Access_DB_Daten_TSV.csv

PubMed ID	URL	PDF	First Author	Authors	Year	Journal	Judgement	Outcome category	Outcome subcategory	Animal	Animal subtype	Animal age	Animal gender	Animal weight	Injury height	Injury type	Outcome name	Outcome further detail name	Outcome further detail value	Injury location	Injury device	Injury device detail	Treatment type	Treatment detail	Treatment application	Treatment  dosage	Injured treated	Injured control	Sham control	Trend	Timepoint	Animal weight, lightest (g)	Animal weight, heaviest (g)	BBB timepoint (days)	BBB value (Treated)	BBB value (Control)
1613809	1613809		Martinez-Arizala	Martinez-Arizala A, Green BA.	1992	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Cyst volume	hemorrhage			Weight drop	50 g x cm	Systemic	Hypothermia		31-32_C	3	3		Decrease		>=200, <300	>=300, <400			
1613809	1613809		Martinez-Arizala	Martinez-Arizala A, Green BA.	1992	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Non-neuronal cells pathol.	parenchymal damage			Weight drop	50 g x cm	Systemic	Hypothermia		31-32_C	3	3		Decrease		>=200, <300	>=300, <400			
1613809	1613809		Martinez-Arizala	Martinez-Arizala A, Green BA.	1992	J Neurotrauma	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Open field	no functional benefit			Weight drop	50 g x cm	Systemic	Hypothermia		31-32_C	3	3		No change	4 d	>=200, <300	>=300, <400			
1810564	1810564		Simpson	Simpson RK Jr, Baskin DS, Dudley AW, Bogue L, Rothenberg F.	1991	J Spinal Disord	Positive	Functional	Electrophysiology	Rat	SD	Adult	Not defined	250-350 g	Thoracic	Contusion	Motor evoked potentials				Weight drop	50 g x cm	Systemic	Indomethacin	Intraperitoneal	2 mg/kg	10	12		Increase		>=200, <300	>=300, <400			
1810564	1810564		Simpson	Simpson RK Jr, Baskin DS, Dudley AW, Bogue L, Rothenberg F.	1991	J Spinal Disord	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	250-350 g	Thoracic	Contusion	Inclined plane test				Weight drop	50 g x cm	Systemic	Indomethacin	Intraperitoneal	2 mg/kg	10	12		Increase	6 w	>=200, <300	>=300, <400			
1810564	1810564		Simpson	Simpson RK Jr, Baskin DS, Dudley AW, Bogue L, Rothenberg F.	1991	J Spinal Disord	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	250-350 g	Thoracic	Contusion	Lesion volume	histopathological changes in the spinal cord (tissue loss)			Weight drop	50 g x cm	Systemic	Indomethacin	Intraperitoneal	2 mg/kg	10	12		Decrease	6 w	>=200, <300	>=300, <400			
1810564	1810564		Simpson	Simpson RK Jr, Baskin DS, Dudley AW, Bogue L, Rothenberg F.	1991	J Spinal Disord	No effect	Functional	Electrophysiology	Rat	SD	Adult	Not defined	250-350 g	Thoracic	Contusion	Somatosensory evoked potentials				Weight drop	50 g x cm	Systemic	Indomethacin	Intraperitoneal	2 mg/kg	10	12		No change		>=200, <300	>=300, <400			
1810564	1810564		Simpson	Simpson RK Jr, Baskin DS, Dudley AW, Bogue L, Rothenberg F.	1991	J Spinal Disord	No effect	Functional	Sensory test	Rat	SD	Adult	Not defined	250-350 g	Thoracic	Contusion	Hindpaw sensation				Weight drop	50 g x cm	Systemic	Indomethacin	Intraperitoneal	2 mg/kg	10	12		No change		>=200, <300	>=300, <400			
3143469	3143469	Open PDF	Faden	Faden AI, Lemke M, Demediuk P.	1988	Brain Res	Positive	Non-functional	Inflammation	Rat	SD	Adult	Not defined	275-325 g	Thoracic	Contusion	Prostaglandins	thromboxane B2 (TxB2) level in tissue			Weight drop	50 g x cm	Systemic	BW755C	Intravenous	10 mg/kg	8	8		Decrease		>=200, <300	>=300, <400			
3143469	3143469	Open PDF	Faden	Faden AI, Lemke M, Demediuk P.	1988	Brain Res	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	275-325 g	Thoracic	Contusion	Inclined plane test				Weight drop	50 g x cm	Systemic	BW755C	Intravenous	10 mg/kg	15	15		Increase		>=200, <300	>=300, <400			
3143469	3143469	Open PDF	Faden	Faden AI, Lemke M, Demediuk P.	1988	Brain Res	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	275-325 g	Thoracic	Contusion	Open field				Weight drop	50 g x cm	Systemic	BW755C	Intravenous	10 mg/kg	15	15		Increase		>=200, <300	>=300, <400			
3143469	3143469	Open PDF	Faden	Faden AI, Lemke M, Demediuk P.	1988	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	275-325 g	Thoracic	Contusion	Cyst volume	edema			Weight drop	50 g x cm	Systemic	BW755C	Intravenous	10 mg/kg	8	8		No change		>=200, <300	>=300, <400			
3143469	3143469	Open PDF	Faden	Faden AI, Lemke M, Demediuk P.	1988	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	275-325 g	Thoracic	Contusion	Toxicity	Cation content in spinal cord			Weight drop	50 g x cm	Systemic	BW755C	Intravenous	10 mg/kg	8	8		No change		>=200, <300	>=300, <400			
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	4.12 [2.39]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	10	9		Increase	3 w	>=100, <200	>=200, <300		4,12	2,39
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	28.3 [57.7]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		Decrease	3 w	>=100, <200	>=200, <300		28,3	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.15 [1.62]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		Decrease	3 w	>=100, <200	>=200, <300		1,15	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of ventral white matter spared tissue [_m]	724  [53]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	10	9		Decrease	3 w	>=100, <200	>=200, <300		724	53
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.33 [1.89]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	10	9		Decrease	3 w	>=100, <200	>=200, <300		1,33	1,89
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	38.2 [57.7]		No.5 Dumont forceps		Systemic	Lipopolysaccharide	Intraperitoneal	0.2 mg	4	6		Decrease	3 w	>=100, <200	>=200, <300		38,2	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	25.6 [57.7]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		Decrease	3 w	>=100, <200	>=200, <300		25,6	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	4.50 [2.25]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		Increase	3 w	>=100, <200	>=200, <300		4,5	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	35.7 [52.6]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	10	9		Decrease	3 w	>=100, <200	>=200, <300		35,7	52,6
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.12 [1.62]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		Decrease	3 w	>=100, <200	>=200, <300		1,12	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	29.8 [57.7]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	4	6		Decrease	3 w	>=100, <200	>=200, <300		29,8	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	3.50 [2.39]		No.5 Dumont forceps		Systemic	Acetylsalicylic acid	Subcutaneous	1.19 mg	10	9		Increase	3 w	>=100, <200	>=200, <300		3,5	2,39
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of ventral white matter spared tissue [_m]	214  [53]		No.5 Dumont forceps		Systemic	Acetylsalicylic acid	Subcutaneous	1.19 mg	10	9		Decrease	3 w	>=100, <200	>=200, <300		214	53
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	3.15 [2.39]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	10	9		Increase	3 w	>=100, <200	>=200, <300		3,15	2,39
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	54.6 [57.7]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	6	6		No change	3 w	>=100, <200	>=200, <300		54,6	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	64.0 [57.7]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		No change	3 w	>=100, <200	>=200, <300		64	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.84 [1.62]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	6	6		No change	3 w	>=100, <200	>=200, <300		1,84	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	3.29 [2.25]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		No change	3 w	>=100, <200	>=200, <300		3,29	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	2.92 [2.25]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	6	6		No change	3 w	>=100, <200	>=200, <300		2,92	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	3.20 [2.25]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	4	6		No change	3 w	>=100, <200	>=200, <300		3,2	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	2.58 [2.25]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		No change	3 w	>=100, <200	>=200, <300		2,58	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.64 [1.62]		No.5 Dumont forceps		Systemic	Lipopolysaccharide	Intraperitoneal	0.2 mg	4	6		No change	3 w	>=100, <200	>=200, <300		1,64	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.68 [1.62]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	6	6		No change	3 w	>=100, <200	>=200, <300		1,68	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of ventral white matter spared tissue [_m]	131 [53]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	10	9		No change	3 w	>=100, <200	>=200, <300		131	53
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.63 [1.62]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	4	6		No change	3 w	>=100, <200	>=200, <300		1,63	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	3.50 [2.25]		No.5 Dumont forceps		Systemic	Lipopolysaccharide	Intraperitoneal	0.2 mg	4	6		No change	3 w	>=100, <200	>=200, <300		3,5	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.63 [1.89]		No.5 Dumont forceps		Systemic	Acetylsalicylic acid	Subcutaneous	1.19 mg	10	9		No change	3 w	>=100, <200	>=200, <300		1,63	1,89
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	51.7 [52.6]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	10	9		No change	3 w	>=100, <200	>=200, <300		51,7	52,6
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.61 [1.62]		No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		No change	3 w	>=100, <200	>=200, <300		1,61	1,62
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	44.5 [52.6]		No.5 Dumont forceps		Systemic	Acetylsalicylic acid	Subcutaneous	1.19 mg	10	9		No change	3 w	>=100, <200	>=200, <300		44,5	52,6
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Cyst volume	Area of cavity/area of lesion x 100	55.4 [57.7]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	6	6		No change	3 w	>=100, <200	>=200, <300		55,4	57,7
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Lesion volume	Area of lesion [mm2]	1.77 [1.89]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	10	9		No change	3 w	>=100, <200	>=200, <300		1,77	1,89
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Open field	modified Tarlov Scale	3.25 [2.25]		No.5 Dumont forceps		Systemic	Steroid	Subcutaneous	2.38 mg	6	6		No change	3 w	>=100, <200	>=200, <300		3,25	2,25
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Negative	Functional	Physiology	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Survival	4 of 8 died			No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	4	6		Decrease	3 w	>=100, <200	>=200, <300			
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Negative	Functional	Physiology	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Survival	1 of 5 died			No.5 Dumont forceps		Systemic	Lipopolysaccharide	Intraperitoneal	0.2 mg	4	6		Decrease	3 w	>=100, <200	>=200, <300			
7991623	7991623	Open PDF	Guth	Guth L, Zhang Z, Roberts E.	1994	PNAS	Negative	Functional	Physiology	Rat	SD	Adult	Female	170-200g	Thoracic	Compression	Survival	2 of 8 died			No.5 Dumont forceps		Systemic	Indomethacin	Intraperitoneal	0.2 mg	6	6		Decrease	3 w	>=100, <200	>=200, <300			
8115048	8115048	Open PDF	Sharma	Sharma HS, Olsson Y, Nyberg F, Dey PK.	1993	Neuroscience	Positive	Non-functional	Molecular changes	Rat	Wistar	Adult	Not defined		Thoracic	Partial transection	Neurotransmitter content	photometric measurement of serotonin content in spinal cord and serum		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	n/a	n/a		Decrease						
8115048	8115048	Open PDF	Sharma	Sharma HS, Olsson Y, Nyberg F, Dey PK.	1993	Neuroscience	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined		Thoracic	Partial transection	Cyst volume	edema		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	n/a	n/a		Decrease						
8115048	8115048	Open PDF	Sharma	Sharma HS, Olsson Y, Nyberg F, Dey PK.	1993	Neuroscience	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined		Thoracic	Partial transection	Toxicity	microvascular permeability		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	n/a	n/a		Decrease						
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Lesion volume	sponginess of tissue		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	1,5 mg/kg	5	5		Decrease		>=200, <300	>=300, <400			
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Myelination	immunostaining for MBP (myelin basic protein)		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	5	5		Increase		>=200, <300	>=300, <400			
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Lesion volume	sponginess of tissue		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	5	5		Decrease		>=200, <300	>=300, <400			
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Axonal damage	number of neurons with cytological changes		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	5	5		Decrease		>=200, <300	>=300, <400			
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Cyst volume	spinal cord edema		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	5	5		Decrease		>=200, <300	>=300, <400			
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Myelination	immunostaining for MBP (myelin basic protein)		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	1,5 mg/kg	5	5		Increase		>=200, <300	>=300, <400			
8442406	8442406	Open PDF	Sharma	Sharma HS, Olsson Y, Cerv_s-Navarro J.	1993	Acta Neuropathol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	200-300 g	Thoracic	Partial transection	Axonal damage	number of neurons with cytological changes		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	1,5 mg/kg	5	5		Decrease		>=200, <300	>=300, <400			
8450974	8450974	Open PDF	Winkler	Winkler T, Sharma HS, St_lberg E, Olsson Y.	1993	Neuroscience	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	350-400 g	Thoracic	Partial transection	Cyst volume	edema		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	11	6		Decrease		>=300, <400	>=400, <500			
8450974	8450974	Open PDF	Winkler	Winkler T, Sharma HS, St_lberg E, Olsson Y.	1993	Neuroscience	Positive	Functional	Electrophysiology	Rat	SD	Adult	Male	350-400 g	Thoracic	Partial transection	Spinal cord evoked potentials	recording intraspinally, excitation in leg muscles, amplitude compared		Right dorsal horn, 2 mm deep			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	11	6		Increase	0;1;2;3;4;5 h	>=300, <400	>=400, <500			
8730788	8730788		Stutzmann	Stutzmann JM, Pratt J, Boraud T, Gross C.	1996	Neuroreport	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	280  g	Thoracic	Compression	Cyst volume	hemorrhage within the sub-dural space			Fogarty balloon catheter	2.5 bars	Systemic	Riluzole	Intravenous	2 mg/kg	10	10		Decrease		>=200, <300	>=200, <300			
8730788	8730788		Stutzmann	Stutzmann JM, Pratt J, Boraud T, Gross C.	1996	Neuroreport	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	280  g	Thoracic	Compression	Open field	use of paws to sit upright			Fogarty balloon catheter	2.5 bars	Systemic	Riluzole	Intravenous	2 mg/kg	10	10		Increase		>=200, <300	>=200, <300			
8730788	8730788		Stutzmann	Stutzmann JM, Pratt J, Boraud T, Gross C.	1996	Neuroreport	Positive	Functional	Electrophysiology	Rat	Wistar	Adult	Male	280  g	Thoracic	Compression	Somatosensory evoked potentials	somatosensory evoked potentials (SSEP) amplitude, duration and latency			Fogarty balloon catheter	2.5 bars	Systemic	Riluzole	Intravenous	2 mg/kg	10	10		Increase		>=200, <300	>=200, <300			
8730788	8730788		Stutzmann	Stutzmann JM, Pratt J, Boraud T, Gross C.	1996	Neuroreport	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	280 g	Thoracic	Compression	Lesion volume	necrosis of (grey and) white matter			Fogarty balloon catheter	2.5 bars	Systemic	Riluzole	Intravenous	2 mg/kg	10	10		Decrease		>=200, <300	>=200, <300			
9048312	9048312	Open PDF	Farooque	Farooque M, Hillered L, Holtz A, Olsson Y.	1997	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	360 g	Thoracic	Compression	Toxicity	lactate levels (microdialysis)				Severe cord	Systemic	Hypothermia		30-31_C	6	6		No change		>=300, <400	>=300, <400			
9326288	9326288	Open PDF	Springer	Springer JE, Azbill RD, Kennedy SE, George J, Geddes JW.	1997	J Neurochem	Positive	Non-functional	Molecular changes	Rat	Not defined	Not defined	Not defined		Thoracic	Contusion	Cytoskeletal integrity	MAP2 levels increase after lesion			NYU impactor	25 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	6	6		Increase	1 d					
9631482	9631482	Open PDF	Yamamoto	Yamamoto K, Ishikawa T, Sakabe T, Taguchi T, Kawai S, Marsala M.	1998	Neuroreport	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	350-375 g	Cervical	Compression	Toxicity	CSF glutamate levels (microdialysis)			Balloon	Epidural	Systemic	Hypothermia		33_C	5	5		Decrease		>=300, <400	>=300, <400			
9872457	9872457	Open PDF	Resnick	Resnick DK, Graham SH, Dixon CE, Marion DW.	1998	J Neurotrauma	Positive	Functional	Locomotor test	Rat	Long-Evans	Adult	Male	275-340 g	Thoracic	Contusion	BBB				NYU impactor	25 gxcm	Systemic	SC58125	Oral	3 mg/kg	8	8		Increase		>=200, <300	>=300, <400	28	11	9
9872457	9872457	Open PDF	Resnick	Resnick DK, Graham SH, Dixon CE, Marion DW.	1998	J Neurotrauma	Positive	Functional	Locomotor test	Rat	Long-Evans	Adult	Male	275-340 g	Thoracic	Contusion	BBB				NYU impactor	12.5 gxcm	Systemic	SC58125	Oral	3 mg/kg	8	8		Increase		>=200, <300	>=300, <400	28	16	15
9872457	9872457	Open PDF	Resnick	Resnick DK, Graham SH, Dixon CE, Marion DW.	1998	J Neurotrauma	No effect	Non-functional	Inflammation	Rat	Long-Evans	Adult	Male	275-340 g	Thoracic	Contusion	Pro-inflammatory Cytokine	COX2 expression			NYU impactor	12.5 or 25 g x cm	Systemic	SC58125	Oral	3 mg/kg	8	8		Increase	2d	>=200, <300	>=300, <400			
9872457	9872457	Open PDF	Resnick	Resnick DK, Graham SH, Dixon CE, Marion DW.	1998	J Neurotrauma	No effect	Non-functional	Inflammation	Rat	Long-Evans	Adult	Male	275-340 g	Thoracic	Contusion	Pro-inflammatory Cytokine	COX2 expression in neurons and blood vessels			NYU impactor	12.5 or 25 g x cm	Systemic	SC58125	Oral	3 mg/kg	8	8		Increase		>=200, <300	>=300, <400			
10412796	10412796	Open PDF	Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y.	1999	Acta Neuropathol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	387 g	Thoracic	Compression	Lesion volume	fibronectin, possible reason: less vasogenic edema				50 g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400			
10412796	10412796	Open PDF	Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y.	1999	Acta Neuropathol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	387  g	Thoracic	Compression	Lesion volume	cord cross sectional area, possible reason: reduced edema				50 g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400			
10412796	10412796	Open PDF	Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y.	1999	Acta Neuropathol	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	387 g	Thoracic	Compression	Inflammation	albumin, possible reason: less vasogenic edema				50 g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400			
10412796	10412796	Open PDF	Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y.	1999	Acta Neuropathol	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	387 g	Thoracic	Compression	Inflammation	fibrinogen, possible reason: less vasogenic edema				50 g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400			
10438114	10438114	Open PDF	S_zer	S_zer T, Coskun E, Islekel H, Tahta K.	1999	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rat	albino	Adult	Male	210-310 g	Thoracic	Compression	Oxidative stress	lipid peroxidation (MDA levels)			Extradural Aneurysm Clip	50 g	Systemic	Magnesium	Subcutaneous	600 mg/kg	10	10		Decrease	1 d	>=200, <300	>=300, <400			
10438114	10438114	Open PDF	S_zer	S_zer T, Coskun E, Islekel H, Tahta K.	1999	Spinal Cord	Positive	Functional	Electrophysiology	Rat	albino	Adult	Male	210-310 g	Thoracic	Compression	Somatosensory evoked potentials				Extradural Aneurysm Clip	50 g	Systemic	Magnesium	Subcutaneous	600 mg/kg	10	10		Increase	3h	>=200, <300	>=300, <400			
10438114	10438114	Open PDF	S_zer	S_zer T, Coskun E, Islekel H, Tahta K.	1999	Spinal Cord	No effect	Non-functional	Secondary degeneration	Rat	albino	Adult	Male	210-310 g	Thoracic	Compression	Oxidative stress	lipid peroxidation (MDA levels)			Extradural Aneurysm Clip	50 g	Systemic	Magnesium	Subcutaneous	300 mg/kg	10	10		No change	1 d	>=200, <300	>=300, <400			
10438114	10438114	Open PDF	S_zer	S_zer T, Coskun E, Islekel H, Tahta K.	1999	Spinal Cord	No effect	Functional	Electrophysiology	Rat	albino	Adult	Male	210-310 g	Thoracic	Compression	Somatosensory evoked potentials				Extradural Aneurysm Clip	50 g	Systemic	Magnesium	Subcutaneous	300 mg/kg	10	10		No change	3h	>=200, <300	>=300, <400			
10543012	10543012	Open PDF	Thomas	Thomas AJ, Nockels RP, Pan HQ, Shaffrey CI, Chopp M.	1999	Spine	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	295-305 g	Thoracic	Contusion	Lesion volume	intact white matter [%]	 53 [31]		NYU impactor	10 g x 25 mm	Systemic	Progesterone	Intraperitoneal	4 mg/kg	10	10		Decrease	6 w	>=200, <300	>=300, <400		53	31
10543012	10543012	Open PDF	Thomas	Thomas AJ, Nockels RP, Pan HQ, Shaffrey CI, Chopp M.	1999	Spine	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	295-305 g	Thoracic	Contusion	BBB		15.5 [10.3]		NYU impactor	10 g x 25 mm	Systemic	Progesterone	Intraperitoneal	4 mg/kg	10	10		Increase	6 w	>=200, <300	>=300, <400	42	15,5	10,3
