diff --git a/src/mono/CMakeLists.txt b/src/mono/CMakeLists.txt
index d46df3a77a3b87..47dc6aecf82c64 100644
--- a/src/mono/CMakeLists.txt
+++ b/src/mono/CMakeLists.txt
@@ -330,13 +330,6 @@ elseif(TARGET_SYSTEM_NAME STREQUAL "ios" OR TARGET_SYSTEM_NAME STREQUAL "tvos")
   elseif(TARGET_SYSTEM_NAME STREQUAL "tvos")
     set(TARGET_TVOS 1)
   endif()
-elseif(TARGET_SYSTEM_NAME STREQUAL "linux")
-  set(TARGET_UNIX 1)
-  set(TARGET_LINUX 1)
-elseif(TARGET_SYSTEM_NAME STREQUAL "alpine")
-  set(TARGET_UNIX 1)
-  set(TARGET_LINUX 1)
-  set(TARGET_LINUX_MUSL 1)
 elseif(TARGET_SYSTEM_NAME STREQUAL "android")
   set(TARGET_UNIX 1)
   set(TARGET_LINUX_BIONIC 1)
@@ -344,6 +337,13 @@ elseif(TARGET_SYSTEM_NAME STREQUAL "android")
   if (CMAKE_BUILD_TYPE STREQUAL "Release")
     add_compile_options(-O2)
   endif()
+elseif(CLR_CMAKE_TARGET_LINUX_MUSL)
+  set(TARGET_UNIX 1)
+  set(TARGET_LINUX 1)
+  set(TARGET_LINUX_MUSL 1)
+elseif(TARGET_SYSTEM_NAME STREQUAL "linux")
+  set(TARGET_UNIX 1)
+  set(TARGET_LINUX 1)
 elseif(TARGET_SYSTEM_NAME STREQUAL "emscripten")
   set(TARGET_BROWSER 1)
   if (CMAKE_BUILD_TYPE STREQUAL "Release")
diff --git a/src/mono/mono/mini/mini-arm.h b/src/mono/mono/mini/mini-arm.h
index 73bcc8bb8bb4b8..1d1a6af8b67a52 100644
--- a/src/mono/mono/mini/mini-arm.h
+++ b/src/mono/mono/mini/mini-arm.h
@@ -371,7 +371,7 @@ typedef struct MonoCompileArch {
 #define MONO_ARCH_HAVE_INTERP_PINVOKE_TRAMP 1
 #define MONO_ARCH_HAVE_INTERP_NATIVE_TO_MANAGED 1
 
-#if defined(TARGET_WATCHOS) || (defined(__linux__) && !defined(TARGET_ANDROID))
+#if defined(TARGET_WATCHOS) || (defined(__linux__) && !defined(TARGET_ANDROID) && !defined(TARGET_LINUX_MUSL))
 #define MONO_ARCH_DISABLE_HW_TRAPS 1
 #define MONO_ARCH_HAVE_UNWIND_BACKTRACE 1
 #endif