1 + (CELL_ROOT, "CL:0000002"), # root → B, len 1 + ("CL:0000001", "CL:0000003"), # A → C, len 2 + ("CL:0000002", "CL:0000003"), # B → C, len 2 + ] + ) + result = compute_shortest_path_lengths_from_root(g) + assert result["CL:0000003"] == 2 + + +def test_shortest_path_excludes_unreachable_nodes(): + """Nodes with no path from the root are absent from the result.""" + g = _make_deep_graph() + g.add_node("CL:9999999") # disconnected + result = compute_shortest_path_lengths_from_root(g) + assert "CL:9999999" not in result + + +def test_longest_path_root_is_zero(): + """CL:0000000 has a longest path length of 0 from itself.""" + g = _make_deep_graph() + result = compute_longest_path_lengths_from_root(g) + assert result[CELL_ROOT] == 0 + + +def test_longest_path_linear_chain(): + """On a linear chain, longest path equals shortest path at each node.""" + g = _make_deep_graph() + result = compute_longest_path_lengths_from_root(g) + assert result["CL:0000003"] == 3 + + +def test_longest_path_prefers_longer_route(): + """ + root → A (len 1) → C (len 2) + root → B (len 1) → A (len 2) → C (len 3) + Longest path to C should be 3. + """ + g = nx.DiGraph() + g.add_edges_from( + [ + (CELL_ROOT, "CL:0000001"), # root → A + (CELL_ROOT, "CL:0000002"), # root → B + ("CL:0000002", "CL:0000001"), # B → A (makes A reachable at depth 2) + ("CL:0000001", "CL:0000003"), # A → C + ] + ) + result = compute_longest_path_lengths_from_root(g) + assert result["CL:0000003"] == 3 + + +def test_longest_path_excludes_unreachable_nodes(): + """Nodes with no path from the root are absent from the result.""" + g = _make_deep_graph() + g.add_node("CL:9999999") # disconnected + result = compute_longest_path_lengths_from_root(g) + assert "CL:9999999" not in result + + +def _make_mock_cl_class(name: str, label: str) -> MagicMock: + obj = MagicMock() + obj.name = name + obj.label = [label] + obj.__hash__ = lambda self: hash(name) + obj.__eq__ = lambda self, other: getattr(other, "name", None) == name + return obj + + +@pytest.fixture +def minimal_ontology_mock(): + """ + Three-node ontology: root → somatic → T cell (linear chain). + CL_0000000 → CL_0000003 → CL_0000084 + """ + root = _make_mock_cl_class("CL_0000000", "cell") + somatic = _make_mock_cl_class("CL_0000003", "somatic cell") + tcell = _make_mock_cl_class("CL_0000084", "T cell") + classes = [root, somatic, tcell] + + def get_parents_of(entity): + if entity is somatic: + return [root] + if entity is tcell: + return [somatic] + return [] + + def get_children_of(**kwargs): + cl = kwargs["Class"] + if cl is root: + return [somatic] + if cl is somatic: + return [tcell] + return [] + + ontology = MagicMock() + ontology.classes.return_value = iter(classes) + ontology.get_parents_of.side_effect = get_parents_of + ontology.get_children_of.side_effect = get_children_of + return ontology + + +def test_main_writes_valid_json(minimal_ontology_mock): + """CLI produces a JSON file containing exactly the five expected top-level keys.""" + runner = CliRunner() + with tempfile.TemporaryDirectory() as tmpdir: + output_path = str(Path(tmpdir) / "resource.json") + with patch("scripts.create_cell_ontology_resource.owlready2") as mock_owlready2: + mock_owlready2.get_ontology.return_value.load.return_value = minimal_ontology_mock + result = runner.invoke(main, ["--owl-url", "fake://cl.owl", "--output", output_path]) + + assert result.exit_code == 0, result.output + with open(output_path) as f: + data = json.load(f) + + assert set(data.keys()) == { + "ancestors_dictionary", + "cell_ontology_term_id_to_cell_type", + "children_dictionary", + "shortest_path_lengths_from_cell_root", + "longest_path_lengths_from_cell_root", + } + + +def test_main_output_uses_cl_colon_format(minimal_ontology_mock): + """All ontology term keys in the output use CL: format, not the owlready2 CL_ format.""" + runner = CliRunner() + with tempfile.TemporaryDirectory() as tmpdir: + output_path = str(Path(tmpdir) / "resource.json") + with patch("scripts.create_cell_ontology_resource.owlready2") as mock_owlready2: + mock_owlready2.get_ontology.return_value.load.return_value = minimal_ontology_mock + runner.invoke(main, ["--owl-url", "fake://cl.owl", "--output", output_path]) + + with open(output_path) as f: + data = json.load(f) + + for key in data["ancestors_dictionary"]: + assert key.startswith("CL:"), f"Found non-CL: key: {key}" + for key in data["cell_ontology_term_id_to_cell_type"]: + assert key.startswith("CL:"), f"Found non-CL: key: {key}" + + +def test_main_ancestors_of_root_are_empty(minimal_ontology_mock): + """The ontology root has no ancestors in the output JSON.""" + runner = CliRunner() + with tempfile.TemporaryDirectory() as tmpdir: + output_path = str(Path(tmpdir) / "resource.json") + with patch("scripts.create_cell_ontology_resource.owlready2") as mock_owlready2: + mock_owlready2.get_ontology.return_value.load.return_value = minimal_ontology_mock + runner.invoke(main, ["--owl-url", "fake://cl.owl", "--output", output_path]) + + with open(output_path) as f: + data = json.load(f) + + assert data["ancestors_dictionary"]["CL:0000000"] == [] + + +def test_main_shortest_and_longest_agree_on_linear_chain(minimal_ontology_mock): + """On a linear chain (no branching), shortest and longest path lengths are identical.""" + runner = CliRunner() + with tempfile.TemporaryDirectory() as tmpdir: + output_path = str(Path(tmpdir) / "resource.json") + with patch("scripts.create_cell_ontology_resource.owlready2") as mock_owlready2: + mock_owlready2.get_ontology.return_value.load.return_value = minimal_ontology_mock + runner.invoke(main, ["--owl-url", "fake://cl.owl", "--output", output_path]) + + with open(output_path) as f: + data = json.load(f) + + # Linear chain — shortest == longest for every node + shortest = data["shortest_path_lengths_from_cell_root"] + longest = data["longest_path_lengths_from_cell_root"] + for key in shortest: + assert shortest[key] == longest[key], f"Mismatch for {key}" + + +def test_main_missing_required_args_fails(): + """Invoking CLI without required arguments exits with a non-zero status.""" + runner = CliRunner() + result = runner.invoke(main, []) + assert result.exit_code != 0 diff --git a/tests/unit/test_cellarium_general_service.py b/tests/unit/test_cellarium_general_service.py index 4f6e2be6..82f1ff5a 100644 --- a/tests/unit/test_cellarium_general_service.py +++ b/tests/unit/test_cellarium_general_service.py @@ -2,27 +2,222 @@ Tests things in the cellarium_general_service that can reasonably be tested with a unit test. """ +import json +import typing as t + from mockito import mock, unstub import pytest +from cellarium.cas_backend.apps.compute.schemas import CellOntologyResourceResponse +from cellarium.cas_backend.apps.compute.schemas.cellarium_general import CASModel as CASModelSchema +from cellarium.cas_backend.apps.compute.schemas.cellarium_general import OntologicalColumnInfo from cellarium.cas_backend.apps.compute.services.cellarium_general_service import CellariumGeneralService +from cellarium.cas_backend.apps.compute.services.consensus_engine.strategies.ontology_aware import CellOntologyResource from cellarium.cas_backend.apps.compute.services.exceptions import InvalidClientVersionException from cellarium.cas_backend.core import constants -class TestCellariumGeneralService: - def setup_method(self) -> None: - self.cellarium_general_service = CellariumGeneralService(cellarium_general_dm=mock()) +@pytest.fixture +def cellarium_general_service(): + service = CellariumGeneralService(cellarium_general_dm=mock()) + yield service + unstub() + + +@pytest.fixture +def ontology_resource_dict() -> dict[str, t.Any]: + filepath = "tests/unit/test_consensus_engine_fixtures/cell_ontology_resource_mini.json" + with open(filepath) as f: + return json.load(f) + + +@pytest.fixture +def ontology_resource(ontology_resource_dict) -> CellOntologyResource: + return CellOntologyResource(cell_ontology_resource_dict=ontology_resource_dict) + + +def test_validate_client_version_valid(cellarium_general_service): + """A version matching the minimum required version is accepted.""" + assert cellarium_general_service.validate_client_version(constants.MIN_CLIENT_VERSION) + + +def test_validate_client_version_too_old(cellarium_general_service): + """A version below the minimum returns False without raising.""" + assert not cellarium_general_service.validate_client_version("1.3.0") + + +def test_validate_client_version_invalid(cellarium_general_service): + """A non-semver string raises InvalidClientVersionException.""" + with pytest.raises(InvalidClientVersionException): + cellarium_general_service.validate_client_version("invalid_version") + + +def test_cl_names_is_sorted(ontology_resource): + """cl_names are in lexicographic order for stable downstream enumeration.""" + assert ontology_resource.cl_names == sorted(ontology_resource.cl_names) + + +def test_cl_names_contains_all_term_ids(ontology_resource, ontology_resource_dict): + """cl_names covers exactly the same terms as cell_ontology_term_id_to_cell_type.""" + assert set(ontology_resource.cl_names) == set(ontology_resource_dict["cell_ontology_term_id_to_cell_type"].keys()) + + +def test_children_dictionary_loaded(ontology_resource, ontology_resource_dict): + """children_dictionary is populated and matches the raw fixture data.""" + assert ontology_resource.children_dictionary is not None + assert ontology_resource.children_dictionary == ontology_resource_dict["children_dictionary"] + + +def test_shortest_path_lengths_loaded(ontology_resource): + """shortest_path_lengths_from_cell_root is populated and root has length 0.""" + assert ontology_resource.shortest_path_lengths_from_cell_root is not None + assert ontology_resource.shortest_path_lengths_from_cell_root["CL:0000000"] == 0 + + +def test_longest_path_lengths_loaded(ontology_resource): + """longest_path_lengths_from_cell_root is populated and root has length 0.""" + assert ontology_resource.longest_path_lengths_from_cell_root is not None + assert ontology_resource.longest_path_lengths_from_cell_root["CL:0000000"] == 0 + + +def test_new_fields_optional_when_missing(ontology_resource_dict): + """CellOntologyResource can be built from a legacy dict missing the three new fields.""" + minimal_dict = { + "ancestors_dictionary": ontology_resource_dict["ancestors_dictionary"], + "cell_ontology_term_id_to_cell_type": ontology_resource_dict["cell_ontology_term_id_to_cell_type"], + } + resource = CellOntologyResource(cell_ontology_resource_dict=minimal_dict) + assert resource.children_dictionary is None + assert resource.shortest_path_lengths_from_cell_root is None + assert resource.longest_path_lengths_from_cell_root is None + + +def test_response_has_correct_keys(ontology_resource): + """Serialized response contains exactly the five public fields; ancestors_dictionary is excluded.""" + response = CellOntologyResourceResponse( + cl_names=ontology_resource.cl_names, + cell_ontology_term_id_to_cell_type=ontology_resource.ontology_term_id_to_name_dict, + children_dictionary=ontology_resource.children_dictionary, + shortest_path_lengths_from_cell_root=ontology_resource.shortest_path_lengths_from_cell_root, + longest_path_lengths_from_cell_root=ontology_resource.longest_path_lengths_from_cell_root, + ) + dumped = response.model_dump() + assert set(dumped.keys()) == { + "cl_names", + "cell_ontology_term_id_to_cell_type", + "children_dictionary", + "shortest_path_lengths_from_cell_root", + "longest_path_lengths_from_cell_root", + } + assert "ancestors_dictionary" not in dumped + + +def test_cl_names_sorted_in_response(ontology_resource): + """cl_names in the serialized response are in lexicographic order.""" + response = CellOntologyResourceResponse( + cl_names=ontology_resource.cl_names, + cell_ontology_term_id_to_cell_type=ontology_resource.ontology_term_id_to_name_dict, + children_dictionary=ontology_resource.children_dictionary, + shortest_path_lengths_from_cell_root=ontology_resource.shortest_path_lengths_from_cell_root, + longest_path_lengths_from_cell_root=ontology_resource.longest_path_lengths_from_cell_root, + ) + assert response.cl_names == sorted(response.cl_names) + + +def test_ontological_column_info_from_attributes(): + """OntologicalColumnInfo is populated correctly from object attributes.""" + + class FakeOntologicalColumn: + ontology_resource_name = "cell_type" + column_name = "cell_type" + description = "Cell type ontology" + + info = OntologicalColumnInfo.model_validate(FakeOntologicalColumn(), from_attributes=True) + assert info.ontology_resource_name == "cell_type" + assert info.column_name == "cell_type" + assert info.description == "Cell type ontology" + + +def test_ontological_column_info_description_optional(): + """OntologicalColumnInfo description defaults to None when not set.""" + + class FakeOntologicalColumn: + ontology_resource_name = "disease" + column_name = "disease" + description = None + + info = OntologicalColumnInfo.model_validate(FakeOntologicalColumn(), from_attributes=True) + assert info.description is None + + +def test_cas_model_ontological_columns_populated(): + """CASModel reads ontological_columns via AliasPath through cell_info_metadata.""" + + class FakeColumn: + ontology_resource_name = "cell_type" + column_name = "cell_type" + description = "Cell type ontology" + + class FakeCellInfoMetadata: + ontological_columns = [FakeColumn()] + + class FakeCASModel: + model_name = "human-pca-001" + description = "Test model" + schema_name = "refdata-gex-GRCh38-2020-A" + is_default_model = False + embedding_dimension = 512 + cell_info_metadata = FakeCellInfoMetadata() + + schema = CASModelSchema.model_validate(FakeCASModel(), from_attributes=True) + assert len(schema.ontological_columns) == 1 + assert schema.ontological_columns[0].ontology_resource_name == "cell_type" + assert schema.ontological_columns[0].column_name == "cell_type" + assert schema.ontological_columns[0].description == "Cell type ontology" + + +def test_cas_model_ontological_columns_empty_list(): + """CASModel ontological_columns defaults to an empty list when cell_info_metadata has none.""" + + class FakeCellInfoMetadata: + ontological_columns = [] + + class FakeCASModel: + model_name = "human-pca-001" + description = "Test model" + schema_name = "refdata-gex-GRCh38-2020-A" + is_default_model = False + embedding_dimension = 512 + cell_info_metadata = FakeCellInfoMetadata() + + schema = CASModelSchema.model_validate(FakeCASModel(), from_attributes=True) + assert schema.ontological_columns == [] + + +def test_cas_model_multiple_ontological_columns(): + """CASModel includes all ontological columns when multiple are associated.""" - def teardown_method(self) -> None: - unstub() + class FakeColumn: + def __init__(self, name, col, desc): + self.ontology_resource_name = name + self.column_name = col + self.description = desc - def test_validate_client_version_valid(self): - assert self.cellarium_general_service.validate_client_version(constants.MIN_CLIENT_VERSION) + class FakeCellInfoMetadata: + ontological_columns = [ + FakeColumn("cell_type", "cell_type", "Cell type"), + FakeColumn("disease", "disease", None), + ] - def test_validate_client_version_too_old(self): - assert not self.cellarium_general_service.validate_client_version("1.3.0") + class FakeCASModel: + model_name = "human-pca-001" + description = "Test model" + schema_name = "refdata-gex-GRCh38-2020-A" + is_default_model = False + embedding_dimension = 512 + cell_info_metadata = FakeCellInfoMetadata() - def test_validate_client_version_invalid(self): - with pytest.raises(InvalidClientVersionException): - self.cellarium_general_service.validate_client_version("invalid_version") + schema = CASModelSchema.model_validate(FakeCASModel(), from_attributes=True) + assert