10557125	10557125	Open PDF	Westergren	Westergren H, Yu WR, Farooque M, Holtz A, Olsson Y.	1999	Spinal Cord	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	387  g	Thoracic	Compression	Axonal damage	b-APP				50 g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400			
10557125	10557125	Open PDF	Westergren	Westergren H, Yu WR, Farooque M, Holtz A, Olsson Y.	1999	Spinal Cord	No effect	Non-functional	Neuroprotection	Rat	SD	Adult	Male	387  g	Thoracic	Compression	Other	PGP9.5				50 g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400			
10705928	10705928	Open PDF	Guven	Guven MB, Cirak B, Yuceer N, Ozveren F.	1999	Pediatr Neurosurg	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	160-200 g	Thoracic	Compression	Oxidative stress	lipid peroxidation (absorption of thiobarbituric acid reactive substances)			Aneurysm Clip	150 g	Systemic	Indomethacin	Intraperitoneal	3 mg/kg	8	8		Increase		>=100, <200	>=200, <300			
10776915	10776915		Chatzipanteli	Chatzipanteli K, Yanagawa Y, Marcillo AE, Kraydieh S, Yezierski RP, Dietrich WD.	2000	J Neurotrauma	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Inflammatory cells	myeloperoxidase (neutrophil accumulation)	511.3 [143.1]		NYU impactor	10 g x 12.5 mm	Systemic	Hypothermia		32_C	4	4	4	Decrease		>=200, <300	>=300, <400		511,3	143,1
10790883	10790883	Open PDF	Yick	Yick LW, Wu W, So KF, Yip HK, Shum DK.	2000	Neuroreport	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	% of Clarke neurons retrogradely labeled with Fluoro-Gold	5.8 [0]	Hemisection			Local	Chondroitinase ABC	Gelfoam	10 _l at 1,0 U/ml = 0,01 U	6	6		Increase		>=200, <300	>=200, <300		5,8	0
10790883	10790883	Open PDF	Yick	Yick LW, Wu W, So KF, Yip HK, Shum DK.	2000	Neuroreport	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	% of Clarke neurons retrogradely labeled with Fluoro-Gold	2 [0]	Hemisection			Local	Chondroitinase ABC	Gelfoam	10 _l at 2,5 U/ml = 0,025 U	8	6		Increase		>=200, <300	>=200, <300		2	0
10790883	10790883	Open PDF	Yick	Yick LW, Wu W, So KF, Yip HK, Shum DK.	2000	Neuroreport	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	% of Clarke neurons retrogradely labeled with Fluoro-Gold	12.8 [0]	Hemisection			Local	Chondroitinase ABC	Gelfoam	10 _l at 5,0 U/ml = 0,05 U	6	6		Increase		>=200, <300	>=200, <300		12,8	0
10869502	10869502	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	Brain Res	Positive	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	Oxidative stress	synaptosomes examined, improvement of mitochondrial function			NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		Decrease	4 h	>=200, <300	>=200, <300			
10869502	10869502	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	Brain Res	Positive	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	Oxidative stress	decrease of MDA level, improvement of mitochondrial function, reactive oxygen species level, thiobarbituric acid reactive product level, glutamate and glucose levels			NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		Decrease		>=200, <300	>=200, <300			
10869502	10869502	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	Brain Res	Positive	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	Oxidative stress	synaptosomes examined, enhancement of glutamate and glucose uptake			NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		Decrease	4 h	>=200, <300	>=200, <300			
10879763	10879763		Yu, CG	Yu CG, Jimenez O, Marcillo AE, Weider B, Bangerter K, Dietrich WD, Castro S, Yezierski RP.	2000	J_Neurosurg	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	225-275 g	Thoracic	Contusion	BBB		13.3 [10.8]		NYU impactor	10 g x 12.5 mm	Systemic	Hypothermia		32-33_C	19	17		Increase		>=200, <300	>=200, <300	42	13,3	10,8
10879763	10879763		Yu, CG	Yu CG, Jimenez O, Marcillo AE, Weider B, Bangerter K, Dietrich WD, Castro S, Yezierski RP.	2000	J_Neurosurg	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-275 g	Thoracic	Contusion	Lesion volume	16 longitudinal sections through injured cord			NYU impactor	10 g x 12.5 mm	Systemic	Hypothermia		32-33_C	19	17		Decrease	6 w	>=200, <300	>=200, <300			
10898365	10898365	Open PDF	Westergren	Westergren H, Farooque M, Olsson Y, Holtz A.	2000	Acta Neurochir	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	350-500 g	Thoracic	Compression	Inclined plane test					35 g	Systemic	Hypothermia		30_C	14	12		No change	2 w	>=300, <400	>=500			
10898365	10898365	Open PDF	Westergren	Westergren H, Farooque M, Olsson Y, Holtz A.	2000	Acta Neurochir	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	350-500 g	Thoracic	Compression	Open field	hindlimb motor scores				35 g	Systemic	Hypothermia		30_C	14	12		No change	2 w	>=300, <400	>=500			
10908929	10908929	Open PDF	Jou	Jou IM.	2000	Spine	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	290-340 g	Cervical	Compression	Lesion volume	less tissue destruction at injury epicenter			Clip		Systemic	Hypothermia		34_C	12	12		Decrease		>=200, <300	>=300, <400			
10908929	10908929	Open PDF	Jou	Jou IM.	2000	Spine	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	290-340 g	Cervical	Compression	Open field				Clip		Systemic	Hypothermia		34_C	12	12		Increase	3 d	>=200, <300	>=300, <400			
10908929	10908929	Open PDF	Jou	Jou IM.	2000	Spine	Positive	Functional	Electrophysiology	Rat	SD	Adult	Not defined	290-340 g	Cervical	Compression	Somatosensory evoked potentials				Clip		Systemic	Hypothermia		34_C	12	12		Increase	0 h	>=200, <300	>=300, <400			
10925216	10925216	Open PDF	Labombarda	Labombarda F, Gonzalez S, Roig P, Lima A, Guennoun R, Schumacher M, De Nicola AF.	2000	J Steroid Biochem Mol Biol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	SCI rats: number of NADPH-diaphorase active (NOS) astrocytes in grey and white matter above and below the injury but not far caudal to it					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	Decrease	75 h	>=200, <300	>=300, <400			
10925216	10925216	Open PDF	Labombarda	Labombarda F, Gonzalez S, Roig P, Lima A, Guennoun R, Schumacher M, De Nicola AF.	2000	J Steroid Biochem Mol Biol	No effect	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	sham-injured rats: number of GFAP-expressing astrocytes (activated cells) (GFAP increased in all areas measured by SCI alone)					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	Decrease	75 h	>=200, <300	>=300, <400			
11011817	11011817	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	J Neurotrauma	Positive	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	BBB	vehicle = 9,7 and 10,5; Riluzole + MP = 12,5 and 13,7 at 5 and 6w			NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		Increase		>=200, <300	>=200, <300	42	13,5	10,2
11011817	11011817	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	Lesion volume	significantly increased spared tissue			NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		Increase		>=200, <300	>=200, <300			
11011817	11011817	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	J Neurotrauma	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	BBB				NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		No change		>=200, <300	>=200, <300	42	11	10,2
11011817	11011817	Open PDF	Mu	Mu X, Azbill RD, Springer JE.	2000	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	225-250 g	Thoracic	Contusion	Lesion volume	Cavitation			NYU impactor	12.5 mm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	9	9		No change		>=200, <300	>=200, <300			
11031083	11031083	Open PDF	Mabon	Mabon PJ, Weaver LC, Dekaban GA.	2000	Exp Neurol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Complete transection	Inflammatory cells	neutrophils decreased					Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg or 5 mg/kg	8	4		Decrease	2 d	>=200, <300	>=300, <400			
11031083	11031083	Open PDF	Mabon	Mabon PJ, Weaver LC, Dekaban GA.	2000	Exp Neurol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Complete transection	Inflammatory cells	macrophages decreased					Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg or 5 mg/kg	9	4		Decrease	2 d	>=200, <300	>=300, <400			
11031083	11031083	Open PDF	Mabon	Mabon PJ, Weaver LC, Dekaban GA.	2000	Exp Neurol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Complete transection	Inflammatory cells	macrophages decreased					Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg or 5 mg/kg	8	4		Decrease	2 d	>=200, <300	>=300, <400			
11031083	11031083	Open PDF	Mabon	Mabon PJ, Weaver LC, Dekaban GA.	2000	Exp Neurol	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Complete transection	Inflammation						Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg or 5 mg/kg	8	4		No change	2 d	>=200, <300	>=300, <400			
11045677	11045677	Open PDF	Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y.	2000	Acta Neuropathol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	387 g	Thoracic	Compression	Lesion volume	cord cross sectional area, possible reason: reduced edema				35 g	Systemic	Hypothermia		30_C	5	5		Decrease	1 d	>=300, <400	>=300, <400			
11045677	11045677	Open PDF	Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y.	2000	Acta Neuropathol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	387  g	Thoracic	Compression	Neurogenesis	MAP2 immunostaining at injury site				35 g	Systemic	Hypothermia		30_C	5	5		Increase	1 d	>=300, <400	>=300, <400			
11302627	11302627	Open PDF	Schwartz	Schwartz G, Fehlings MG.	2001	J Neurosurg	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	225-280 g	Cervical	Compression	Inclined plane test				Extradural Clip	53 g	Systemic	Riluzole	Intraperitoneal	5 mg/kg	15	15		Increase		>=200, <300	>=200, <300			
11302627	11302627	Open PDF	Schwartz	Schwartz G, Fehlings MG.	2001	J Neurosurg	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	225-280 g	Cervical	Compression	BBB				Extradural Clip	53 g	Systemic	Riluzole	Intraperitoneal	5 mg/kg	15	15		Increase		>=200, <300	>=200, <300	42	11,9	8,7
11302627	11302627	Open PDF	Schwartz	Schwartz G, Fehlings MG.	2001	J Neurosurg	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	225-280 g	Cervical	Compression	Lesion volume	cavitation (LFB and H&E stained transverse spinal cord sections)			Extradural Clip	53 g	Systemic	Riluzole	Intraperitoneal	5 mg/kg	15	15		Decrease		>=200, <300	>=200, <300			
11302627	11302627	Open PDF	Schwartz	Schwartz G, Fehlings MG.	2001	J Neurosurg	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	225-280 g	Cervical	Compression	Axonal regeneration	FG-positive retrograde labeled neurons in the brain stem with significantly more neurons counted within the red nucleus			Extradural Clip	53 g	Systemic	Riluzole	Intraperitoneal	5 mg/kg	15	15		Increase		>=200, <300	>=200, <300			
11336442	11336442	Open PDF	Hains	Hains BC, Yucra JA, Hulsebosch CE.	2001	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-225 g	Thoracic	Contusion	Lesion volume	tissue sparing			NYU Weight Drop	10 g x 12.5 mm	Systemic	NS-398	Intraperitoneal	5 mg/kg	20	20		Increase		>=200, <300	>=200, <300			
11336442	11336442	Open PDF	Hains	Hains BC, Yucra JA, Hulsebosch CE.	2001	J Neurotrauma	Positive	Functional	Sensory test	Rat	SD	Adult	Male	200-225 g	Thoracic	Contusion	Mechanical allodynia				NYU Weight Drop	10 g x 12.5 mm	Systemic	NS-398	Intraperitoneal	5 mg/kg	20	20		Decrease		>=200, <300	>=200, <300			
11336442	11336442	Open PDF	Hains	Hains BC, Yucra JA, Hulsebosch CE.	2001	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	200-225 g	Thoracic	Contusion	BBB	NS-398 vs control: 17,4 vs 14,7			NYU Weight Drop	10 g x 12.5 mm	Systemic	NS-398	Intraperitoneal	5 mg/kg	20	20		Increase		>=200, <300	>=200, <300	28	17,4	14,7
11336442	11336442	Open PDF	Hains	Hains BC, Yucra JA, Hulsebosch CE.	2001	J Neurotrauma	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	200-225 g	Thoracic	Contusion	Pro-inflammatory Cytokine	PGE2 in caudal spinal cord			NYU Weight Drop	10 g x 12.5 mm	Systemic	NS-398	Intraperitoneal	5 mg/kg	20	20		Decrease		>=200, <300	>=200, <300			
11402362	11402362	Open PDF	Westergren	Westergren H, Farooque M, Olsson Y, Holtz A.	2001	Spinal Cord	No effect	Functional	Physiology	Rat	SD	Adult	Male	350-420 g	Thoracic	Compression	Blood circulation	spinal cord blood flow (SCBF), no significant reduction				35 g	Systemic	Hypothermia		30_C	6	6	6	No change		>=300, <400	>=400, <500			
11746451	11746451	Open PDF	Borgens	Borgens RB, Bohnert D.	2001	J Neurosci Res	Positive	Functional	Reflex	Guinea Pig	Not defined	Adult	Not defined	300 g	Thoracic	Crush	Skin muscle reflex	cutaneus trunci muscle (CTM) (skin muscle) reflex			Forceps		Systemic	Polyethylene Glycol (PEG)	Subcutaneous	1 cc of 30% w/w	10	10		Increase		>=300, <400	>=300, <400			
11746451	11746451	Open PDF	Borgens	Borgens RB, Bohnert D.	2001	J Neurosci Res	Positive	Functional	Electrophysiology	Guinea Pig	Not defined	Adult	Not defined	300 g	Thoracic	Crush	Somatosensory evoked potentials				Forceps		Systemic	Polyethylene Glycol (PEG)	Subcutaneous	1 cc of 30% w/w	10	10		Increase		>=300, <400	>=300, <400			
11746451	11746451	Open PDF	Borgens	Borgens RB, Bohnert D.	2001	J Neurosci Res	Positive	Functional	Reflex	Guinea Pig	Not defined	Adult	Not defined	300 g	Thoracic	Crush	Skin muscle reflex	cutaneus trunci muscle (CTM) (skin muscle) reflex			Forceps		Systemic	Polyethylene Glycol (PEG)	Subcutaneous	1 cc of 30% w/w	3	10		Increase		>=300, <400	>=300, <400			
11746451	11746451	Open PDF	Borgens	Borgens RB, Bohnert D.	2001	J Neurosci Res	Positive	Functional	Electrophysiology	Guinea Pig	Not defined	Adult	Not defined	300 g	Thoracic	Crush	Somatosensory evoked potentials				Forceps		Systemic	Polyethylene Glycol (PEG)	Subcutaneous	1 cc of 30% w/w	3	10		Increase		>=300, <400	>=300, <400			
11939502	11939502	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Gonzalez DM, Guennoun R, Schumacher M, de Nicola AF.	2002	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	choline acetyl transferase (ChAT) in motorneurons					Systemic	Progesterone	Subcutaneous	4 mg/kg	6	6	6	Decrease	75 h	>=200, <300	>=300, <400			
11939502	11939502	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Gonzalez DM, Guennoun R, Schumacher M, de Nicola AF.	2002	J Neurotrauma	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Genetic transcription	expression of mRNA for _3 and _1 regulatory subunits of neuronal Na-K-ATPase					Systemic	Progesterone	Subcutaneous	4 mg/kg	6	6	6	Increase	75 h	>=200, <300	>=300, <400			
11939502	11939502	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Gonzalez DM, Guennoun R, Schumacher M, de Nicola AF.	2002	J Neurotrauma	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Protein expression	GAP-43 in motorneurons (upregulation of GAP-13 after SCI, further enhanced by treatment)					Systemic	Progesterone	Subcutaneous	4 mg/kg	6	6	6	Increase	75 h	>=200, <300	>=300, <400			
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	Positive	Functional	Electrophysiology	Rat	Wistar	Adult	Male		Cervical	Crush	Spinal cord evoked potentials	postsynaptic potentials 		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	Increase						
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male		Cervical	Crush	Walking analysis	gridwalk		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	Increase						
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male		Cervical	Crush	Walking analysis	stride width		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	Increase						
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male		Cervical	Crush	Walking analysis	stride length		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	Increase						
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male		Cervical	Crush	Axonal regeneration	CST growth/sprouting		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	Increase						
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male		Cervical	Crush	Walking analysis	beam walk		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	Increase						
11948352	11948352	Open PDF	Bradbury	Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB.	2002	Nature	No effect	Functional	Sensory test	Rat	Wistar	Adult	Male		Cervical	Crush	Tape removal			Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	12	12	12	No change						
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	180-300 g	Thoracic	Contusion	Apoptosis	TUNEL staining; rostral to injury site			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg/d	14	6		Decrease	1 w	>=100, <200	>=300, <400			
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-300 g	Thoracic	Contusion	BBB		18 [10]		Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg/d	14	6		Increase	4 w	>=100, <200	>=300, <400	28	18	10
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	180-300 g	Thoracic	Contusion	Lesion volume	cavitation [relative volume]	0.75 [1]		Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg/d	14	6		Decrease	1 w	>=100, <200	>=300, <400		0,75	1
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-300 g	Thoracic	Compression	Open field				Aneurysm Clip	0.6 N	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg/d	14	6		Increase	1 w	>=100, <200	>=300, <400			
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-300 g	Thoracic	Compression	Open field				Aneurysm Clip	0.6 N	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	14	6		Increase	1 w	>=100, <200	>=300, <400			
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	180-300 g	Thoracic	Contusion	Apoptosis	TUNEL staining; rostral to injury site			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	500 IU/kg/d	14	6		Decrease	1 w	>=100, <200	>=300, <400			
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	180-300 g	Thoracic	Contusion	Lesion volume	cavitation [relative volume]	0.75 [1]		Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	500 IU/kg/d	14	6		Decrease	1 w	>=100, <200	>=300, <400		0,75	1
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-300 g	Thoracic	Compression	Open field				Aneurysm Clip	0.6 N	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	14	6		Increase	4 w	>=100, <200	>=300, <400			
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-300 g	Thoracic	Compression	Open field				Aneurysm Clip	0.6 N	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg/d	14	6		Increase	4 w	>=100, <200	>=300, <400			
12082184	12082184	Open PDF	Gorio	Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A, Brines M.	2002	PNAS	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	180-300 g	Thoracic	Contusion	Open field				Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	500 IU/kg/d	14	6		No change		>=100, <200	>=300, <400			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Functional	Electrophysiology	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Somatosensory evoked potentials			Right dorsal horn			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	6	6		Increase	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Functional	Electrophysiology	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Somatosensory evoked potentials			Right dorsal horn			Systemic	Ibuprofen	Intraperitoneal	10 mg/kg	7	6		Increase	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Functional	Physiology	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Blood circulation	changes in spinal cord blood flow		Right dorsal horn			Systemic	Ibuprofen	Intraperitoneal	10 mg/kg	7	6		Decrease	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Cyst volume	Edema		Right dorsal horn			Systemic	Ibuprofen	Intraperitoneal	10 mg/kg	7	6		Decrease	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Functional	Physiology	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Blood circulation	changes in spinal cord blood flow		Right dorsal horn			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	6	6		Decrease	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Lesion volume	blood-spinal cord barrier (BSCB) permeability		Right dorsal horn			Systemic	Ibuprofen	Intraperitoneal	10 mg/kg	7	6		Decrease	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Cyst volume	Edema		Right dorsal horn			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	6	6		Decrease	5 h	>=300, <400	>=400, <500			
12116291	12116291	Open PDF	Sharma	Sharma HS, Winkler T.	2002	Muscle Nerve	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	350-420 g	Thoracic	Partial transection	Lesion volume	blood-spinal cord barrier (BSCB) permeability		Right dorsal horn			Systemic	Indomethacin	Intraperitoneal	10 mg/kg	6	6		Decrease	5 h	>=300, <400	>=400, <500			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Cyst volume	edema  			Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	Decrease		>=100, <200	>=200, <300			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Axonal damage				Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	Decrease		>=100, <200	>=200, <300			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Open field	Tarlov's motor scale			Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	Increase	1 d	>=100, <200	>=200, <300			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Inclined plane test				Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	Increase	1 d	>=100, <200	>=200, <300			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Other				Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	Increase		>=100, <200	>=200, <300			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	BBB				Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	10	10	10	Increase	1 d	>=100, <200	>=200, <300	1	12,5	5
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Angiogenesis	vascular changes			Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	Decrease		>=100, <200	>=200, <300			
12763339	12763339	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Okutan O, Selcuk Surucu H, Taskin Y.	2003	J Clin Neurosci	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	180-230 g	Thoracic	Contusion	Myelination	axonal myelination			Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	100 or 600 mg/kg	10	10	10	No change		>=100, <200	>=200, <300			
