diff --git a/Cargo.lock b/Cargo.lock
index 0cf47febc3..7a9c35d88d 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1,5 +1,7 @@
 # This file is automatically @generated by Cargo.
 # It is not intended for manual editing.
+version = 3
+
 [[package]]
 name = "ahash"
 version = "0.4.7"
@@ -159,6 +161,12 @@ dependencies = [
  "proc-macro-hack",
 ]
 
+[[package]]
+name = "indoc"
+version = "1.0.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "05a0bd019339e5d968b37855180087b7b9d512c5046fbd244cf8c95687927d6e"
+
 [[package]]
 name = "indoc-impl"
 version = "0.3.6"
@@ -306,9 +314,15 @@ dependencies = [
  "ndarray",
  "num-complex",
  "num-traits",
- "pyo3",
+ "pyo3 0.12.4",
 ]
 
+[[package]]
+name = "once_cell"
+version = "1.10.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "87f3e037eac156d1775da914196f0f37741a274155e34a0b7e427c35d2a2ecb9"
+
 [[package]]
 name = "parking_lot"
 version = "0.11.1"
@@ -391,8 +405,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "bf6bbbe8f70d179260b3728e5d04eb012f4f0c7988e58c11433dd689cecaa72e"
 dependencies = [
  "ctor",
- "hashbrown",
- "indoc",
+ "indoc 0.3.6",
  "inventory",
  "libc",
  "parking_lot",
@@ -401,6 +414,33 @@ dependencies = [
  "unindent",
 ]
 
+[[package]]
+name = "pyo3"
+version = "0.16.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1e6302e85060011447471887705bb7838f14aba43fcb06957d823739a496b3dc"
+dependencies = [
+ "cfg-if 1.0.0",
+ "hashbrown",
+ "indoc 1.0.6",
+ "libc",
+ "parking_lot",
+ "pyo3-build-config",
+ "pyo3-ffi",
+ "pyo3-macros",
+ "unindent",
+]
+
+[[package]]
+name = "pyo3-build-config"
+version = "0.16.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b5b65b546c35d8a3b1b2f0ddbac7c6a569d759f357f2b9df884f5d6b719152c8"
+dependencies = [
+ "once_cell",
+ "target-lexicon",
+]
+
 [[package]]
 name = "pyo3-derive-backend"
 version = "0.12.4"
@@ -412,6 +452,39 @@ dependencies = [
  "syn",
 ]
 
+[[package]]
+name = "pyo3-ffi"
+version = "0.16.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c275a07127c1aca33031a563e384ffdd485aee34ef131116fcd58e3430d1742b"
+dependencies = [
+ "libc",
+ "pyo3-build-config",
+]
+
+[[package]]
+name = "pyo3-macros"
+version = "0.16.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "284fc4485bfbcc9850a6d661d627783f18d19c2ab55880b021671c4ba83e90f7"
+dependencies = [
+ "proc-macro2",
+ "pyo3-macros-backend",
+ "quote",
+ "syn",
+]
+
+[[package]]
+name = "pyo3-macros-backend"
+version = "0.16.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "53bda0f58f73f5c5429693c96ed57f7abdb38fdfc28ae06da4101a257adb7faf"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn",
+]
+
 [[package]]
 name = "pyo3cls"
 version = "0.12.4"
@@ -527,7 +600,7 @@ dependencies = [
  "ndarray",
  "numpy",
  "petgraph",
- "pyo3",
+ "pyo3 0.16.5",
  "rand",
  "rand_pcg",
  "rayon",
@@ -556,6 +629,12 @@ dependencies = [
  "unicode-xid",
 ]
 
+[[package]]
+name = "target-lexicon"
+version = "0.12.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d7fa7e55043acb85fca6b3c01485a2eeb6b69c5d21002e273c79e465f43b7ac1"
+
 [[package]]
 name = "unicode-xid"
 version = "0.2.1"
diff --git a/Cargo.toml b/Cargo.toml
index 6fa1831bc2..9162f6c210 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -25,7 +25,7 @@ rand_pcg = "0.3"
 rayon = "1.5"
 
 [dependencies.pyo3]
-version = "0.12.3"
+version = "0.16.5"
 features = ["extension-module", "hashbrown"]
 
 [dependencies.hashbrown]