len(schema.ontological_columns) == 2 + names = {c.ontology_resource_name for c in schema.ontological_columns} + assert names == {"cell_type", "disease"} diff --git a/tests/unit/test_consensus_engine_fixtures/cell_ontology_resource_mini.json b/tests/unit/test_consensus_engine_fixtures/cell_ontology_resource_mini.json index f67568d3..b9bb909d 100644 --- a/tests/unit/test_consensus_engine_fixtures/cell_ontology_resource_mini.json +++ b/tests/unit/test_consensus_engine_fixtures/cell_ontology_resource_mini.json @@ -1,121 +1,169 @@ { "ancestors_dictionary": { - "CL_0000000": [], - "CL_0000003": [ - "CL_0000000" + "CL:0000000": [], + "CL:0000003": [ + "CL:0000000" ], - "CL_0000548": [ - "CL_0000000", - "CL_0000003", - "CL_0000255" + "CL:0000548": [ + "CL:0000000", + "CL:0000003", + "CL:0000255" ], - "CL_0000988": [ - "CL_0000000", - "CL_0000003", - "CL_0000548", - "CL_0002371", - "CL_0000255" + "CL:0000988": [ + "CL:0000000", + "CL:0000003", + "CL:0000548", + "CL:0002371", + "CL:0000255" ], - "CL_0002371": [ - "CL_0000000", - "CL_0000003" + "CL:0002371": [ + "CL:0000000", + "CL:0000003" ], - "CL_0000738": [ - "CL_0000000", - "CL_0000003", - "CL_0000548", - "CL_0000988", - "CL_0002371", - "CL_0000219", - "CL_0002242", - "CL_0000255" + "CL:0000738": [ + "CL:0000000", + "CL:0000003", + "CL:0000548", + "CL:0000988", + "CL:0002371", + "CL:0000219", + "CL:0002242", + "CL:0000255" ], - "CL_0000084": [ - "CL_0000000", - "CL_0000003", - "CL_0000548", - "CL_0000988", - "CL_0002371", - "CL_0000738", - "CL_0000542", - "CL_0000226", - "CL_0000219", - "CL_0002242", - "CL_0000255", - "CL_0000842" + "CL:0000084": [ + "CL:0000000", + "CL:0000003", + "CL:0000548", + "CL:0000988", + "CL:0002371", + "CL:0000738", + "CL:0000542", + "CL:0000226", + "CL:0000219", + "CL:0002242", + "CL:0000255", + "CL:0000842" ], - "CL_0000542": [ - "CL_0000000", - "CL_0000003", - "CL_0000548", - "CL_0000988", - "CL_0002371", - "CL_0000738", - "CL_0000226", - "CL_0000219", - "CL_0002242", - "CL_0000255", - "CL_0000842" + "CL:0000542": [ + "CL:0000000", + "CL:0000003", + "CL:0000548", + "CL:0000988", + "CL:0002371", + "CL:0000738", + "CL:0000226", + "CL:0000219", + "CL:0002242", + "CL:0000255", + "CL:0000842" ], - "CL_0000226": [ - "CL_0000000", - "CL_0000003", - "CL_0002242" + "CL:0000226": [ + "CL:0000000", + "CL:0000003", + "CL:0002242" ], - "CL_0000219": [ - "CL_0000000", - "CL_0000003" + "CL:0000219": [ + "CL:0000000", + "CL:0000003" ], - "CL_0002242": [ - "CL_0000000", - "CL_0000003" + "CL:0002242": [ + "CL:0000000", + "CL:0000003" ], - "CL_0000255": [ - "CL_0000000", - "CL_0000003" + "CL:0000255": [ + "CL:0000000", + "CL:0000003" ], - "CL_0000842": [ - "CL_0000000", - "CL_0000003", - "CL_0000548", - "CL_0000988", - "CL_0002371", - "CL_0000738", - "CL_0000226", - "CL_0000219", - "CL_0002242", - "CL_0000255" + "CL:0000842": [ + "CL:0000000", + "CL:0000003", + "CL:0000548", + "CL:0000988", + "CL:0002371", + "CL:0000738", + "CL:0000226", + "CL:0000219", + "CL:0002242", + "CL:0000255" ], - "CL_0000789": [ - "CL_0000000", - "CL_0000003", - "CL_0000548", - "CL_0000988", - "CL_0002371", - "CL_0000738", - "CL_0000084", - "CL_0000542", - "CL_0000226", - "CL_0000219", - "CL_0002242", - "CL_0000255", - "CL_0000842" + "CL:0000789": [ + "CL:0000000", + "CL:0000003", + "CL:0000548", + "CL:0000988", + "CL:0002371", + "CL:0000738", + "CL:0000084", + "CL:0000542", + "CL:0000226", + "CL:0000219", + "CL:0002242", + "CL:0000255", + "CL:0000842" ] }, "cell_ontology_term_id_to_cell_type": { - "CL_0000000": "cell", - "CL_0000003": "native cell", - "CL_0000548": "animal cell", - "CL_0000988": "hematopoietic cell", - "CL_0002371": "somatic cell", - "CL_0000738": "leukocyte", - "CL_0000084": "T cell", - "CL_0000542": "lymphocyte", - "CL_0000226": "single nucleate cell", - "CL_0000219": "motile cell", - "CL_0002242": "nucleate cell", - "CL_0000255": "eukaryotic cell", - "CL_0000842": "mononuclear cell", - "CL_0000789": "alpha-beta