12783273	12783273	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Solaroglu I, Kilinc A, Taskin Y.	2003	Neurosurg Rev	Positive	Functional	Physiology	Rat	SD	Adult	Female	220-270 g	Thoracic	Contusion	Blood brain barrier	blood-spinal cord barrier (BSCB) permeability (Evans blue)			Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	8	8	8	Decrease		>=200, <300	>=200, <300			
12783273	12783273	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Solaroglu I, Kilinc A, Taskin Y.	2003	Neurosurg Rev	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	220-270 g	Thoracic	Contusion	BBB				Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	8	8	8	Increase	1 d	>=200, <300	>=200, <300	1	11,5	8,17
12783273	12783273	Open PDF	Kaptanoglu	Kaptanoglu E, Beskonakli E, Solaroglu I, Kilinc A, Taskin Y.	2003	Neurosurg Rev	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	220-270 g	Thoracic	Contusion	Inclined plane test				Allen Weight Drop	50 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	8	8	8	Increase	1 d	>=200, <300	>=200, <300			
12805103	12805103	Open PDF	Wells	Wells JE, Hurlbert RJ, Fehlings MG, Yong VW.	2003	Brain	Positive	Functional	Physiology	Mouse	CD-1	Adult	Not defined		Thoracic	Compression	Survival				Clip	8 g	Systemic	Minocycline	Intraperitoneal	50mg/kg at 1h, then 25mg/kg 	25	26		Increase	3 w					
12805103	12805103	Open PDF	Wells	Wells JE, Hurlbert RJ, Fehlings MG, Yong VW.	2003	Brain	Positive	Functional	Locomotor test	Mouse	CD-1	Adult	Not defined		Thoracic	Compression	Inclined plane test				Clip	8 g	Systemic	Minocycline	Intraperitoneal	50mg/kg at 1h, then 25mg/kg 	18	15		Increase	4 w					
12805103	12805103	Open PDF	Wells	Wells JE, Hurlbert RJ, Fehlings MG, Yong VW.	2003	Brain	Positive	Non-functional	Neuronal regeneration	Mouse	CD-1	Adult	Not defined		Thoracic	Compression	Axonal regeneration	Nucleus ruber neurons, retrograde tracing with Fluorogold distal to lesion			Clip	8 g	Systemic	Minocycline	Intraperitoneal	50mg/kg at 1h, then 25mg/kg 	11	8		Increase	4 w					
12805103	12805103	Open PDF	Wells	Wells JE, Hurlbert RJ, Fehlings MG, Yong VW.	2003	Brain	Positive	Functional	Locomotor test	Mouse	CD-1	Adult	Not defined		Thoracic	Compression	BBB				Clip	8 g	Systemic	Minocycline	Intraperitoneal	50mg/kg at 1h, then 25mg/kg 	18	15		Increase	4 w			28	10	5
12805103	12805103	Open PDF	Wells	Wells JE, Hurlbert RJ, Fehlings MG, Yong VW.	2003	Brain	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Not defined		Thoracic	Compression	Lesion volume				Clip	8 g	Systemic	Minocycline	Intraperitoneal	50mg/kg at 1h, then 25mg/kg 	6	5		Decrease	4 w					
12821386	12821386	Open PDF	Yick	Yick LW, Cheung PT, So KF, Wu W.	2003	Exp Neurol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female		Thoracic	Partial transection	Axonal regeneration	C7 retrograde labeling of L1 Clarke's neurons [%]	12.3 [0]	Hemisection			Local	Chondroitinase ABC	Gelfoam	10 _l of 2,5 U/ml = 0,025 U	6	n/a	6	Increase					12,3	0
12920606	12920606	Open PDF	Kaptanoglu	Kaptanoglu E, Solaroglu I, Okutan O, Surucu HS, Akbiyik F, Beskonakli E.	2004	Neurosurg Rev	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	215-260 g	Thoracic	Contusion	Lesion volume	5000 IU/kg: protection of spinal cord ultrastructure			Weight drop	50 g x cm	Systemic	Erythropoietin	Intraperitoneal	100, 1000 or 5000 IU/kg	8	8		Increase	2h	>=200, <300	>=200, <300			
12920606	12920606	Open PDF	Kaptanoglu	Kaptanoglu E, Solaroglu I, Okutan O, Surucu HS, Akbiyik F, Beskonakli E.	2004	Neurosurg Rev	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	215-260 g	Thoracic	Contusion	Oxidative stress	5000 IU/kg: reduction of lipid peroxidation			Weight drop	50 g x cm	Systemic	Erythropoietin	Intraperitoneal	100, 1000 or 5000 IU/kg	8	8		Decrease	2h	>=200, <300	>=200, <300			
14588302	14588302	Open PDF	Resnick	Resnick DK, Nguyen P, Cechvala CF.	2001	Spine J	Positive	Non-functional	Inflammation	Rat	Long-Evans	Adult	Not defined		Thoracic	Contusion	Pro-inflammatory Cytokine	PGE2 in spinal cord			NYU impactor	25 g x cm	Systemic	Celebocid	Oral	3 mg/kg	4	not defined		Decrease						
14588302	14588302	Open PDF	Resnick	Resnick DK, Nguyen P, Cechvala CF.	2001	Spine J	Positive	Non-functional	Inflammation	Rat	Long-Evans	Adult	Not defined		Thoracic	Contusion	Prostaglandins	TxB2 in spinal cord			NYU impactor	25 g x cm	Systemic	Celebocid	Oral	3 mg/kg	4	not defined		Decrease						
14622121	14622121	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Deniselle MC, Vinson GP, Schumacher M, De Nicola AF, Guennoun R.	2003	J Neurochem	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	increase of numbers of 25-Dx-immunoreactive neurons					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	10		Decrease	3 d	>=200, <300	>=300, <400			
14622121	14622121	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Deniselle MC, Vinson GP, Schumacher M, De Nicola AF, Guennoun R.	2003	J Neurochem	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Genetic transcription	mRNA expression of 25-Dx (membrane binding site)					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	10		Increase	3 d	>=200, <300	>=300, <400			
14622121	14622121	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Deniselle MC, Vinson GP, Schumacher M, De Nicola AF, Guennoun R.	2003	J Neurochem	No effect	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	numbers of PR-immunoreactive neurons					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	10		No change	3 d	>=200, <300	>=300, <400			
14622121	14622121	Open PDF	Labombarda	Labombarda F, Gonzalez SL, Deniselle MC, Vinson GP, Schumacher M, De Nicola AF, Guennoun R.	2003	J Neurochem	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Genetic transcription	mRNA expression of classical intracellular progesterone receptor (PR)					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	10		No change	3 d	>=200, <300	>=300, <400			
14630702	14630702	Open PDF	Chau	Chau CH, Shum DK, Li H, Pei J, Lui YY, Wirthlin L, Chan YS, Xu XM.	2004	FASEB J	Positive	Non-functional	Neuronal regeneration	Rat	Fischer	Adult	Female		Thoracic	Partial transection	Axonal regeneration	growth caudal to mini-channel with the mean axonal growth in the 7 animals being 3,18 mm +/- 0,98 (other 5 not included)		Hemisection			Local	Chondroitinase ABC	Intrathecal	0,06 U/d	12	12		Increase						
14630702	14630702	Open PDF	Chau	Chau CH, Shum DK, Li H, Pei J, Lui YY, Wirthlin L, Chan YS, Xu XM.	2004	FASEB J	Positive	Non-functional	Secondary degeneration	Rat	Fischer	Adult	Female		Thoracic	Partial transection	Lesion volume	Cavitation		Hemisection			Local	Chondroitinase ABC	Intrathecal	0,06 U/d	12	12		Decrease						
14630702	14630702	Open PDF	Chau	Chau CH, Shum DK, Li H, Pei J, Lui YY, Wirthlin L, Chan YS, Xu XM.	2004	FASEB J	Positive	Non-functional	Neuronal regeneration	Rat	Fischer	Adult	Female		Thoracic	Partial transection	Myelination	number of myelinated axons in the channel,p < 0,002, N=5, control: ~450, ChABC: ~1550		Hemisection			Local	Chondroitinase ABC	Intrathecal	0,06 U/d	12	12		Increase						
14713941	14713941	Open PDF	Shibuya	Shibuya S, Miyamoto O, Janjua NA, Itano T, Mori S, Norimatsu H.	2004	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	320 g	Thoracic	Compression	Apoptosis	TUNEL positive cells around injury				25 g	Systemic	Hypothermia		32_C	15	15	9	Decrease		>=300, <400	>=300, <400			
14981254	14981254	Open PDF	Teng	Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder EY, Eichler ME, Friedlander RM.	2004	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	280-330 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	8, 90, 180 mg/kg	10	10		Increase		>=200, <300	>=300, <400	28	17	13
14981254	14981254	Open PDF	Teng	Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder EY, Eichler ME, Friedlander RM.	2004	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	280-330 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	8, 90, 180 mg/kg	3	3		Decrease	4 w	>=200, <300	>=300, <400			
14981254	14981254	Open PDF	Teng	Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder EY, Eichler ME, Friedlander RM.	2004	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	280-330 g	Thoracic	Contusion	Walking analysis	foot coordination			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	8, 90, 180 mg/kg	3	3		Increase		>=200, <300	>=300, <400			
14981254	14981254	Open PDF	Teng	Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder EY, Eichler ME, Friedlander RM.	2004	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	280-330 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	8, 90, 180 mg/kg	3	3		Decrease	4 w	>=200, <300	>=300, <400			
14981254	14981254	Open PDF	Teng	Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, Woodard EJ, Snyder EY, Eichler ME, Friedlander RM.	2004	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	280-330 g	Thoracic	Contusion	Toxicity				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	8, 90, 180 mg/kg	3	3		Decrease		>=200, <300	>=300, <400			
14999069	14999069	Open PDF	Stirling	Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W.	2004	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Not defined		Cervical	Partial transection	Walking analysis	foot coordination		Dorsal column			Systemic	Minocycline	Intraperitoneal	50 mg/kg	8	8		Increase						
14999069	14999069	Open PDF	Stirling	Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W.	2004	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Not defined		Cervical	Partial transection	Footprint analysis	hindpaw angle rotation		Dorsal column			Systemic	Minocycline	Intraperitoneal	50 mg/kg	8	8		Decrease						
14999069	14999069	Open PDF	Stirling	Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W.	2004	J Neurosci	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Not defined		Cervical	Partial transection	Axonal damage	CST dieback		Dorsal column			Systemic	Minocycline	Intraperitoneal	50 mg/kg	4	4		Decrease						
14999069	14999069	Open PDF	Stirling	Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W.	2004	J Neurosci	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Not defined		Cervical	Partial transection	Inflammatory cells	ED-1 positive microglia/macrophages number		Dorsal column			Systemic	Minocycline	Intraperitoneal	50 mg/kg	4	4		Decrease	1 w					
14999069	14999069	Open PDF	Stirling	Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W.	2004	J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined		Cervical	Partial transection	Apoptosis	glial cell death		Dorsal column			Systemic	Minocycline	Intraperitoneal	50 mg/kg	6	6		Decrease						
15099674	15099674	Open PDF	Gonzalez	Gonz_lez SL, Labombarda F, Gonz_lez Deniselle MC, Guennoun R, Schumacher M, De Nicola AF.	2004	Neuroscience	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Neurotrophic factors	BDNF (mRNA and protein)					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	Increase	75 h	>=200, <300	>=300, <400			
15099674	15099674	Open PDF	Gonzalez	Gonz_lez SL, Labombarda F, Gonz_lez Deniselle MC, Guennoun R, Schumacher M, De Nicola AF.	2004	Neuroscience	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Toxicity	chromatolysis of L1 motoneurons					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	Decrease	75 h	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Walking analysis	gridwalk			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	9	7		Increase	12 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Non-functional	Molecular changes	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Cytoskeletal integrity	neurofilaments			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	7	5		Increase	6 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Myelination				Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	5		Increase	12 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	BBB		8 [7]		Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	7	6		Increase	6 w	>=200, <300	>=300, <400	42	8	7
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Non-functional	Molecular changes	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Cytoskeletal integrity	neurofilaments			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	5		Increase	12 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Lesion volume	tissue sparing			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Decrease		>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Inclined plane test				Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	9	6		Increase	12 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Mechanical allodynia	Trunk stimulation			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	8	7		Decrease	12 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Functional	Physiology	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Autonomic dysreflexia	mean arterial pressure after colon distension			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	7		Decrease	6 w	>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	BBB		9.7 [7.8]		Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	9	6		Increase	12 w	>=200, <300	>=300, <400	84	9,7	7,8
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Lesion volume	tissue sparing			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Decrease		>=200, <300	>=300, <400			
15102919	15102919	Open PDF	Gris	Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.	2004	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Myelination				Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	7	5		Increase	6 w	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	TUNEL			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	300 _g/kg	3	3		Decrease	1 d	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	BBB		18 [15]		NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	8	8		Increase		>=200, <300	>=300, <400	30	18,3	15
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	TUNEL			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	3	3		Decrease	1 d	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Lesion volume				NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	3	3		Decrease		>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	DNA laddering			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	3	3		Decrease	1 d	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	caspase-3 activity			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	3	3		Decrease	4 h	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	DNA laddering			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	300 _g/kg	3	3		Decrease	1 d	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	Bcl-2			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	300 _g/kg	3	3		Increase	1 d	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	Bcl-2			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	3 _g/kg	3	3		Increase	1 d	>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	Bcl-2			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	3	3		Increase		>=200, <300	>=300, <400			
15115604	15115604	Open PDF	Yune	Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH.	2004	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	bcl-2 expression in tissue sections in putative neurons			NYU Weight Drop	10 g x 12.5 mm	Systemic	Estrogen	Intravenous	100 _g/kg	3	3		Increase	1 d	>=200, <300	>=300, <400			
15293235	15293235	Open PDF	Schwab	Schwab JM, Conrad S, Elbert T, Trautmann K, Meyermann R, Schluesener HJ.	2004	Glia	Positive	Non-functional	Neuronal regeneration	Rat	Lewis	Adult	Male	250-300 g	Thoracic	Partial transection	Axonal regeneration	GAP-43+ neurites at injury site		Dorsal spinal cord symmetrical four-fifth			Systemic	Indomethacin	Intraperitoneal	2 mg/kg/day for 3d	5	5		Increase		>=200, <300	>=300, <400			
15293235	15293235	Open PDF	Schwab	Schwab JM, Conrad S, Elbert T, Trautmann K, Meyermann R, Schluesener HJ.	2004	Glia	Positive	Non-functional	Molecular changes	Rat	Lewis	Adult	Male	250-300 g	Thoracic	Partial transection	RhoA activation	number of RhoA+ cells (granulocytes, ED1+ macrophages/microglia, GFAP+ astrocytes)		Dorsal spinal cord symmetrical four-fifth			Systemic	Indomethacin	Intraperitoneal	2 mg/kg/day for 3d	5	5		Decrease		>=200, <300	>=300, <400			
15307905	15307905	Open PDF	Yick	Yick LW, So KF, Cheung PT, Wu WT.	2004	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	200-250 g	Cervical	Partial transection	Forelimb strength	forelimb use in cylinder [%]	29.1 [7.7]	Right hemisection			Local	Chondroitinase ABC	Gelfoam	10 _l of 2,5 U/ml = 0,025 U	4	4		Increase		>=200, <300	>=200, <300		29,1	7,7
15307905	15307905	Open PDF	Yick	Yick LW, So KF, Cheung PT, Wu WT.	2004	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Not defined	200-250 g	Cervical	Partial transection	Axonal regeneration	retrograde tracing (Fluoro-gold) of rubrospinal neurons [%]	22.1 [2.3]	Right hemisection			Local	Chondroitinase ABC	Gelfoam	10 _l of 2,5 U/ml = 0,025 U	5	5		Increase		>=200, <300	>=200, <300		22,1	2,3
15307905	15307905	Open PDF	Yick	Yick LW, So KF, Cheung PT, Wu WT.	2004	J Neurotrauma	No effect	Functional	Locomotor test	Rat	SD	Adult	Not defined	200-250 g	Cervical	Partial transection	Forelimb strength	forelimb use in cylinder [%]	18.1 [7.7]	Right hemisection			Local	Lithium chloride	Gelfoam	85 mg/kg (correct dose in erratum)	4	4		No change		>=200, <300	>=200, <300		18,1	7,7
15307905	15307905	Open PDF	Yick	Yick LW, So KF, Cheung PT, Wu WT.	2004	J Neurotrauma	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Not defined	200-250 g	Cervical	Partial transection	Axonal regeneration	retrograde tracing (Fluoro-gold) of rubrospinal neurons		Right hemisection			Local	Lithium chloride	Gelfoam	85 mg/kg (correct dose in erratum)	5	5		No change		>=200, <300	>=200, <300			
15312174	15312174	Open PDF	Bao	Bao F, Chen Y, Dekaban GA, Weaver LC.	2004	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220 g	Thoracic	Compression	Oxidative stress	reduction of RNA- and DNA oxidation			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	17		Decrease		>=200, <300	>=200, <300			
15312174	15312174	Open PDF	Bao	Bao F, Chen Y, Dekaban GA, Weaver LC.	2004	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220 g	Thoracic	Compression	Oxidative stress	protein carbonylation			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	17		Decrease		>=200, <300	>=200, <300			
15312174	15312174	Open PDF	Bao	Bao F, Chen Y, Dekaban GA, Weaver LC.	2004	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220 g	Thoracic	Compression	Oxidative stress	COX-2			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	17		Decrease		>=200, <300	>=200, <300			
15312174	15312174	Open PDF	Bao	Bao F, Chen Y, Dekaban GA, Weaver LC.	2004	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220 g	Thoracic	Compression	Oxidative stress	increased APE/Ref-1 (DNA repair enzyme)			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	17		Decrease		>=200, <300	>=200, <300			
15456912	15456912	Open PDF	Brines	Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.	2004	PNAS	Positive	Functional	Locomotor test	Mouse	C57/BL6	Adult	Male		Thoracic	Compression	BBB	complete locomotor recovery in WT mice	21 [12]		Steel Rod	15g	Systemic	Erythropoietin	Intraperitoneal	10 _l/kg	10	10		Increase	4 w			28	21	12
15456912	15456912	Open PDF	Brines	Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.	2004	PNAS	No effect	Functional	Locomotor test	Mouse	C57/BL6beta cR knockout	Adult	Male		Thoracic	Compression	BBB		10 [11]		Steel Rod	15g	Systemic	Erythropoietin	Intraperitoneal	10 _l/kg	10	10		No change	6 w			42	10	11
15456912	15456912	Open PDF	Brines	Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.	2004	PNAS	No effect	Functional	Physiology	Mouse	C57/BL6	Adult	Male		Thoracic	Compression	Survival				Steel Rod	15g	Systemic	Erythropoietin	Intraperitoneal	10 _l/kg	10	10		No change	6 w					
15456912	15456912	Open PDF	Brines	Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.	2004	PNAS	No effect	Functional	Physiology	Mouse	C57/BL6beta cR knockout	Adult	Male		Thoracic	Compression	Survival				Steel Rod	15g	Systemic	Erythropoietin	Intraperitoneal	10 _l/kg	10	10		No change	6 w					
15456912	15456912	Open PDF	Brines	Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.	2004	PNAS	No effect	Functional	Physiology	Mouse	C57/BL6beta cR knockout	Adult	Male		Thoracic	Compression	Survival				Steel Rod	15g	Systemic	Erythropoietin	Intraperitoneal	10 _l/kg	10	10		No change	6 w					
15456912	15456912	Open PDF	Brines	Brines M, Grasso G, Fiordaliso F, Sfacteria A, Ghezzi P, Fratelli M, Latini R, Xie QW, Smart J, Su-Rick CJ, Pobre E, Diaz D, Gomez D, Hand C, Coleman T, Cerami A.	2004	PNAS	Negative	Functional	Locomotor test	Mouse	C57/BL6beta cR knockout	Adult	Male		Thoracic	Compression	BBB	Calculation of area under curve	9 [11]		Steel Rod	15g	Systemic	Erythropoietin	Intraperitoneal	10 _l/kg	10	10		Decrease	6 w			42	9	11
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	neutrophils  in lesion site			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease	1 w	>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	macrophages in lesion site			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease		>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	neutrophils  in lesion site			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease		>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	neutrophils  in lesion site			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease		>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	macrophages  in lesion site			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease	1 w	>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	neutrophils  in lesion site			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease	1 w	>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	macrophages  in lesion site			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease	1 w	>=200, <300	>=200, <300			
