diff --git a/crates/duckdb/src/inner_connection.rs b/crates/duckdb/src/inner_connection.rs
index f9d50c1c..4cf40bb9 100644
--- a/crates/duckdb/src/inner_connection.rs
+++ b/crates/duckdb/src/inner_connection.rs
@@ -3,6 +3,7 @@ use std::{
     mem,
     os::raw::c_char,
     ptr, str,
+    sync::{Arc, Mutex},
 };
 
 use super::{ffi, Appender, Config, Connection, Result};
@@ -15,6 +16,7 @@ use crate::{
 pub struct InnerConnection {
     pub db: ffi::duckdb_database,
     pub con: ffi::duckdb_connection,
+    interrupt: Arc<InterruptHandle>,
     owned: bool,
 }
 
@@ -30,7 +32,14 @@ impl InnerConnection {
                 Some("connect error".to_owned()),
             ));
         }
-        Ok(InnerConnection { db, con, owned })
+        let interrupt = Arc::new(InterruptHandle::new(con));
+
+        Ok(InnerConnection {
+            db,
+            con,
+            interrupt,
+            owned,
+        })
     }
 
     pub fn open_with_flags(c_path: &CStr, config: Config) -> Result<InnerConnection> {
@@ -57,6 +66,7 @@ impl InnerConnection {
         unsafe {
             ffi::duckdb_disconnect(&mut self.con);
             self.con = ptr::null_mut();
+            self.interrupt.clear();
 
             if self.owned {
                 ffi::duckdb_close(&mut self.db);
@@ -106,6 +116,10 @@ impl InnerConnection {
         Ok(Appender::new(conn, c_app))
     }
 
+    pub fn get_interrupt_handle(&self) -> Arc<InterruptHandle> {
+        self.interrupt.clone()
+    }
+
     #[inline]
     pub fn is_autocommit(&self) -> bool {
         true
@@ -126,3 +140,37 @@ impl Drop for InnerConnection {
         }
     }
 }
+
+/// A handle that allows interrupting long-running queries.
+pub struct InterruptHandle {
+    conn: Mutex<ffi::duckdb_connection>,
+}
+
+unsafe impl Send for InterruptHandle {}
+unsafe impl Sync for InterruptHandle {}
+
+impl InterruptHandle {
+    fn new(conn: ffi::duckdb_connection) -> Self {
+        Self { conn: Mutex::new(conn) }
+    }
+
+    fn clear(&self) {
+        *(self.conn.lock().unwrap()) = ptr::null_mut();
+    }
+
+    /// Interrupt the query currently running on the connection this handle was
+    /// obtained from. The interrupt will cause that query to fail with
+    /// `Error::DuckDBFailure`. If the connection was dropped after obtaining
+    /// this interrupt handle, calling this method results in a noop.
+    ///
+    /// See [`crate::Connection::interrupt_handle`] for an example.
+    pub fn interrupt(&self) {
+        let db_handle = self.conn.lock().unwrap();
+
+        if !db_handle.is_null() {
+            unsafe {
+                ffi::duckdb_interrupt(*db_handle);
+            }
+        }
+    }
+}
diff --git a/crates/duckdb/src/lib.rs b/crates/duckdb/src/lib.rs
index b7d796bd..46c5e770 100644
--- a/crates/duckdb/src/lib.rs
+++ b/crates/duckdb/src/lib.rs
@@ -79,6 +79,7 @@ pub use crate::{
     config::{AccessMode, Config, DefaultNullOrder, DefaultOrder},
     error::Error,
     ffi::ErrorCode,
+    inner_connection::InterruptHandle,
     params::{params_from_iter, Params, ParamsFromIter},
     row::{AndThenRows, Map, MappedRows, Row, RowIndex, Rows},
     statement::Statement,
@@ -532,6 +533,30 @@ impl Connection {
         self.db.borrow_mut().appender(self, table, schema)
     }
 
+    /// Get a handle to interrupt long-running queries.
+    ///
+    /// ## Example
+    ///
+    /// ```rust,no_run
+    /// # use duckdb::{Connection, Result};
+    /// fn run_query(conn: Connection) -> Result<()> {
+    ///   let interrupt_handle = conn.interrupt_handle();
+    ///   let join_handle = std::thread::spawn(move || { conn.execute("expensive query", []) });
+    ///
+    ///   // Arbitrary wait for query to start
+    ///   std::thread::sleep(std::time::Duration::from_millis(100));
+    ///
+    ///   interrupt_handle.interrupt();
+    ///
+    ///   let query_result = join_handle.join().unwrap();
+    ///   assert!(query_result.is_err());
+    ///
+    ///   Ok(())
+    /// }
+    pub fn interrupt_handle(&self) -> std::sync::Arc<InterruptHandle> {
+        self.db.borrow().get_interrupt_handle()
+    }
+
     /// Close the DuckDB connection.
     ///
     /// This is functionally equivalent to the `Drop` implementation for
@@ -1337,6 +1362,36 @@ mod test {
         Ok(())
     }
 
+    #[test]
+    fn test_interrupt() -> Result<()> {
+        let db = checked_memory_handle();
+        let db_interrupt = db.interrupt_handle();
+
+        let (tx, rx) = std::sync::mpsc::channel();
+        std::thread::spawn(move || {
+            let mut stmt = db
+                .prepare("select count(*) from range(10000000) t1, range(1000000) t2")
+                .unwrap();
+            tx.send(stmt.execute([])).unwrap();
+        });
+
+        std::thread::sleep(std::time::Duration::from_millis(100));
+        db_interrupt.interrupt();
+
+        let result = rx.recv_timeout(std::time::Duration::from_secs(5)).unwrap();
+        assert!(result.is_err_and(|err| err.to_string().contains("INTERRUPT")));
+        Ok(())
+    }
+
+    #[test]
+    fn test_interrupt_on_dropped_db() {
+        let db = checked_memory_handle();
+        let db_interrupt = db.interrupt_handle();
+
+        drop(db);
+        db_interrupt.interrupt();
+    }
+
     #[cfg(feature = "bundled")]
     #[test]
     fn test_version() -> Result<()> {