T cell" + "CL:0000000": "cell", + "CL:0000003": "native cell", + "CL:0000548": "animal cell", + "CL:0000988": "hematopoietic cell", + "CL:0002371": "somatic cell", + "CL:0000738": "leukocyte", + "CL:0000084": "T cell", + "CL:0000542": "lymphocyte", + "CL:0000226": "single nucleate cell", + "CL:0000219": "motile cell", + "CL:0002242": "nucleate cell", + "CL:0000255": "eukaryotic cell", + "CL:0000842": "mononuclear cell", + "CL:0000789": "alpha-beta T cell" + }, + "children_dictionary": { + "CL:0000000": ["CL:0000003"], + "CL:0000003": ["CL:0000219", "CL:0000255", "CL:0002242", "CL:0002371"], + "CL:0000084": ["CL:0000789"], + "CL:0000219": ["CL:0000738"], + "CL:0000226": ["CL:0000842"], + "CL:0000255": ["CL:0000548"], + "CL:0000542": ["CL:0000084"], + "CL:0000548": ["CL:0000988"], + "CL:0000738": ["CL:0000842"], + "CL:0000789": [], + "CL:0000842": ["CL:0000542"], + "CL:0000988": ["CL:0000738"], + "CL:0002242": ["CL:0000226", "CL:0000738"], + "CL:0002371": ["CL:0000988"] + }, + "shortest_path_lengths_from_cell_root": { + "CL:0000000": 0, + "CL:0000003": 1, + "CL:0000084": 6, + "CL:0000219": 2, + "CL:0000226": 3, + "CL:0000255": 2, + "CL:0000542": 5, + "CL:0000548": 3, + "CL:0000738": 3, + "CL:0000789": 7, + "CL:0000842": 4, + "CL:0000988": 3, + "CL:0002242": 2, + "CL:0002371": 2 + }, + "longest_path_lengths_from_cell_root": { + "CL:0000000": 0, + "CL:0000003": 1, + "CL:0000084": 8, + "CL:0000219": 2, + "CL:0000226": 3, + "CL:0000255": 2, + "CL:0000542": 7, + "CL:0000548": 3, + "CL:0000738": 5, + "CL:0000789": 9, + "CL:0000842": 6, + "CL:0000988": 4, + "CL:0002242": 2, + "CL:0002371": 2 } } \ No newline at end of file diff --git a/tests/unit/test_consensus_engine_fixtures/ontology_aware_expected_response.json b/tests/unit/test_consensus_engine_fixtures/ontology_aware_expected_response.json index 96694656..de073da6 100644 --- a/tests/unit/test_consensus_engine_fixtures/ontology_aware_expected_response.json +++ b/tests/unit/test_consensus_engine_fixtures/ontology_aware_expected_response.json @@ -4,72 +4,72 @@ "matches": [ { "score": 1, - "cell_type_ontology_term_id": "CL_0000000", + "cell_type_ontology_term_id": "CL:0000000", "cell_type": "cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000003", + "cell_type_ontology_term_id": "CL:0000003", "cell_type": "native cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000548", + "cell_type_ontology_term_id": "CL:0000548", "cell_type": "animal cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000988", + "cell_type_ontology_term_id": "CL:0000988", "cell_type": "hematopoietic cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0002371", + "cell_type_ontology_term_id": "CL:0002371", "cell_type": "somatic cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000738", + "cell_type_ontology_term_id": "CL:0000738", "cell_type": "leukocyte" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000084", + "cell_type_ontology_term_id": "CL:0000084", "cell_type": "T cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000542", + "cell_type_ontology_term_id": "CL:0000542", "cell_type": "lymphocyte" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000226", + "cell_type_ontology_term_id": "CL:0000226", "cell_type": "single nucleate cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000219", + "cell_type_ontology_term_id": "CL:0000219", "cell_type": "motile cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0002242", + "cell_type_ontology_term_id": "CL:0002242", "cell_type": "nucleate cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000255", + "cell_type_ontology_term_id": "CL:0000255", "cell_type": "eukaryotic cell" }, { "score": 1, - "cell_type_ontology_term_id": "CL_0000842", + "cell_type_ontology_term_id": "CL:0000842", "cell_type": "mononuclear cell" }, { "score": 0.4915262351434047, - "cell_type_ontology_term_id": "CL_0000789", + "cell_type_ontology_term_id": "CL:0000789", "cell_type": "alpha-beta T cell" } ],