15465595	15465595	Open PDF	Saville	Saville LR, Pospisil CH, Mawhinney LA, Bao F, Simedrea FC, Peters AA, O'Connell PJ, Weaver LC, Dekaban GA.	2004	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Inflammatory cells	macrophages in lesion site			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	5	5		Decrease		>=200, <300	>=200, <300			
15605375	15605375	Open PDF	Pannu	Pannu R, Barbosa E, Singh AK, Singh I.	2005	J Neurosci Res	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Pro-inflammatory Cytokine	expression (mRNA) of iNOS, TNF_ and IL-1_			Weight drop	30 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease		>=200, <300	>=200, <300			
15605375	15605375	Open PDF	Pannu	Pannu R, Barbosa E, Singh AK, Singh I.	2005	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Lesion volume	secondary tissue damage			Weight drop	30 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease		>=200, <300	>=200, <300			
15605375	15605375	Open PDF	Pannu	Pannu R, Barbosa E, Singh AK, Singh I.	2005	J Neurosci Res	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Inflammatory cells	macrophage invasion			Weight drop	30 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease		>=200, <300	>=200, <300			
15605375	15605375	Open PDF	Pannu	Pannu R, Barbosa E, Singh AK, Singh I.	2005	J Neurosci Res	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Astrogliosis	GFAP reactive astrocytes			Weight drop	30 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease		>=200, <300	>=200, <300			
15605375	15605375	Open PDF	Pannu	Pannu R, Barbosa E, Singh AK, Singh I.	2005	J Neurosci Res	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	BBB		19 [9]		Weight drop	30 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	9	9		Increase	15 d	>=200, <300	>=200, <300	15	19	9
15605375	15605375	Open PDF	Pannu	Pannu R, Barbosa E, Singh AK, Singh I.	2005	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Apoptosis	TUNEL-positive apoptotic cells			Weight drop	30 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	1 w	>=200, <300	>=200, <300			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Mechanical allodynia				Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Decrease		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	BBB				Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	9	7		Increase		>=200, <300	>=300, <400	28	10,6	7,8
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Other	sparing of fibers in lateral serotonergic projections			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Increase		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Axonal regeneration	collateral sprouting in lateral serotonergic projections			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Increase		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Myelination	compact myelin			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Increase		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Axonal regeneration	axons transversing the lesion			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Increase		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Axonal regeneration	serotonergic fibres caudal in the IML			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Increase		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Axonal regeneration	serotonergic fibres caudal in the dorsal and ventral horns			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Increase		>=200, <300	>=300, <400			
15659600	15659600	Open PDF	Oatway	Oatway MA, Chen Y, Bruce JC, Dekaban GA, Weaver LC.	2005	J Neurosci	No effect	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-350 g	Thoracic	Compression	Axonal regeneration	serotonergic fibres rostral in the dorsal horn			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	19	22		Decrease		>=200, <300	>=300, <400			
15684768	15684768	Open PDF	Laverty	Laverty PH, Leskovar A, Breur GJ, Coates JR, Bergman RL, Widmer WR, Toombs JP, Shapiro S, Borgens RB.	2004	J Neurotrauma	Positive	Functional	Sensory test	Dog	Various	Adult	Not defined	40lbs	Thoracic	Compression	Pain	return of deep pain in hindlimbs and digits (indication of neurological recovery in complete paraplegia canine cases)					Systemic	Polyethylene Glycol (PEG)	Intravenous	2 ml/kg	19			Increase		>=500	>=500			
15684768	15684768	Open PDF	Laverty	Laverty PH, Leskovar A, Breur GJ, Coates JR, Bergman RL, Widmer WR, Toombs JP, Shapiro S, Borgens RB.	2004	J Neurotrauma	Positive	Functional	Electrophysiology	Dog	Various	Adult	Not defined	40lbs	Thoracic	Compression	Somatosensory evoked potentials	63% improvement in recovered nerve conduction vs 0% in 36 historical control dogs					Systemic	Polyethylene Glycol (PEG)	Intravenous	2 ml/kg	19			Increase		>=500	>=500			
15716629	15716629	Open PDF	Caggiano	Caggiano AO, Zimber MP, Ganguly A, Blight AR, Gruskin EA.	2005	J Neurotrauma	Positive	Functional	Physiology	Rat	Long-Evans	Not defined	Female		Thoracic	Compression	Urine voiding	residual volume			Forceps		Local	Chondroitinase ABC	Intrathecal	0,06 U	15	15		Decrease						
15716629	15716629	Open PDF	Caggiano	Caggiano AO, Zimber MP, Ganguly A, Blight AR, Gruskin EA.	2005	J Neurotrauma	Positive	Functional	Locomotor test	Rat	Long-Evans	Not defined	Female		Thoracic	Compression	BBB		9.1 [6.85]		Forceps		Local	Chondroitinase ABC	Intrathecal	0,06 U	15	15		Increase				70	9,1	6,85
15716629	15716629	Open PDF	Caggiano	Caggiano AO, Zimber MP, Ganguly A, Blight AR, Gruskin EA.	2005	J Neurotrauma	Positive	Functional	Locomotor test	Rat	Long-Evans	Not defined	Female		Thoracic	Compression	BBB		7.5 [3.67]		Forceps		Local	Chondroitinase ABC	Intrathecal	0,06 U	7	6		Increase				70	7,5	3,67
15716629	15716629	Open PDF	Caggiano	Caggiano AO, Zimber MP, Ganguly A, Blight AR, Gruskin EA.	2005	J Neurotrauma	No effect	Functional	Locomotor test	Rat	Long-Evans	Not defined	Female		Thoracic	Compression	BBB		9.9 [9.7]		Forceps		Local	Chondroitinase ABC	Intrathecal	0,06 U	13	14		No change				70	9,9	9,7
15748877	15748877	Open PDF	McAdoo	McAdoo DJ, Hughes MG, Nie L, Shah B, Clifton C, Fullwood S, Hulsebosch CE.	2005	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	240-320 g	Thoracic	Contusion	Toxicity	reduction of glutamate release within spinal cord (microdialysis)			Infinite Horizon Impactor	150 kdynes	Systemic	Riluzole	Microdialysis	2 mM	6	6		No change		>=200, <300	>=300, <400			
15748877	15748877	Open PDF	McAdoo	McAdoo DJ, Hughes MG, Nie L, Shah B, Clifton C, Fullwood S, Hulsebosch CE.	2005	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	240-320 g	Thoracic	Contusion	Toxicity	reduction of glutamate release within spinal cord (microdialysis)			MASCIS impactor	10 g x 25 mm	Systemic	Riluzole	Microdialysis	2 mM	6	6		No change		>=200, <300	>=300, <400			
15852057	15852057	Open PDF	Pantovic	Pantovi_ R, Dragani_ P, Erakovi_ V, Blagovi_ B, Milin C, Simoni_ A.	2005	Spinal Cord	Positive	Functional	Locomotor test	Rabbit	Not defined	Adult	Not defined	2.5-3.5 kg	Cervical	Contusion	Open field	Tarlov scale	2.7 [1.3]		Weight drop	12.5 g x 120 mm / 150 g-cm	Systemic	Indomethacin	Intravenous	0.1, 0.3, 1.0, or 3.0 mg/kg	6	6		Increase		>=500	>=500		2,7	1,3
15852057	15852057	Open PDF	Pantovic	Pantovi_ R, Dragani_ P, Erakovi_ V, Blagovi_ B, Milin C, Simoni_ A.	2005	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rabbit	Not defined	Adult	Not defined	2.5-3.5 kg	Cervical	Contusion	Oxidative stress	free fatty acids			Weight drop	12.5 g x 120 mm / 150 g-cm	Systemic	Indomethacin	Intravenous	0.1, 0.3, 1.0, or 3.0 mg/kg	6	6		Decrease		>=500	>=500			
15890340	15890340	Open PDF	Gris	Gris D, Marsh DR, Dekaban GA, Weaver LC.	2005	Exp Neurol	Positive	Functional	Physiology	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Autonomic dysreflexia	colon distension			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	21		Decrease	2 w	>=200, <300	>=200, <300			
15890340	15890340	Open PDF	Gris	Gris D, Marsh DR, Dekaban GA, Weaver LC.	2005	Exp Neurol	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Axonal regeneration	CGRP-immunoreactive fibres			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	21		Increase	2 w	>=200, <300	>=200, <300			
15890340	15890340	Open PDF	Gris	Gris D, Marsh DR, Dekaban GA, Weaver LC.	2005	Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Lesion volume				Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	21		Decrease	2 w	>=200, <300	>=200, <300			
15890340	15890340	Open PDF	Gris	Gris D, Marsh DR, Dekaban GA, Weaver LC.	2005	Exp Neurol	No effect	Functional	Physiology	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Blood circulation	resting mean arterial pressure			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	21		Increase	2 w	>=200, <300	>=200, <300			
15890340	15890340	Open PDF	Gris	Gris D, Marsh DR, Dekaban GA, Weaver LC.	2005	Exp Neurol	No effect	Functional	Physiology	Rat	Wistar	Adult	Female	250 g	Thoracic	Compression	Blood circulation	resting mean arterial pressure			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	17	21		Increase	2 w	>=200, <300	>=200, <300			
16130149	16130149	Open PDF	Sribnick	Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL.	2005	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Toxicity	NF_B expression in penumbra in nuclei			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	3	3		Decrease	2d	>=200, <300	>=300, <400			
16130149	16130149	Open PDF	Sribnick	Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL.	2005	J Neurosci Res	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Inflammatory cells	microglia and macrophage accumulation (OX42+ and ED2+ in tissue sections) in lesion and caudal penumbra			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	3	3		Decrease	2d	>=200, <300	>=300, <400			
16130149	16130149	Open PDF	Sribnick	Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL.	2005	J Neurosci Res	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Myelination	myelin in lesion and penumbra			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	3	3		Increase	2d	>=200, <300	>=300, <400			
16130149	16130149	Open PDF	Sribnick	Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL.	2005	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Cyst volume	edema in lesion (water content)			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	3	3		Decrease	2d	>=200, <300	>=300, <400			
16130149	16130149	Open PDF	Sribnick	Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL.	2005	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Toxicity	NF_B expression in penumbra in cytosol			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	3	3		Increase	2d	>=200, <300	>=300, <400			
16130149	16130149	Open PDF	Sribnick	Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL.	2005	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Toxicity	NF_B expression in lesion			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	3	3		No change	2d	>=200, <300	>=300, <400			
16240212	16240212	Open PDF	Strain	Strain GM, Waldrop RD.	2005	Dig Dis Sci	No effect	Functional	Physiology	Rat	SD	Adult	Male	300-500 g	Cervical	Complete transection	Gastric ulcerogenesis	possible reasons: decreased circulation, ulcer index	1.62 [0.25]				Systemic	Hypothermia		23,8 +/- 0,9_C	12	12	12	Increase		>=300, <400	>=500		1,62	0,25
16240212	16240212	Open PDF	Strain	Strain GM, Waldrop RD.	2005	Dig Dis Sci	No effect	Functional	Physiology	Rat	SD	Adult	Male	300-500 g	Cervical	Complete transection	Gastric ulcerogenesis	possible reasons: decreased circulation, ulcer index	2.00 [0.25]				Systemic	Hypothermia		19,4 +/- 0,7_C	12	12	12	Increase		>=300, <400	>=500		2	0,25
16256834	16256834	Open PDF	Solaroglu	Solaroglu I, Kaptanoglu E, Okutan O, Beskonakli E, Attar A, Kilinc K.	2005	Surg Neurol	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Apoptosis	caspase-3 activity			Allen Weight Drop	40 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	8	8		Decrease		>=200, <300	>=200, <300			
16259377	16259377	Open PDF	Ozdemir	Ozdemir M, Cengiz SL, G_rbilek M, O__n TC, Ust_n ME.	2005	Magnes Res	Positive	Non-functional	Secondary degeneration	Rabbit	New Zeland	Adult	Not defined		Thoracic	Contusion	Oxidative stress	malondialdehyde (MDA)			Weight drop		Systemic	Magnesium	Intravenous	100 mg/kg	10	10		Decrease	1 h					
16259377	16259377	Open PDF	Ozdemir	Ozdemir M, Cengiz SL, G_rbilek M, O__n TC, Ust_n ME.	2005	Magnes Res	Positive	Functional	Physiology	Rabbit	New Zeland	Adult	Not defined		Thoracic	Contusion	Blood circulation	heart rate			Weight drop		Systemic	Magnesium	Intravenous	100 mg/kg	10	10		Decrease						
16259377	16259377	Open PDF	Ozdemir	Ozdemir M, Cengiz SL, G_rbilek M, O__n TC, Ust_n ME.	2005	Magnes Res	Positive	Non-functional	Secondary degeneration	Rabbit	New Zeland	Adult	Not defined		Thoracic	Contusion	Oxidative stress	lactate levels			Weight drop		Systemic	Magnesium	Intravenous	100 mg/kg	10	10		Decrease	1 h					
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Lesion volume	increased spared tissue at and around injury epicenter			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	18	18		Decrease		>=200, <300	>=200, <300			
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Lesion volume	5000 IU/kg increased spared tissue at and around injury epicenter			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	100, 500 or 5000 IU/kg	18	18		Decrease		>=200, <300	>=200, <300			
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	BBB				Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	18	18		Increase	4 w	>=200, <300	>=200, <300	28	13,5	9
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Non-functional	Inflammation	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Pro-inflammatory Cytokine	cytokines MIP-2, TNF-_, IL-1_ and IL-6			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	18	18		Decrease		>=200, <300	>=200, <300			
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Non-functional	Inflammation	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Pro-inflammatory Cytokine	cytokines MIP-2, TNF-_, IL-1_ and IL-6			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intravenous	100, 500 or 5000 IU/kg	18	18		Decrease		>=200, <300	>=200, <300			
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Non-functional	Inflammation	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Pro-inflammatory Cytokine	cytokines MIP-2, TNF-_, IL-1_ and IL-6			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	100, 500 or 5000 IU/kg	18	18		Decrease		>=200, <300	>=200, <300			
16260722	16260722	Open PDF	Gorio	Gorio A, Madaschi L, Di Stefano B, Carelli S, Di Giulio AM, De Biasi S, Coleman T, Cerami A, Brines M.	2005	PNAS	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	BBB				Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intravenous	500 IU/kg	18	18		Increase	4 w	>=200, <300	>=200, <300	28	13,5	9
16317421	16317421	Open PDF	Liu	Liu F, You SW, Yao LP, Liu HL, Jiao XY, Shi M, Zhao QB, Ju G.	2006	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-220 g	Thoracic	Compression	Lesion volume	degenerative areas in the spinal cord (H&E stain)			Clip	95 g	Systemic	Inosine	Intraperitoneal	75 mg/kg	6	6		Decrease	3 d	>=200, <300	>=200, <300			
16317421	16317421	Open PDF	Liu	Liu F, You SW, Yao LP, Liu HL, Jiao XY, Shi M, Zhao QB, Ju G.	2006	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-220 g	Thoracic	Compression	Apoptosis	TUNEL			Clip	95 g	Systemic	Inosine	Intraperitoneal	75 mg/kg	6	6		Decrease	3 d	>=200, <300	>=200, <300			
16317421	16317421	Open PDF	Liu	Liu F, You SW, Yao LP, Liu HL, Jiao XY, Shi M, Zhao QB, Ju G.	2006	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-220 g	Thoracic	Compression	Apoptosis	TUNEL			Clip	95 g	Systemic	Inosine	Intraperitoneal	75 mg/kg	6	6		Decrease	3 d	>=200, <300	>=200, <300			
16317421	16317421	Open PDF	Liu	Liu F, You SW, Yao LP, Liu HL, Jiao XY, Shi M, Zhao QB, Ju G.	2006	Spinal Cord	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	200-220 g	Thoracic	Compression	Lesion volume	degenerative areas in the spinal cord (H&E stain)			Clip	95 g	Systemic	Inosine	Intraperitoneal	75 mg/kg	6	6		Decrease	3 d	>=200, <300	>=200, <300			
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Myelination	myelin staining			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	13	20		Increase	2 w	>=200, <300	>=300, <400			
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Myelination	myelin close to lesion center			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	6		Increase	6 w	>=200, <300	>=300, <400			
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Axonal regeneration	neurofilament adjacent to lesion center			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	7	7		Increase	12 w	>=200, <300	>=300, <400			
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Axonal regeneration	neurofilament adjacent to lesion center			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	6		Increase	6 w	>=200, <300	>=300, <400			
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Myelination	myelin close to lesion center			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	7	7		Increase	12 w	>=200, <300	>=300, <400			
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	BBB	only in combination with MP			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	6		increase	6 w	>=200, <300	>=300, <400	42	8,4	7,4
16379576	16379576	Open PDF	Weaver	Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.	2005	J Neurotrauma	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	BBB	only in combination with MP			Clip	35 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	7	7		increase	12 w	>=200, <300	>=300, <400	84	10	8
16396987	16396987	Open PDF	Labombarda	Labombarda F, Pianos A, Liere P, Eychenne B, Gonzalez S, Cambourg A, De Nicola AF, Schumacher M, Guennoun R.	2006	Endocrinology	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	neurotrophic factors	5_hydroprogesterone and 3_5_-tetrahydroprogesterone in spinal cord					Systemic	Progesterone	Subcutaneous	4 mg/kg	6	11		Increase	75 h	>=200, <300	>=300, <400			
16396987	16396987	Open PDF	Labombarda	Labombarda F, Pianos A, Liere P, Eychenne B, Gonzalez S, Cambourg A, De Nicola AF, Schumacher M, Guennoun R.	2006	Endocrinology	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	neurotrophic factors	3_5_-tetrahydroprogesterone in spinal cord					Systemic	Progesterone	Subcutaneous	4 mg/kg	6	11		Increase	75 h	>=200, <300	>=300, <400			
16477096	16477096		Boran	Boran BO, Colak A, Kutlay M.	2005	Restor Neurol Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	180-220 g	Thoracic	Contusion	Swimming test	motor recovery			Weight drop	50 g x cm	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	20	20		Increase	2 w	>=100, <200	>=200, <300			
16503802	16503802	Open PDF	Labombarda	Labombarda F, Gonzalez S, Gonzalez Deniselle MC, Garay L, Guennoun R, Schumacher M, De Nicola AF.	2006	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Myelination	myelin basic protein (MBP) in corticospinal tract and dorsal ascending tract (and in ventral funiculus?)					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	Increase	75 h	>=200, <300	>=300, <400			
16503802	16503802	Open PDF	Labombarda	Labombarda F, Gonzalez S, Gonzalez Deniselle MC, Garay L, Guennoun R, Schumacher M, De Nicola AF.	2006	J Neurotrauma	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Oligodendroglia	mature oligos (RIP)					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	No change	75 h	>=200, <300	>=300, <400			
16503802	16503802	Open PDF	Labombarda	Labombarda F, Gonzalez S, Gonzalez Deniselle MC, Garay L, Guennoun R, Schumacher M, De Nicola AF.	2006	J Neurotrauma	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Oligodendroglia	number of NG2 immunoreactive cells (oligodendrocyte precursors) in grey and white matter					Systemic	Progesterone	Subcutaneous	4 mg/kg	4	4	4	Increase	75 h	>=200, <300	>=300, <400			
16547753	16547753	Open PDF	Cetin	Cetin A, Nas K, B_y_kbayram H, Ceviz A, Olmez G.	2006	Eur Spine J	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	200-300 g	Thoracic	Compression	Swimming test	behavioral recovery			Aneurysm Clip	0.6 N	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	8	8		Increase		>=200, <300	>=300, <400			
16547753	16547753	Open PDF	Cetin	Cetin A, Nas K, B_y_kbayram H, Ceviz A, Olmez G.	2006	Eur Spine J	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	200-300 g	Thoracic	Compression	Lesion volume	tissue preservation increased			Aneurysm Clip	0.6 N	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	8	8		Decrease		>=200, <300	>=300, <400			
16619678	16619678	Open PDF	Grasso	Grasso G, Sfacteria A, Erbayraktar S, Passalacqua M, Meli F, Gokmen N, Yilmaz O, La Torre D, Buemi M, Iacopino DG, Coleman T, Cerami A, Brines M, Tomasello F.	2006	J Neurosurg Spine	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	275-300 g	Thoracic	Compression	BBB		13 [9]		Clip	58 g	Systemic	Erythropoietin	Intravenous	10 _g/kg	6	6		Increase	6 w	>=200, <300	>=300, <400	42	13	9
16619678	16619678	Open PDF	Grasso	Grasso G, Sfacteria A, Erbayraktar S, Passalacqua M, Meli F, Gokmen N, Yilmaz O, La Torre D, Buemi M, Iacopino DG, Coleman T, Cerami A, Brines M, Tomasello F.	2006	J Neurosurg Spine	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	275-300 g	Thoracic	Compression	BBB		16 [9]		Clip	58 g	Systemic	Erythropoietin	Intravenous	10 _g/kg	6	6		Increase	6 w	>=200, <300	>=300, <400	42	16	9
16624960	16624960	Open PDF	Massey	Massey JM, Hubscher CH, Wagoner MR, Decker JA, Amps J, Silver J, Onifer SM.	2006	J Neurosci	Positive	Functional	Electrophysiology	Rat	SD	Adult	Male	250-300 g	Cervical	Partial transection	Somatosensory evoked potentials	microelectrode recording from cuneate nucleus: significantly more sites responding to forelimb stimulation,p < 0,001; control: 46,3% +/- 3,3; ChABC: 74,5% +/- 4,8		Quadsection			Local	Chondroitinase ABC	Intraspinal injection	1 _l at  50 U/ml = 0,05 U	6	5		Increase		>=200, <300	>=300, <400			
16624960	16624960	Open PDF	Massey	Massey JM, Hubscher CH, Wagoner MR, Decker JA, Amps J, Silver J, Onifer SM.	2006	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	250-300 g	Cervical	Partial transection	Axonal regeneration	CTB-labeled sensory fibers in the brainstem,p < 0,01; control: 165,41 +/- 67,73; ChABC: 323,73 +/- 69,53		Quadsection			Local	Chondroitinase ABC	Intraspinal injection	1 _l at  50 U/ml = 0,05 U	6	5		Increase		>=200, <300	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	4	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	4	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Inflammation				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	4	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Inflammation				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Inflammation				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	BBB	point difference			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Increase	4 w	>=300, <400	>=300, <400	28	15	8,3
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	BBB	point difference			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Increase	4 w	>=300, <400	>=300, <400	28	14,5	8,3
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Inflammation				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	BBB	point difference			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	4	3		Increase	4 w	>=300, <400	>=300, <400	28	14,6	8,3
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Decrease		>=300, <400	>=300, <400			
16638021	16638021	Open PDF	Festoff	Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.	2006	J Neurochem	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	300-325 g	Thoracic	Contusion	BBB	point difference			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg	12	3		Increase	4 w	>=300, <400	>=300, <400	28	14,5	8,3
16672645	16672645	Open PDF	Tan	Tan AM, Colletti M, Rorai AT, Skene JH, Levine JM.	2006	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	175-200 g	Thoracic	Partial transection	Axonal regeneration	labeled axons penetrated the caudal border of the lesion and grew into and beyond the lesion center		Dorsal bilateral, extended ventrally to the depth of the central canal (~1,5 mm)			Local	Anti-NG2 Antibody	Gelfoam	50 _l	7	3		Increase		>=100, <200	>=200, <300			
16705682	16705682	Open PDF	Kim	Kim BG, Dai HN, Lynskey JV, McAtee M, Bregman BS.	2006	J Comp Neurol	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Cervical	Partial transection	Axonal regeneration	5-HT staining in the ventral grey matter distal (C6/7) to the injury site [%]	26.3 [21.7]	Hemisection			Local	Chondroitinase ABC	Gelfoam	0,2 U	7	7		No change		>=200, <300	>=200, <300		26,3	21,7
16705682	16705682	Open PDF	Kim	Kim BG, Dai HN, Lynskey JV, McAtee M, Bregman BS.	2006	J Comp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Cervical	Partial transection	Rearing test	Rearing cylinder test		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,2 U	7	7		No change		>=200, <300	>=200, <300			
16705682	16705682	Open PDF	Kim	Kim BG, Dai HN, Lynskey JV, McAtee M, Bregman BS.	2006	J Comp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Cervical	Partial transection	Walking analysis	gridwalk		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,2 U	7	7		No change		>=200, <300	>=200, <300			
16705682	16705682	Open PDF	Kim	Kim BG, Dai HN, Lynskey JV, McAtee M, Bregman BS.	2006	J Comp Neurol	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Cervical	Partial transection	Axonal regeneration	anterograde CST tracing		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,2 U	7	7		No change		>=200, <300	>=200, <300			
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	Positive	Functional	Physiology	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Autonomic dysreflexia						Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		Increase						
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	Positive	Functional	Physiology	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Blood circulation	blood pressure increases [mmHg]	 9 [25]				Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		Decrease					9	25
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	No effect	Non-functional	Inflammation	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Inflammatory cells	CD11b immunoreactivity for microglia and macrophages					Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		No change	3 w					
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	No effect	Non-functional	Secondary degeneration	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Lesion volume	fibrous scar in the injured cord					Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		No change	3 w					
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	No effect	Non-functional	Neuronal regeneration	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Axonal regeneration	size of CGRP-immunoreactive primary afferent arbour					Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		No change	3 w					
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	No effect	Functional	Reflex	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Tail pinch reflex						Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		No change						
16712973	16712973	Open PDF	Webb	Webb AA, Chan CB, Brown A, Saleh TM.	2006	Behav Brain Res	Negative	Non-functional	Inflammation	Mouse	B6.129	Adult	Male		Thoracic	Complete transection	Inflammation	serum concentrations (fold difference)	3 [1]				Systemic	Estrogen	Subcutaneous	0,5 mg	4	4		Increase	3 w				3	1
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Compression	Body weight	body weight gains after SCI		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Compression	Lesion volume	white matter sparing		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Aged	Female	350-400 g	Thoracic	Crush	BBB				Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Increase		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Physiology	Rat	SD	Aged	Female	350-400 g	Thoracic	Compression	Body weight	body weight gains after SCI		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Aged	Female	350-400 g	Thoracic	Compression	Apoptosis	apoptotic neurons (TUNEL)		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Aged	Female	350-400 g	Thoracic	Compression	Cell loss	increase of number of ventral horn neurons (Nissl)		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Aged	Female	350-400 g	Thoracic	Compression	Lesion volume	white matter sparing		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Aged	Female	350-400 g	Thoracic	Compression	BBB			Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Increase		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Physiology	Rat	SD	Aged	Female	350-400 g	Thoracic	Crush	Body weight	body weight gains after SCI			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Crush	BBB				Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Increase		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Compression	BBB			Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Increase		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Aged	Female	350-400 g	Thoracic	Crush	Lesion volume	white matter sparing			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Compression	Apoptosis	apoptotic neurons (TUNEL)		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Crush	Body weight	body weight gains after SCI			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Crush	Apoptosis	apoptotic neurons (TUNEL)			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	200-250 g	Thoracic	Crush	Cell loss	increase of number of ventral horn neurons (Nissl)			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Crush	Lesion volume	white matter sparing			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	200-250 g	Thoracic	Compression	Cell loss	increase of number of ventral horn neurons (Nissl)		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Aged	Female	350-400 g	Thoracic	Crush	Apoptosis	apoptotic neurons (TUNEL)			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Aged	Female	350-400 g	Thoracic	Crush	Cell loss	increase of number of ventral horn neurons (Nissl)			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		Decrease	3 w	>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	No effect	Functional	Physiology	Rat	SD	Aged	Female	350-400 g	Thoracic	Crush	Urine voiding	fluorojade, urine voiding			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		No change		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	No effect	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Crush	Urine voiding	fluorojade, urine voiding			Forceps		Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		No change		>=200, <300	>=200, <300			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	No effect	Functional	Physiology	Rat	SD	Aged	Female	350-400 g	Thoracic	Compression	Urine voiding	fluorojade, urine voiding		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		No change		>=300, <400	>=400, <500			
16774470	16774470	Open PDF	Chaovipoch	Chaovipoch P, Jelks KA, Gerhold LM, West EJ, Chongthammakun S, Floyd CL.	2006	J Neurotrauma	No effect	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Compression	Urine voiding	fluorojade, urine voiding		Lateral		0.5 mm	Systemic	Estrogen	Subcutaneous	180 g/ml in capsules 	n/a	n/a		No change		>=200, <300	>=200, <300			
16837588	16837588	Open PDF	Houle	Houle JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J.	2006	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	225-250 g	Cervical	Partial transection	Axonal regeneration	rubrospinal anterograde tracing, mean length of axons entering spinal cord from PNG [_m]	1271.6 [11.5]	Hemisection			Local	Chondroitinase ABC		0,005 U	7	5		Increase		>=200, <300	>=200, <300		1271,6	11,5
16837588	16837588	Open PDF	Houle	Houle JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J.	2006	J Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	225-250 g	Cervical	Partial transection	Open field	Grooming task	2.86 [1.6]	Hemisection			Local	Chondroitinase ABC		0,005 U	7	5		Increase		>=200, <300	>=200, <300		2,86	1,6
16837588	16837588	Open PDF	Houle	Houle JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J.	2006	J Neurosci	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	225-250 g	Cervical	Partial transection	Rearing test	Rearing cylinder test		Hemisection			Local	Chondroitinase ABC		0,005 U	7	5		No change		>=200, <300	>=200, <300			
16837588	16837588	Open PDF	Houle	Houle JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J.	2006	J Neurosci	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	225-250 g	Cervical	Partial transection	Walking analysis	rope ladder		Hemisection			Local	Chondroitinase ABC		0,005 U	7	5		No change		>=200, <300	>=200, <300			
16902996	16902996	Open PDF	Sribnick	Sribnick EA, Matzelle DD, Ray SK, Banik NL.	2006	J Neurosci Res	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Axonal regeneration	neurofilament in lesion			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	4	4		No change	2d	>=200, <300	>=300, <400			
16902996	16902996	Open PDF	Sribnick	Sribnick EA, Matzelle DD, Ray SK, Banik NL.	2006	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	calpain (expression and activity) in lesion			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	4	4		No change	2d	>=200, <300	>=300, <400			
16902996	16902996	Open PDF	Sribnick	Sribnick EA, Matzelle DD, Ray SK, Banik NL.	2006	J Neurosci Res	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Receptor expression	estrogen receptor _ 			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	4	4		Decrease	2d	>=200, <300	>=300, <400			
16902996	16902996	Open PDF	Sribnick	Sribnick EA, Matzelle DD, Ray SK, Banik NL.	2006	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis	percent cytosolic cytochrome c in lesion			NYU Weight Drop	5 g x 8 cm	Systemic	Estrogen	Intravenous	4 mg/kg	4	4		No change	2d	>=200, <300	>=300, <400			
16965762	16965762	Open PDF	Huang	Huang WC, Kuo WC, Cherng JH, Hsu SH, Chen PR, Huang SH, Huang MC, Liu JC, Cheng H.	2006	Biochem Biophys Res Commun	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	250-300 g	Thoracic	Complete transection	BBB		6 [2.7]				Local	Chondroitinase ABC	Intraspinal injection	6 _l at 1 U/ml = 0,006 U	4	4		Increase		>=200, <300	>=300, <400	56	6	2,7
16965762	16965762	Open PDF	Huang	Huang WC, Kuo WC, Cherng JH, Hsu SH, Chen PR, Huang SH, Huang MC, Liu JC, Cheng H.	2006	Biochem Biophys Res Commun	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Complete transection	Axonal regeneration	anterograde CST tracing: growth across lesion site					Local	Chondroitinase ABC	Intraspinal injection	6 _l at 1 U/ml = 0,006 U	4	4		Increase		>=200, <300	>=300, <400			
16965762	16965762	Open PDF	Huang	Huang WC, Kuo WC, Cherng JH, Hsu SH, Chen PR, Huang SH, Huang MC, Liu JC, Cheng H.	2006	Biochem Biophys Res Commun	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Complete transection	Cyst volume	large cysts					Local	Chondroitinase ABC	Intraspinal injection	6 _l at  5 U/ml = 0,03 U	4	4		Increase		>=200, <300	>=300, <400			
16965762	16965762	Open PDF	Huang	Huang WC, Kuo WC, Cherng JH, Hsu SH, Chen PR, Huang SH, Huang MC, Liu JC, Cheng H.	2006	Biochem Biophys Res Commun	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	250-300 g	Thoracic	Complete transection	BBB						Local	Chondroitinase ABC	Intraspinal injection	6 _l at  5 U/ml = 0,03 U	4	4		No change		>=200, <300	>=300, <400	56	0,7	2,7
17023852	17023852	Open PDF	Arishima	Arishima Y, Setoguchi T, Yamaura I, Yone K, Komiya S.	2006	Spine	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	380-500 g	Thoracic	Compression	Apoptosis	oligodendrocytes and motor neurons; TUNEL or caspase3 staining			Weight drop	120 g	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	4	4		Decrease	1 w	>=300, <400	>=500			
17023852	17023852	Open PDF	Arishima	Arishima Y, Setoguchi T, Yamaura I, Yone K, Komiya S.	2006	Spine	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	380-500 g	Thoracic	Compression	Lesion volume	cavitation volume at injury epicenter, H&E stain			Weight drop	120 g	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	4	4		Decrease		>=300, <400	>=500			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Oxidative stress	protein oxidation, DNP			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	4		Decrease	72 h	>=200, <300	>=300, <400			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Oxidative stress	lipid peroxidation, HNE measurement			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	4		Decrease	72 h	>=200, <300	>=300, <400			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Inflammatory cells	ED-1 expression in intraspinal neutrophils and macrophages			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	4		Decrease	72 h	>=200, <300	>=300, <400			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Oxidative stress	protein nitration, nitrotyrosine content			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	4		Decrease	72 h	>=200, <300	>=300, <400			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	BBB				Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	5		Increase	5 w	>=200, <300	>=300, <400	35	8,9	7,7
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Oxidative stress	DNA oxidation, APE/Ref-1 protein expression			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	4		Decrease	72 h	>=200, <300	>=300, <400			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Functional	Physiology	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Autonomic dysreflexia	mean arterial blood pressure after colon distension			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	4	5		Decrease	5 w	>=200, <300	>=300, <400			
17048772	17048772	Open PDF	Ditor	Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC.	2006	J Neurosurg Spine	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Inflammatory cells	MPO activity in intraspinal neutrophils and macrophages			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	6	5		Decrease	72 h	>=200, <300	>=300, <400			
17050723	17050723	Open PDF	Barritt	Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB, Bradbury EJ.	2006	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	220-250 g	Cervical	Crush	Axonal regeneration	5-HT sprouting caudal to the injury in the ventral horn 		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	16	16	16	Increase		>=200, <300	>=200, <300			
17050723	17050723	Open PDF	Barritt	Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB, Bradbury EJ.	2006	J Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	220-250 g	Cervical	Crush	Axonal regeneration	anterograde CST tracing: sprouting proximal to the lesion site and distal to injury site at C5, but not C6		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	16	16	16	Increase		>=200, <300	>=200, <300			
17050723	17050723	Open PDF	Barritt	Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB, Bradbury EJ.	2006	J Neurosci	No effect	Functional	Sensory test	Rat	Wistar	Adult	Male	220-250 g	Cervical	Crush	Thermal hyperalgesia	thermal stimuli		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	16	16	16	No change		>=200, <300	>=200, <300			
17050723	17050723	Open PDF	Barritt	Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB, Bradbury EJ.	2006	J Neurosci	No effect	Functional	Sensory test	Rat	Wistar	Adult	Male	220-250 g	Cervical	Crush	Mechanical allodynia	mechanical stimuli		Dorsal column			Local	Chondroitinase ABC	Intrathecal	6 _l at 10 U/ml = 0,06 U	16	16	16	No change		>=200, <300	>=200, <300			
17141961	17141961	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Gorio A, De Biasi S.	2007	Neuroscience	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Lesion volume	ventral white matter			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	7	7		Increase	4 w	>=200, <300	>=200, <300			
17141961	17141961	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Gorio A, De Biasi S.	2007	Neuroscience	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Axonal regeneration	5-HT immunoreactivity			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	7	7		Increase	4 w	>=200, <300	>=200, <300			
17141961	17141961	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Gorio A, De Biasi S.	2007	Neuroscience	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Growth inhibitor expression	phosphacan immunoreactivity			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	7	7		Decrease	4 w	>=200, <300	>=200, <300			
17141961	17141961	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Gorio A, De Biasi S.	2007	Neuroscience	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	BBB		15 [8]		Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	7	7		Increase	4 w	>=200, <300	>=200, <300	28	15	8
17141961	17141961	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Gorio A, De Biasi S.	2007	Neuroscience	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Oligodendroglia	NG2 expressing OPCs in the cord			Univ of Trieste Impactor	Modified	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	7	7		Increase	4 w	>=200, <300	>=200, <300			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Astrogliosis	decreased astrogliosis			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	6	6		Decrease		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Functional	Sensory test	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Thermal hyperalgesia				NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	6	6		Decrease	4 w	>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Inflammation	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Inflammatory cells	microglial activation			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	6	6		Decrease		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Oxidative stress	induction of anti-oxidant enzymes			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	4	4		Decrease		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	9	9		Increase		>=300, <400	>=300, <400	28	13	10
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Other	decrease of myelin loss			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	9	9		Increase		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Inflammation	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Inflammation	induction of inflammatory gene expression			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	4	4		Decrease		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	9	9		Decrease		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Cell loss	decrease of motor neuron loss			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	9	9		Decrease		>=300, <400	>=300, <400			
17167171	17167171	Open PDF	Park	Park SW, Yi JH, Miranpuri G, Satriotomo I, Bowen K, Resnick DK, Vemuganti R.	2007	J Pharmacol Exp Ther	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Not defined	300-325 g	Thoracic	Contusion	Oxidative stress	induction of inflammatory mediator protein expression			NYU impactor	10 g x 12.5 mm	Systemic	Pioglitazone	Intraperitoneal	0,5, 1,5 or 3 mg/kg	4	4		Decrease		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Open field					20 g	Systemic	Iloprost	Intraperitoneal	100 ng/kg/min	10	10		Increase		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Pro-inflammatory Cytokine	TNF expression in spinal cord				20 g	Systemic	Iloprost	Intraperitoneal	100 ng/kg/min	6	6		Decrease		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Prostaglandins	better COX inhibition				20 g	Systemic	Indomethacin	Subcutaneous	5, 10 and 20 mg/kg	6	6		Decrease		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Inflammatory cells	MPO activity				20 g	Systemic	Iloprost	Intraperitoneal	100 ng/kg/min	6	6		Decrease		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Pro-inflammatory Cytokine	prostacyclin thromboxane metabolites				20 g	Systemic	Indomethacin	Subcutaneous	5, 10 and 20 mg/kg	6	6		Decrease		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Inflammatory cells	MPO activity				20 g	Systemic	Indomethacin	Subcutaneous	5, 10 and 20 mg/kg	6	6		Increase		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Inclined plane test					20 g	Systemic	Indomethacin	Subcutaneous	5, 10 and 20 mg/kg	10	10		Decrease	8 w	>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Pro-inflammatory Cytokine	prostacyclin thromboxane metabolites				20 g	Systemic	Iloprost	Intraperitoneal	100 ng/kg/min	6	6		Increase		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Footprint analysis					20 g	Systemic	Indomethacin	Subcutaneous	5, 10 and 20 mg/kg	10	10		Decrease	8 w	>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Prostaglandins	worse COX inhibition				20 g	Systemic	Iloprost	Intraperitoneal	100 ng/kg/min	6	6		Increase		>=300, <400	>=300, <400			
17184185	17184185		Harada	Harada N, Taoka Y, Okajima K.	2006	J Neurotrauma	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	300-350 g	Thoracic	Compression	Pro-inflammatory Cytokine	TNF expression in spinal cord				20 g	Systemic	Indomethacin	Subcutaneous	5, 10 and 20 mg/kg	6	6		Increase		>=300, <400	>=300, <400			
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	Lesion volume	injury length			IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	4 mg/kg	19	19		No change		>=100, <200	>=300, <400			
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	Lesion volume	sparing of white or grey matter			IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	8 mg/kg or 16 mg/kg	18	18		No change		>=100, <200	>=300, <400			
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	Lesion volume	injury length			IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	8 mg/kg	19	19		No change		>=100, <200	>=300, <400			
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Functional	Locomotor test	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	BBB				IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	4 mg/kg	19	19		No change		>=100, <200	>=300, <400	21	11	11
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	Lesion volume	sparing of white or grey matter			IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	4 mg/kg	19	19		No change		>=100, <200	>=300, <400			
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	Lesion volume	injury length			IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	8 mg/kg or 16 mg/kg	18	18		No change		>=100, <200	>=300, <400			
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Functional	Locomotor test	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	BBB				IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	8 mg/kg or 16 mg/kg	18	18		No change		>=100, <200	>=300, <400	21	11	11
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Functional	Locomotor test	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	BBB				IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	8 mg/kg	19	19		No change		>=100, <200	>=300, <400	21	11	11
17204255	17204255	Open PDF	Fee	Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW.	2007	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-300 g	Thoracic	Contusion	Lesion volume	sparing of white or grey matter			IH Impactor	150 kdynes	Systemic	Progesterone	Intraperitoneal	8 mg/kg	19	19		No change		>=100, <200	>=300, <400			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Lesion volume	tissue sparing (H&E stain)			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	1 d	>=200, <300	>=200, <300			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Toxicity	MMP9 activity and expression			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	1 d	>=200, <300	>=200, <300			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Functional	Physiology	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Blood brain barrier	Evans Blue extravasation			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	1 d	>=200, <300	>=200, <300			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	BBB		19 [8]		Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	6	6		Increase	6 w	>=200, <300	>=200, <300	42	19	8
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	RhoA activation	Rho activity			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Increase	6 h	>=200, <300	>=200, <300			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Pro-inflammatory Cytokine	expression (mRNA) of iNOS, TNF_ and IL-1_			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	4 h	>=200, <300	>=200, <300			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	Positive	Non-functional	Inflammation	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Inflammatory cells	neutrophil and macrophage infiltration			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	1 d	>=200, <300	>=200, <300			
17217414	17217414	Open PDF	Pannu	Pannu R, Christie DK, Barbosa E, Singh I, Singh AK.	2007	J Neurochem	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Astrogliosis	GFAP expression (mRNA)			Weight drop	40 g x cm	Systemic	Atorvastatin (AT)	Oral	5 mg/kg/day	3	3		Decrease	5 d	>=200, <300	>=200, <300			
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Inflammatory cells	MPO activity			Weight drop	40 g x cm	Systemic	Human serum albumin	Intraperitoneal	1000 IU/kg	8	8		Decrease	1 d	>=200, <300	>=200, <300			
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	BBB		8 [3]		Weight drop	40 g x cm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	8	8		Increase	1 d	>=200, <300	>=200, <300	1	8	3
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Apoptosis	caspase3 activity			Weight drop	40 g x cm	Systemic	Methylprednisolone (MP)	Intraperitoneal	1000 IU/kg	8	8		Decrease	1 d	>=200, <300	>=200, <300			
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	BBB				Weight drop	40 g x cm	Systemic	Methylprednisolone (MP)	Intraperitoneal	1000 IU/kg	8	8		Increase	1 d	>=200, <300	>=200, <300	1		
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Inflammatory cells	MPO activity			Weight drop	40 g x cm	Systemic	Methylprednisolone (MP)	Intraperitoneal	1000 IU/kg	8	8		Decrease	1 d	>=200, <300	>=200, <300			
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Apoptosis	caspase3 activity			Weight drop	40 g x cm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	8	8		Decrease	1 d	>=200, <300	>=200, <300			
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Inflammatory cells	MPO activity			Weight drop	40 g x cm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	8	8		Decrease	1 d	>=200, <300	>=200, <300			
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	BBB				Weight drop	40 g x cm	Systemic	Human serum albumin	Intraperitoneal	1000 IU/kg	8	8		Increase	1 d	>=200, <300	>=200, <300	1		
17236773	17236773	Open PDF	Okutan	Okutan O, Solaroglu I, Beskonakli E, Taskin Y.	2007	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Apoptosis	caspase3 activity			Weight drop	40 g x cm	Systemic	Human serum albumin	Intraperitoneal	1000 IU/kg	8	8		Decrease	1 d	>=200, <300	>=200, <300			
17402853	17402853	Open PDF	Swartz	Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, Wilson ME, Scheff SW.	2007	J_Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Male and female	192-330 g	Thoracic	Contusion	BBB		11 [8]		IH Impactor	150 kdynes	Systemic	Estrogen	Subcutaneous	25 pg/ml or 75 pg/ml, capsules replaced at 7d for 21d	6	6		Increase	1 w	>=100, <200	>=300, <400	7	11	8
17402853	17402853	Open PDF	Swartz	Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, Wilson ME, Scheff SW.	2007	J_Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-330 g	Thoracic	Contusion	Lesion volume	epicenter sparing			IH Impactor	150 kdynes	Systemic	Estrogen	Subcutaneous	25 pg/ml or 75 pg/ml, capsules replaced at 7d for 21d	6	6		No change	3 w	>=100, <200	>=300, <400			
17402853	17402853	Open PDF	Swartz	Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, Wilson ME, Scheff SW.	2007	J_Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-330 g	Thoracic	Contusion	Lesion volume	total tissue sparing			IH Impactor	150 kdynes	Systemic	Estrogen	Subcutaneous	25 pg/ml or 75 pg/ml, capsules replaced at 7d for 21d	6	6		No change	3 w	>=100, <200	>=300, <400			
17402853	17402853	Open PDF	Swartz	Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, Wilson ME, Scheff SW.	2007	J_Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male and female	192-330 g	Thoracic	Contusion	Lesion volume	lesion length			IH Impactor	150 kdynes	Systemic	Estrogen	Subcutaneous	25 pg/ml or 75 pg/ml, capsules replaced at 7d for 21d	6	6		No change	3 w	>=100, <200	>=300, <400			
17406376	17406376	Open PDF	Conta	Conta AC, Stelzner DJ.	2008	Spinal Cord	Positive	Non-functional	Inflammation	Rat	Long-Evans	Adult	Female		Thoracic	Contusion	Inflammatory cells	volume fraction of ED1 positive profiles around lesion site			NYU impactor	10 g x 25 mm	Systemic	Inosine	Subcutaneous	100 mg/kg	8	8		Decrease	6 w					
17406376	17406376	Open PDF	Conta	Conta AC, Stelzner DJ.	2008	Spinal Cord	No effect	Non-functional	Inflammation	Rat	Long-Evans	Adult	Female		Thoracic	Contusion	Inflammatory cells	volume fraction of ED1 positive profiles around lesion site			NYU impactor	10 g x 25 mm	Systemic	Inosine	Intraperitoneal	100 mg/kg	10	10		No change	6 w					
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Lesion volume				Extradural Clip	50 g	Systemic	Magnesium			6	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Mechanical allodynia				Extradural Clip	50 g	Systemic	Magnesium			6	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Lesion volume	dorsal compact myelin sparing (solochrome cyanin staining)			Extradural Clip	50 g	Systemic	Magnesium	Intravenous	300 mg/kg	5	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	BBB		7.3 [6.4]		Extradural Clip	50 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	11	10		Increase	6 w	>=200, <300	>=200, <300	42	7,3	6,4
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Mechanical allodynia				Extradural Clip	50 g	Systemic	Magnesium	Intravenous	1 g/kg	11	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	BBB		7.6 [6,4]		Extradural Clip	50 g	Systemic	Magnesium			6	10		Increase	6 w	>=200, <300	>=200, <300	42	7,6	6,4
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Mechanical allodynia				Extradural Clip	50 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	11	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	BBB		7.7 [6.4]		Extradural Clip	50 g	Systemic	Magnesium	Intravenous	300 mg/kg	5	10		Increase	6 w	>=200, <300	>=200, <300	42	7,7	6,4
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Lesion volume	dorsal compact myelin sparing (solochrome cyanin staining)			Extradural Clip	50 g	Systemic	Magnesium			6	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Mechanical allodynia				Extradural Clip	50 g	Systemic	Magnesium	Intravenous	300 mg/kg	5	10		Decrease		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Functional	Physiology	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Autonomic dysreflexia	attenuation of increase of mean arterial pressure triggered by colonic distention (a measure of autonomic dysreflexia)			Extradural Clip	50 g	Systemic	Magnesium			6	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Functional	Physiology	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Autonomic dysreflexia	attenuation of increase of mean arterial pressure triggered by colonic distention (a measure of autonomic dysreflexia)			Extradural Clip	50 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	11	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Lesion volume				Extradural Clip	50 g	Systemic	Magnesium	Intravenous	1 g/kg	11	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Functional	Physiology	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Autonomic dysreflexia	attenuation of increase of mean arterial pressure triggered by colonic distention (a measure of autonomic dysreflexia)			Extradural Clip	50 g	Systemic	Magnesium	Intravenous	300 mg/kg	5	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Myelination	dorsal compact myelin sparing (solochrome cyanin staining)			Extradural Clip	50 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	11	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Lesion volume				Extradural Clip	50 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	11	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Functional	Physiology	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Autonomic dysreflexia	attenuation of increase of mean arterial pressure triggered by colonic distention (a measure of autonomic dysreflexia)			Extradural Clip	50 g	Systemic	Magnesium	Intravenous	1 g/kg	11	10		No change		>=200, <300	>=200, <300			
17410603	17410603	Open PDF	Ditor	Ditor DS, John SM, Roy J, Marx JC, Kittmer C, Weaver LC.	2007	J Neurosci Res	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Compression	Lesion volume	dorsal compact myelin sparing (solochrome cyanin staining)			Extradural Clip	50 g	Systemic	Magnesium	Intravenous	1 g/kg	11	10		No change		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	earlier stepping			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Lesion volume	spared white matter			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Cell loss	decrease of loss of motor neurons			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Footprint analysis	parallel paw position			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Cell loss	decrease of loss of motor neurons			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	toe clearance			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	coordination			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Cell loss	decrease of loss of motor neurons			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	coordination			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	toe clearance			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	earlier stepping			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Cell loss	decrease of loss of motor neurons			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Footprint analysis	parallel paw position			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	toe clearance			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Lesion volume	rostral to epicenter			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Open field				OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Footprint analysis	parallel paw position			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	coordination			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	earlier stepping			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Lesion volume	rostral to epicenter			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Open field	subscores			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Footprint analysis	parallel paw position			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	earlier stepping			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Walking analysis	toe clearance			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Lesion volume	spared white matter			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		Increase		>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Non-functional	Inflammation	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Inflammatory cells	macrophage density			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	7	7		No change	1 w	>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	BBB				OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		No change	5 w	>=200, <300	>=200, <300	35	13	12
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Apoptosis	Caspase-3+ cells count			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	7	7		No change	1 w	>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	BBB				OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	1 mg/kg	6	6		No change	5 w	>=200, <300	>=200, <300	35	13	13
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Apoptosis	Caspase-3+ cells count			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		No change	1 w	>=200, <300	>=200, <300			
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	BBB				OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		No change	5 w	>=200, <300	>=200, <300	35	15,4	13
17433295	17433295	Open PDF	McTigue	McTigue DM, Tripathi R, Wei P, Lash AT.	2007	Exp Neurol	No effect	Non-functional	Inflammation	Rat	SD	Adult	Female	214-245 g	Thoracic	Contusion	Inflammatory cells	macrophage density			OSU Impactor		Systemic	Pioglitazone	Intraperitoneal	10 mg/kg	6	6		No change	1 w	>=200, <300	>=200, <300			
17518539	17518539	Open PDF	Bohnert	Bohnert DM, Purvines S, Shapiro S, Borgens RB.	2007	J Neurotrauma	Positive	Functional	Reflex	Guinea Pig	Not defined	Adult	Female	400 g	Thoracic	Partial transection	Skin muscle reflex	recovery of cutaneus trunci muscle (CTM) (skin muscle) receptive fields		Lateral hemisection			Systemic	Inosine	Subcutaneous	10 mM at 0,25 _l/h	15	15		Increase	5 m	>=400, <500	>=400, <500			
17518539	17518539	Open PDF	Bohnert	Bohnert DM, Purvines S, Shapiro S, Borgens RB.	2007	J Neurotrauma	Positive	Non-functional	Neuronal regeneration	Guinea Pig	Not defined	Adult	Female	400 g	Thoracic	Partial transection	Axonal regeneration	regenerative sprouting of ascending and descending tracts up to the lesoin site		Lateral hemisection			Systemic	Inosine	Subcutaneous	10 mM at 0,25 _l/h	15	15		Increase		>=400, <500	>=400, <500			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Open field				Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Increase		>=200, <300	>=200, <300			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Myelination				Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Increase		>=200, <300	>=200, <300			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Cyst volume	edema, spinal cord water content			Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Decrease		>=200, <300	>=200, <300			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Lesion volume				Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Decrease		>=200, <300	>=200, <300			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Cell loss	increase in neuronal grey matter sparing			Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Decrease		>=200, <300	>=200, <300			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Oxidative stress	MDA level			Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Decrease		>=200, <300	>=200, <300			
17532502	17532502	Open PDF	Ates	Ates O, Cayli SR, Gurses I, Turkoz Y, Tarim O, Cakir CO, Kocak A.	2007	J Clin Neurosci	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	200-250 g	Thoracic	Contusion	Inclined plane test				Weight drop	5 g x 10 cm	Systemic	Riluzole	Intraperitoneal	8 mg/kg	18	18		Increase		>=200, <300	>=200, <300			
17540369	17540369	Open PDF	Massey	Massey JM, Amps J, Viapiano MS, Matthews RT, Wagoner MR, Whitaker CM, Alilain W, Yonkof AL, Khalyfa A, Cooper NG, Silver J, Onifer SM.	2008	Exp Neurol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	275-350 g	Thoracic	Compression	Axonal regeneration	regeneration into gracile nucleus of GFP-labeled DRG implanted rostral to lesion site 14d PI		Dorsal column	Forceps		Local	NT-3 lentivirus	Intraspinal injection		5	6		Increase		>=200, <300	>=300, <400			
17540369	17540369	Open PDF	Massey	Massey JM, Amps J, Viapiano MS, Matthews RT, Wagoner MR, Whitaker CM, Alilain W, Yonkof AL, Khalyfa A, Cooper NG, Silver J, Onifer SM.	2008	Exp Neurol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	275-350 g	Thoracic	Compression	Axonal regeneration	regeneration into gracile nucleus of GFP-labeled DRG implanted rostral to lesion site 14d PI		Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	690 nl at 20 U/ml	4	6		Increase		>=200, <300	>=300, <400			
17608147	17608147	Open PDF	Gok	Gok B, Okutan O, Beskonakli E, Kilinc K.	2007	Chin J Physiol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Inflammatory cells	neutrophil infiltration (MPO activity)			Weight drop	40 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	7	7		Decrease	1 d	>=200, <300	>=200, <300			
17608147	17608147	Open PDF	Gok	Gok B, Okutan O, Beskonakli E, Kilinc K.	2007	Chin J Physiol	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	210-250 g	Thoracic	Contusion	Inclined plane test	early functional scores			Weight drop	40 g x cm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	7	7		Increase	1 d	>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Non-neuronal cell changes	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Schwann cells	Schwann cell infiltration		Unilateral hemisection			Systemic	Erythropoietin (carbamylated)	Intraperitoneal	40 _g/kg	6	6		Increase		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Axonal damage	b-APP staining		Unilateral hemisection			Systemic	Erythropoietin	Intraperitoneal	40 _g/kg	7	6		Decrease		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Lesion volume			Unilateral hemisection			Systemic	Erythropoietin	Intraperitoneal	40 _g/kg	7	6		Decrease		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Apoptosis	TUNEL staining		Unilateral hemisection			Systemic	Erythropoietin (carbamylated)	Intraperitoneal	40 _g/kg	6	6		Decrease		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Lesion volume			Unilateral hemisection			Systemic	Erythropoietin (carbamylated)	Intraperitoneal	40 _g/kg	6	6		Decrease		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Apoptosis	TUNEL staining		Unilateral hemisection			Systemic	Erythropoietin	Intraperitoneal	40 _g/kg	7	6		Decrease		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Non-neuronal cell changes	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Schwann cells	Schwann cell infiltration		Unilateral hemisection			Systemic	Erythropoietin	Intraperitoneal	40 _g/kg	7	6		Increase		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Axonal damage	b-APP staining		Unilateral hemisection			Systemic	Erythropoietin (carbamylated)	Intraperitoneal	40 _g/kg	6	6		Decrease		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Inflammatory cells	macrophage infiltration		Unilateral hemisection			Systemic	Erythropoietin	Intraperitoneal	40 _g/kg	7	6		No change		>=200, <300	>=200, <300			
17614942	17614942	Open PDF	King	King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT.	2007	Eur J Neurosci	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	200-220 g	Thoracic	Partial transection	Inflammatory cells	macrophage infiltration		Unilateral hemisection			Systemic	Erythropoietin (carbamylated)	Intraperitoneal	40 _g/kg	6	6		No change		>=200, <300	>=200, <300			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Walking analysis	foot coordination			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h or 2h and 45 mg/kg at 12,24,36,48,60,72h	20	20	3	Increase		>=200, <300	>=300, <400			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h or 2h and 45 mg/kg at 12,24,36,48,60,72h	6	3	3	Decrease		>=200, <300	>=300, <400			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h or 2h and 45 mg/kg at 12,24,36,48,60,72h	6	3	3	Decrease		>=200, <300	>=300, <400			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h	20	20	3	Increase		>=200, <300	>=300, <400	35	11	8
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Walking analysis	gridwalk			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h or 2h and 45 mg/kg at 12,24,36,48,60,72h	20	20	3	Increase		>=200, <300	>=300, <400			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Axonal damage				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h or 2h and 45 mg/kg at 12,24,36,48,60,72h	6	3	3	Decrease		>=200, <300	>=300, <400			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	Inclined plane test				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h or 2h and 45 mg/kg at 12,24,36,48,60,72h	6	3	3	Increase		>=200, <300	>=300, <400			
17634369	17634369	Open PDF	Yune	Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH.	2007	J Neurosci	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	250-300 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 2h and 45 mg/kg at 12,24,36,48,60,72h	20	20	3	Increase		>=200, <300	>=300, <400	35	11	8
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	MCP-1			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Oxidative stress	iNOS			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Oxidative stress	iNOS			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Oxidative stress	nitrotyrosine			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	COX-2			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Functional	Locomotor test	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	BBB	hindlimb motor function			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Increase		<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	TUNEL			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	mRNA for TNF_			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL1_			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Inflammatory cells	MPO activity and expression			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Lesion volume	loss of tissue at lesion area			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Lesion volume	loss of myelin at lesion area			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	BAX			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Functional	Locomotor test	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	BBB	hindlimb motor function			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Increase		<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	BAX			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Lesion volume	loss of tissue at lesion area			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL6			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	Bcl-2			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Increase	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	TUNEL			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Inflammatory cells	MPO activity and expression			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	Bcl-2			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Increase	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Lesion volume	loss of tissue at lesion area			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Inflammatory cells	MPO activity and expression			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL6			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	mRNA for TNF_			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	TUNEL			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL1_			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	MCP-1			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Functional	Locomotor test	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	BBB	hindlimb motor function			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Increase		<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	COX-2			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Lesion volume	loss of myelin at lesion area			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Oxidative stress	iNOS			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Functional	Locomotor test	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	BBB				Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Increase		<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	BAX			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL6			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Oxidative stress	nitrotyrosine			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	mRNA for TNF_			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	MCP-1			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Oxidative stress	nitrotyrosine			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL1_			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Secondary degeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Apoptosis	Bcl-2			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Increase	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	Positive	Non-functional	Inflammation	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Pro-inflammatory Cytokine	COX-2			Clip	24 g	Systemic	Estrogen	Subcutaneous	300 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17704735	17704735	Open PDF	Cuzzocrea	Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Di Paola R, Mui_ C, Crisafulli C, Peli A, Bramanti P, Chaudry IH.	2008	Shock	No effect	Non-functional	Neuronal regeneration	Mouse	CD-1	Adult	Male	25-30 g	Thoracic	Compression	Myelination	loss of myelin at lesion area			Clip	24 g	Systemic	Estrogen	Subcutaneous	600 _g/kg	10	10	10	Decrease	1 d	<100	<100			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	nerve growth factor (NGF)  expression epicenter			Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		Increase	1 w	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	glial-derived neurotrophic factor expression			Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		Increase	1 w	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	nerve growth factor (NGF) expression caudally			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		Increase	3 d	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	glial-derived neurotrophic factor expression			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		Increase	1 w	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	nerve growth factor (NGF) expression rostrally			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		Increase	3 d	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	nerve growth factor (NGF)  expression epicenter			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		Increase	1 w	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	Positive	Functional	Locomotor test	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	BBB		13.9 [9.5]		Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		Increase		>=200, <300	>=200, <300	28	13,9	9,5
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	nerve growth factor (NGF) expression rostrally			Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		No change	3 d	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	nerve growth factor (NGF) expression caudally			Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		No change	3 d	>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	BDNF expression			Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		No change		>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	basic fibroblast growth factor-2 expression			Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		No change		>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	BDNF expression			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		No change		>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	Neurotrophic factors	basic fibroblast growth factor-2 expression			Univ of Trieste Impactor	1 N	Systemic	Erythropoietin	Intraperitoneal	1000 U/kg	8	8		No change		>=200, <300	>=200, <300			
17936749	17936749	Open PDF	Fumagalli	Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A.	2008	Eur J Pharmacol	No effect	Functional	Locomotor test	Rat	SD	Adult	Not defined	240-260 g	Thoracic	Contusion	BBB		9.0 [9.5]		Univ of Trieste Impactor	1 N	Systemic	Methylprednisolone (MP)	Intraperitoneal	30 mg/kg	8	8		No change		>=200, <300	>=200, <300	28	9	9,5
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	narrow beam		Hemisection			Local	Deactivated Chondroitinase ABC	Gelfoam	0,025 U	2	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	ladder		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,025 U	3	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	pegboard,quicker rate of recovery in the ChABC group (p < 0,05); at 16 and 20 wk PI, ChABC were better than controls		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,025 U	3	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	pegboard		Hemisection			Local	Deactivated Chondroitinase ABC	Gelfoam	0,025 U	2	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	ladder		Hemisection			Local	Deactivated Chondroitinase ABC	Gelfoam	0,025 U	2	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Non-functional	Neuronal regeneration	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Axonal regeneration	sprouting of 5-HT fibers into the rostral portion of the lesion 		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,025 U	3	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	Positive	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	narrow beam		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,025 U	3	3		Increase						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	No effect	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	plantar stepping		Hemisection			Local	Deactivated Chondroitinase ABC	Gelfoam	0,025 U	2	3		No change						
17936753	17936753	Open PDF	Tester	Tester NJ, Howland DR.	2008	Exp Neurol	No effect	Functional	Locomotor test	Cat	Not defined	Adult	Female		Thoracic	Partial transection	Walking analysis	plantar stepping		Hemisection			Local	Chondroitinase ABC	Gelfoam	0,025 U	3	3		No change						
18056009	18056009	Open PDF	Cao	Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.	2008	Neurorehabil Neural Repair	Positive	Functional	Locomotor test	Rat	SD	Adult	Female		Cervical	Partial transection	Walking analysis	forelimb use		Right lateral funiculus			Local	NOGO receptor antagonist	Intrathecal	500 mM, 0,3 ml/h	8	7		Increase						
18056009	18056009	Open PDF	Cao	Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.	2008	Neurorehabil Neural Repair	Positive	Functional	Locomotor test	Rat	SD	Adult	Female		Cervical	Partial transection	Walking analysis	gait use		Right lateral funiculus			Local	NOGO receptor antagonist	Intrathecal	500 mM, 0,3 ml/h	8	7		Increase						
18056009	18056009	Open PDF	Cao	Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.	2008	Neurorehabil Neural Repair	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female		Cervical	Partial transection	Axonal regeneration	rubrospinal tract and 5-HT sprouting		Right lateral funiculus			Local	NOGO receptor antagonist	Intrathecal	500 mM, 0,3 ml/h	8	7		Increase						
18056009	18056009	Open PDF	Cao	Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.	2008	Neurorehabil Neural Repair	Negative	Functional	Locomotor test	Rat	SD	Adult	Female		Cervical	Partial transection	Walking analysis	gait use		Right lateral funiculus			Local	NOGO receptor antagonist	Intrathecal	500 mM, 0,3 ml/h	8	7		Decrease						
18056009	18056009	Open PDF	Cao	Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.	2008	Neurorehabil Neural Repair	Negative	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female		Cervical	Partial transection	Axonal regeneration	rubrospinal tract and 5-HT sprouting		Right lateral funiculus			Local	NOGO receptor antagonist	Intrathecal	500 mM, 0,3 ml/h	8	7		Decrease						
18056009	18056009	Open PDF	Cao	Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.	2008	Neurorehabil Neural Repair	Negative	Functional	Locomotor test	Rat	SD	Adult	Female		Cervical	Partial transection	Walking analysis	forelimb use		Right lateral funiculus			Local	NOGO receptor antagonist	Intrathecal	500 mM, 0,3 ml/h	8	7		Decrease						
18065151	18065151	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Fontana E, Gorio A, De Biasi S.	2008	Neuroscience	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Angiogenesis	total volume occupied by microvessels in injured cord			Univ of Trieste Impactor	Modified injury device	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	14	14		Increase		>=200, <300	>=200, <300			
18065151	18065151	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Fontana E, Gorio A, De Biasi S.	2008	Neuroscience	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	BBB		15 [8]		Univ of Trieste Impactor	Modified injury device	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	14	14		Increase	4 w	>=200, <300	>=200, <300	28	15	8
18065151	18065151	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Fontana E, Gorio A, De Biasi S.	2008	Neuroscience	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Astrogliosis	GFAP immunoreactivity			Univ of Trieste Impactor	Modified injury device	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	14	14		Decrease		>=200, <300	>=200, <300			
18065151	18065151	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Fontana E, Gorio A, De Biasi S.	2008	Neuroscience	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Lesion volume	tissue sparing			Univ of Trieste Impactor	Modified injury device	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	14	14		Decrease		>=200, <300	>=200, <300			
18065151	18065151	Open PDF	Vitellaro-Zuccarello	Vitellaro-Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Fontana E, Gorio A, De Biasi S.	2008	Neuroscience	No effect	Non-functional	Molecular changes	Rat	SD	Adult	Male	240-270 g	Thoracic	Contusion	Growth inhibitor expression	CSPG in and around lesion			Univ of Trieste Impactor	Modified injury device	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	14	14		No change		>=200, <300	>=200, <300			
18158149	18158149	Open PDF	Garcia-Alias	Garc_a-Al_as G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW.	2008	Exp Neurol	Positive	Functional	Reflex	Rat	Lister hooded	Adult	Not defined	250-300 g	Cervical	Compression	Placing response			Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	6 _l at 100 U/ml = 0,6 U	6	6		Increase		>=200, <300	>=300, <400			
18158149	18158149	Open PDF	Garcia-Alias	Garc_a-Al_as G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW.	2008	Exp Neurol	Positive	Functional	Locomotor test	Rat	Lister hooded	Adult	Not defined	250-300 g	Cervical	Compression	Forelimb strength	forepaw stride length		Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	6 _l at 100 U/ml = 0,6 U	6	6		Increase		>=200, <300	>=300, <400			
18158149	18158149	Open PDF	Garcia-Alias	Garc_a-Al_as G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW.	2008	Exp Neurol	Positive	Functional	Locomotor test	Rat	Lister hooded	Adult	Not defined	250-300 g	Cervical	Compression	Manual dexterity	staircase pellet retrieval task		Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	6 _l at 100 U/ml = 0,6 U	6	6		Increase		>=200, <300	>=300, <400			
18158149	18158149	Open PDF	Garcia-Alias	Garc_a-Al_as G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW.	2008	Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	Lister hooded	Adult	Not defined	250-300 g	Cervical	Compression	Apoptosis	dieback		Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	6 _l at 100 U/ml = 0,6 U	6	6		Decrease		>=200, <300	>=300, <400			
18158149	18158149	Open PDF	Garcia-Alias	Garc_a-Al_as G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW.	2008	Exp Neurol	Positive	Non-functional	Neuronal regeneration	Rat	Lister hooded	Adult	Not defined	250-300 g	Cervical	Compression	Axonal regeneration	axonal growth		Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	6 _l at 100 U/ml = 0,6 U	6	6		Increase		>=200, <300	>=300, <400			
18158149	18158149	Open PDF	Garcia-Alias	Garc_a-Al_as G, Lin R, Akrimi SF, Story D, Bradbury EJ, Fawcett JW.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	Lister hooded	Adult	Not defined	250-300 g	Cervical	Compression	Forelimb strength	grip strength		Dorsal column	Forceps		Local	Chondroitinase ABC	Intraspinal injection	6 _l at 100 U/ml = 0,6 U	6	6		No change		>=200, <300	>=300, <400			
18194520	18194520	Open PDF	Beaud	Beaud ML, Schmidlin E, Wannier T, Freund P, Bloch J, Mir A, Schwab ME, Rouiller EM.	2008	BMC Neurosci	No effect	Non-functional	Neuroprotection	Monkey	Macaque	Adult	Not defined		Cervical	Partial transection	Cell loss	atrophy of lesioned cell bodies		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	5	4		No change						
18234196	18234196	Open PDF	Steward	Steward O, Sharp K, Yee KM, Hofstadter M.	2008	Exp Neurol	No effect	Functional	Locomotor test	Mouse	C57/BL6	Adult	Female		Thoracic	Partial transection	Walking analysis			Dorsal hemisection			Local	NOGO receptor antagonist	Subcutaneous		10	10		No change						
18234196	18234196	Open PDF	Steward	Steward O, Sharp K, Yee KM, Hofstadter M.	2008	Exp Neurol	No effect	Non-functional	Neuronal regeneration	Mouse	C57/BL6	Adult	Female		Thoracic	Partial transection	Axonal regeneration	axonal sprouting/regeneration		Dorsal hemisection			Local	NOGO receptor antagonist	Subcutaneous		10	10		No change						
18280653	18280653	Open PDF	Saganova	Saganov_ K, Orend_cov_ J, C_zkov_ D, Vanick_ I.	2008	Neurosci Lett	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	300-330 g	Thoracic	Compression	Lesion volume				Balloon	12.5 _l x 5 min	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 1h and 45 mg/kg at 12, 24, 36, 48, 60, 72, 84, 96, 108, 120h	12	12		Decrease		>=300, <400	>=300, <400			
18280653	18280653	Open PDF	Saganova	Saganov_ K, Orend_cov_ J, C_zkov_ D, Vanick_ I.	2008	Neurosci Lett	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	300-330 g	Thoracic	Compression	Lesion volume				Balloon	12.5 _l x 5 min	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 1h and 45 mg/kg at 12h, 24h	12	12		Decrease		>=300, <400	>=300, <400			
18280653	18280653	Open PDF	Saganova	Saganov_ K, Orend_cov_ J, C_zkov_ D, Vanick_ I.	2008	Neurosci Lett	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Not defined	300-330 g	Thoracic	Compression	BBB				Balloon	12.5 _l x 5 min	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 1h and 45 mg/kg at 12, 24, 36, 48, 60, 72, 84, 96, 108, 120h	12	12		No change	4 w	>=300, <400	>=300, <400	28	13	13
18280653	18280653	Open PDF	Saganova	Saganov_ K, Orend_cov_ J, C_zkov_ D, Vanick_ I.	2008	Neurosci Lett	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Not defined	300-330 g	Thoracic	Compression	BBB				Balloon	12.5 _l x 5 min	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 1h and 45 mg/kg at 12h, 24h	12	12		No change	4 w	>=300, <400	>=300, <400	28	13	13
18309506	18309506	Open PDF	Kontogeorgakos 	Kontogeorgakos VA, Voulgaris S, Korompilias AV, Vekris M, Polyzoidis KS, Bourantas K, Beris AE.	2009	Arch Orthop Trauma Surg	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	270-300 g	Thoracic	Compression	BBB	mean score	14 [8.2]		Aneurysm Clip	0.7 N	Systemic	Erythropoietin	Subcutaneous	1000 IU	10	10		Increase		>=200, <300	>=300, <400	42	14	8,2
18309506	18309506	Open PDF	Kontogeorgakos 	Kontogeorgakos VA, Voulgaris S, Korompilias AV, Vekris M, Polyzoidis KS, Bourantas K, Beris AE.	2009	Arch Orthop Trauma Surg	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	270-300 g	Thoracic	Compression	BBB	mean score	17 [8.2]		Aneurysm Clip	0.7 N	Systemic	Erythropoietin	Subcutaneous	1000 IU	10	10		Increase		>=200, <300	>=300, <400	42	17	8,2
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Footprint analysis				OSU Impactor	200-260 kdyn	Systemic	Erythropoietin	Intravenous	5000 IU/kg	12	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Footprint analysis				OSU Impactor	200-260 kdyn	Systemic	Darbepoetin	Intravenous	10 mg/kg	11	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Walking analysis	footfall analysis			OSU Impactor	200-260 kdyn	Systemic	Darbepoetin	Intravenous	10 mg/kg	11	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	BBB				OSU Impactor	200-260 kdyn	Systemic	Darbepoetin	Intravenous	10 mg/kg	11	11		No change		>=300, <400	>=300, <400	42	11,6	11,3
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Sensory test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Hindpaw sensation				OSU Impactor	200-260 kdyn	Systemic	Erythropoietin	Intravenous	5000 IU/kg	12	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	BBB				OSU Impactor	200-260 kdyn	Systemic	Erythropoietin	Intravenous	5000 IU/kg	12	11		No change		>=300, <400	>=300, <400	42	11,7	11,3
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Walking analysis	footfall analysis			OSU Impactor	200-260 kdyn	Systemic	Erythropoietin	Intravenous	5000 IU/kg	12	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Functional	Sensory test	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Hindpaw sensation				OSU Impactor	200-260 kdyn	Systemic	Darbepoetin	Intravenous	10 mg/kg	11	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Lesion volume	sparing of white or grey matter			OSU Impactor	200-260 kdyn	Systemic	Darbepoetin	Intravenous	10 mg/kg	11	11		No change		>=300, <400	>=300, <400			
18313052	18313052	Open PDF	Mann	Mann C, Lee JH, Liu J, Stammers AM, Sohn HM, Tetzlaff W, Kwon BK.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	320-340 g	Thoracic	Contusion	Lesion volume	sparing of white or grey matter			OSU Impactor	200-260 kdyn	Systemic	Erythropoietin	Intravenous	5000 IU/kg	12	11		No change		>=300, <400	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Lesion volume	area of GFAP in lesion			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		Decrease	1 w	>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	BBB				Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	6	6		Increase		>=200, <300	>=300, <400	28	18,6	15,3
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL-1_ in lesion			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		Decrease	6 h	>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Walking analysis	narrow beam crossing			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	6	6		Increase	1 w	>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Non-functional	Non-neuronal cell changes	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Extracellular matrix	vimentin			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		Increase		>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	BBB				Clip	20 g	Systemic	Estrogen	Intraperitoneal	0,1 mg/kg	6	6		Increase		>=200, <300	>=300, <400	28	16	15,3
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Lesion volume				Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		Decrease	1 w	>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Inflammatory cells	macrophages (CD68) in lesion			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		Decrease		>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL-1_/IL-1 ra ratio			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		No change		>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL-6			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		No change	6 h	>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	cytokines			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		No change		>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	No effect	Non-functional	Inflammation	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	IL-1 receptor antagonist			Clip	20 g	Systemic	Estrogen	Intraperitoneal	4 mg/kg	3	3		No change		>=200, <300	>=300, <400			
18316064	18316064	Open PDF	Ritz	Ritz MF, Hausmann ON.	2008	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Male	250-300 g	Thoracic	Compression	lesion volume				Clip	20 g	Systemic	Estrogen	Intraperitoneal	0,1 mg/kg	3	3		No change		>=200, <300	>=300, <400			
18317490	18317490	Open PDF	Morino	Morino T, Ogata T, Takeba J, Yamamoto H.	2008	Spinal Cord	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	200-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	TNF-_			Clip	20 g	Systemic	Hypothermia		33_C	5	5	8	Decrease		>=200, <300	>=300, <400			
18317490	18317490	Open PDF	Morino	Morino T, Ogata T, Takeba J, Yamamoto H.	2008	Spinal Cord	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	200-300 g	Thoracic	Compression	Inflammatory cells	isolectin-positive cells (microglia)			Clip	20 g	Systemic	Hypothermia		33_C	6	6	8	Decrease		>=200, <300	>=300, <400			
18317490	18317490	Open PDF	Morino	Morino T, Ogata T, Takeba J, Yamamoto H.	2008	Spinal Cord	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	200-300 g	Thoracic	Compression	Open field	standing frequency returned to the normal levels in the hypothermic			Clip	20 g	Systemic	Hypothermia		33_C	6	6	8	Increase	3 d	>=200, <300	>=300, <400			
18351400	18351400	Open PDF	Ha	Ha KY, Kim YH, Rhyu KW, Kwon SE.	2008	Eur Spine J	Positive	Non-functional	Inflammation	Rat	SD	Adult	Male	300-350 g	Thoracic	Contusion	Inflammation				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	8	8		Decrease		>=300, <400	>=300, <400			
18351400	18351400	Open PDF	Ha	Ha KY, Kim YH, Rhyu KW, Kwon SE.	2008	Eur Spine J	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	300-350 g	Thoracic	Contusion	Apoptosis				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	8	8		Decrease		>=300, <400	>=300, <400			
18351400	18351400	Open PDF	Ha	Ha KY, Kim YH, Rhyu KW, Kwon SE.	2008	Eur Spine J	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	300-350 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	8	8		Decrease		>=300, <400	>=300, <400			
18351400	18351400	Open PDF	Ha	Ha KY, Kim YH, Rhyu KW, Kwon SE.	2008	Eur Spine J	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	300-350 g	Thoracic	Contusion	Inclined plane test				NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	8	8		Increase	1 w	>=300, <400	>=300, <400			
18351400	18351400	Open PDF	Ha	Ha KY, Kim YH, Rhyu KW, Kwon SE.	2008	Eur Spine J	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	300-350 g	Thoracic	Contusion	Open field	6-point locomotor score			NYU impactor	10 g x 25 mm	Systemic	Minocycline	Intraperitoneal	30 mg/kg	8	8		Increase		>=300, <400	>=300, <400			
18353313	18353313	Open PDF	Tom	Tom VJ, Houl_ JD.	2008	Exp Neurol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	225-250 g	Cervical	Aspiration lesion	Growth inhibitor degradation	digestion of CSPG (based on 2B6 immunoreactivity)		Right dorsal quadrant of ~1mm_			Local	Chondroitinase ABC	Intraspinal injection	1 _l of 20 U/ml	3	5		Increase		>=200, <300	>=200, <300			
18353313	18353313	Open PDF	Tom	Tom VJ, Houl_ JD.	2008	Exp Neurol	No effect	Non-functional	Inflammation	Rat	SD	Adult	Female	225-250 g	Cervical	Aspiration lesion	Inflammatory cells	inflammatory response (ED1 + macrophages / microglia)		Right dorsal quadrant of ~1mm_			Local	Chondroitinase ABC	Intraspinal injection	1 _l of 20 U/ml	3	5		No change		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Growth inhibitor degradation	CSPG cleaved products (2B6 immunoreactivity)		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,06 U in 6 _l (low dose)	8	5		Increase		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Growth inhibitor expression	CSPG, NG-2 and CS56 expression		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,06 U in 6 _l (low dose)	8	5		Decrease		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Axonal regeneration	number and length of axons		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,18 U in 6 _l (high dose)	9	5		Increase		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Growth inhibitor expression	CSPG, NG-2 and CS56 expression		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,18 U in 6 _l (high dose)	9	5		Decrease		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Axonal regeneration	number and length of axons		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,06 U in 6 _l (low dose)	8	5		Increase		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Growth inhibitor degradation	CSPG cleaved products (2B6 immunoreactivity)		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,18 U in 6 _l (high dose)	9	5		Increase		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Extracellular matrix	laminin immunoreactivity in the cord		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,06 U in 6 _l (low dose)	8	5		No change		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Astrogliosis	GFAP immunoreactivity in the cord		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,18 U in 6 _l (high dose)	9	5		No change		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Extracellular matrix	laminin immunoreactivity in the cord		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,18 U in 6 _l (high dose)	9	5		No change		>=200, <300	>=200, <300			
18486695	18486695	Open PDF	Shields	Shields LB, Zhang YP, Burke DA, Gray R, Shields CB.	2008	Surg Neurol	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	200-225 g	Cervical	Partial transection	Astrogliosis	GFAP immunoreactivity in the cord		Dorsal hemisection	Vibraknife		Local	Chondroitinase ABC		0,06 U in 6 _l (low dose)	8	5		No change		>=200, <300	>=200, <300			
18508036	18508036	Open PDF	Wannier-Morino	Wannier-Morino P, Schmidlin E, Freund P, Belhaj-Saif A, Bloch J, Mir A, Schwab ME, Rouiller EM, Wannier T.	2008	Brain Res	No effect	Non-functional	Neuroprotection	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Cell loss	prevention of shrinkage		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	4		No change		>=500	>=500			
18508036	18508036	Open PDF	Wannier-Morino	Wannier-Morino P, Schmidlin E, Freund P, Belhaj-Saif A, Bloch J, Mir A, Schwab ME, Rouiller EM, Wannier T.	2008	Brain Res	No effect	Non-functional	Neuroprotection	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Cell loss	prevention of reduction of number of rubrospinal neurons in the contralesional red nucleus		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	4		No change		>=500	>=500			
18584320	18584320	Open PDF	Gonzalez	Gonz_lez SL, L_pez-Costa JJ, Labombarda F, Deniselle MC, Guennoun R, Schumacher M, De Nicola AF.	2009	Cell Mol Neurobiol	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cytoskeletal integrity	cytoskeletal disruption (reduced MAP2 staining in dendrites)					Systemic	Progesterone	Subcutaneous	4 mg/kg	5	5	5	Decrease	75 h	>=200, <300	>=300, <400			
18584320	18584320	Open PDF	Gonzalez	Gonz_lez SL, L_pez-Costa JJ, Labombarda F, Deniselle MC, Guennoun R, Schumacher M, De Nicola AF.	2009	Cell Mol Neurobiol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Apoptosis	chromatolytic cytoplasm					Systemic	Progesterone	Subcutaneous	4 mg/kg	5	5	5	Decrease	75 h	>=200, <300	>=300, <400			
18584320	18584320	Open PDF	Gonzalez	Gonz_lez SL, L_pez-Costa JJ, Labombarda F, Deniselle MC, Guennoun R, Schumacher M, De Nicola AF.	2009	Cell Mol Neurobiol	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Non-neuronal cells pathol.	dispersion of the nucleoplasm and eccentric location within the cell					Systemic	Progesterone	Subcutaneous	4 mg/kg	5	5	5	Decrease	75 h	>=200, <300	>=300, <400			
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		3 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Cyclosporine-A	Intraperitoneal	5;2.5;2.5 mg/kg	7	7		No change	6 w				3	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		5 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Methylprednisolone (MP)	Intraperitoneal	30;30;30 mg/kg	7	7		No change	6 w				5	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		4 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Melatonin	Intraperitoneal	10;10;10 mg/kg	7	7		No change	5 w				4	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	5 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Melatonin	Intraperitoneal	10;10;10 mg/kg	7	7		No change	6 w				5	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Lesion volume	amount of spared tissue [mm2]	10 [10]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Melatonin	Intraperitoneal	10;10;10 mg/kg	7	7		No change	6 w				10	10
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB		11 [11]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Melatonin	Intraperitoneal	10;10;10 mg/kg	7	7		No change	6 w			42	11	11
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		4 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Melatonin	Intraperitoneal	10;10;10 mg/kg	7	7		No change	6 w				4	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		5 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Methylprednisolone (MP)	Intraperitoneal	30;30;30 mg/kg	7	7		No change	5 w				5	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		3 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	2000;2000;2000 U/kg	7	7		No change	5 w				3	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB		10.5 [11]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Cyclosporine-A	Intraperitoneal	5;2.5;2.5 mg/kg	7	7		No change	6 w			42	10,5	11
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		3 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Cyclosporine-A	Intraperitoneal	5;2.5;2.5 mg/kg	7	7		No change	5 w				3	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Lesion volume	amount of spared tissue [mm2]	9 [10]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	2000;2000;2000 U/kg	7	7		No change	6 w				9	10
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	6 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	2000;2000;2000 U/kg	7	7		No change	5 w				6	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB		11 [11]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	2000;2000;2000 U/kg	7	7		No change	6 w			42	11	11
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Lesion volume	amount of spared tissue [mm2]	11 [10]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Methylprednisolone (MP)	Intraperitoneal	30;30;30 mg/kg	7	7		No change	6 w				11	10
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB		11 [11]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Methylprednisolone (MP)	Intraperitoneal	30;30;30 mg/kg	7	7		No change	6 w			42	11	11
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Non-functional	Secondary degeneration	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Lesion volume	amount of spared tissue [mm2]	9 [10 ]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Cyclosporine-A	Intraperitoneal	5;2.5;2.5 mg/kg	7	7		No change	6 w				9	10
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	9 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Methylprednisolone (MP)	Intraperitoneal	30;30;30 mg/kg	7	7		No change	6 w				9	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	7 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Methylprednisolone (MP)	Intraperitoneal	30;30;30 mg/kg	7	7		No change	5 w				7	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	BBB subscore		5 [5]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	2000;2000;2000 U/kg	7	7		No change	6 w				5	5
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	8 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	2000;2000;2000 U/kg	7	7		No change	6 w				8	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	No effect	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	2 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Melatonin	Intraperitoneal	10;10;10 mg/kg	7	7		No change	5 w				2	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	Negative	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	2 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Cyclosporine-A	Intraperitoneal	5;2.5;2.5 mg/kg	7	7		Decrease	6 w				2	6
18607385	18607385	Open PDF	Guizar-Sahagun	Gu_zar-Sahag_n G, Rodr_guez-Balderas CA, Franco-Bourland RE, Mart_nez-Cruz A, Grijalva I, Ibarra A, Madrazo I.	2009	Spinal Cord	Negative	Functional	Locomotor test	Rat	Long-Evans	Adult	Female	n/a	Thoracic	Contusion	Rearing test	Rearing cylinder test, number of rearing events in 4 min	1 [6]	n/a	NYU impactor	10 g x 12.5 mm	Systemic	Cyclosporine-A	Intraperitoneal	5;2.5;2.5 mg/kg	7	7		Decrease	5 w				1	6
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	240-260 g	Thoracic	Contusion	Cyst volume	Cavitation			NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	12	12		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	240-260 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	15	15		No change	7 w	>=200, <300	>=200, <300	30	11,4	11,7
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220-280 g	Thoracic	Compression	Lesion volume	preservation of tissue at injury epicenter			Aneurysm Clip	20 g	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	10	10		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	240-260 g	Thoracic	Contusion	Lesion volume	preservation of tissue at injury epicenter			NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	12	12		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220-280 g	Thoracic	Compression	Lesion volume	preservation of tissue at injury epicenter			Aneurysm Clip	50 g	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	10	10		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	240-260 g	Thoracic	Contusion	Cyst volume	Cavitation			NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	12	12		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220-280 g	Thoracic	Compression	Lesion volume	preservation of tissue at injury epicenter			Aneurysm Clip	50 g	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	10	10		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Female	220-280 g	Thoracic	Compression	BBB				Aneurysm Clip	20 g	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	10	10		No change	4 w	>=200, <300	>=200, <300	28	11,3	10,9
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	220-280 g	Thoracic	Compression	Lesion volume	preservation of tissue at injury epicenter			Aneurysm Clip	20 g	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	10	10		No change		>=200, <300	>=200, <300			
18625498	18625498	Open PDF	Pinzon	Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.	2008	Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	240-260 g	Thoracic	Contusion	Lesion volume	preservation of tissue at injury epicenter			NYU impactor	10 g x 12.5 mm	Systemic	Erythropoietin	Intraperitoneal	5000 IU/kg	12	12		No change		>=200, <300	>=200, <300			
18633702	18633702	Open PDF	Duz	Duz B, Kaplan M, Bilgic S, Korkmaz A, Kahraman S.	2009	Neurochem Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-350 g	Thoracic	Compression	Oxidative stress	reduction of GSH-peroxidase levels			Clip	50 g	Systemic	Hypothermia		27-29_C	14	14	7	Decrease		>=200, <300	>=300, <400			
18633702	18633702	Open PDF	Duz	Duz B, Kaplan M, Bilgic S, Korkmaz A, Kahraman S.	2009	Neurochem Res	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-350 g	Thoracic	Compression	Oxidative stress	reduction of lipid peroxidation			Clip	50 g	Systemic	Hypothermia		27-29_C	14	14	7	Decrease		>=200, <300	>=300, <400			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Oxidative stress	malonyldialdehyde (MDA) level			Epidural Clip	40 g	Systemic	Ketamine	Intraperitoneal	100 mg/kg	7	7	7	Decrease	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Oxidative stress	Anti-oxidant agent release:catalase level			Epidural Clip	40 g	Systemic	Erythropoietin	Intraperitoneal	150 IU/kg	7	7	7	Increase	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Oxidative stress	malonyldialdehyde (MDA) level			Epidural Clip	40 g	Systemic	Erythropoietin	Intraperitoneal	150 IU/kg	7	7	7	Decrease	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Pro-inflammatory Cytokine	TNF-_ level			Epidural Clip	40 g	Systemic	Erythropoietin	Intraperitoneal	150 IU/kg	7	7	7	Decrease	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Oxidative stress	Anti-oxidant agent release:glutathione (GSH) level			Epidural Clip	40 g	Systemic	Erythropoietin	Intraperitoneal	150 IU/kg	7	7	7	Increase	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Pro-inflammatory Cytokine	TNF-_ level			Epidural Clip	40 g	Systemic	Ketamine	Intraperitoneal	100 mg/kg	7	7	7	Decrease	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Oxidative stress	Anti-oxidant agent release:glutathione (GSH) level			Epidural Clip	40 g	Systemic	Ketamine	Intraperitoneal	100 mg/kg	7	7	7	Increase	12 h	>=200, <300	>=200, <300			
18635178	18635178	Open PDF	Yazihan	Yazihan N, Uzuner K, Salman B, Vural M, Koken T, Arslantas A.	2008	Injury	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Not defined	200-220 g	Thoracic	Compression	Oxidative stress	Anti-oxidant agent release:catalase level			Epidural Clip	40 g	Systemic	Ketamine	Intraperitoneal	100 mg/kg	7	7	7	No change	12 h	>=200, <300	>=200, <300			
18838063	18838063	Open PDF	Pinzon	Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.	2008	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	220-280 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 12.5 mm	Systemic	Minocycline	Intravenous	90 mg/kg at 0h and 45 mg/kg at 12h,24h	15	7		No change		>=200, <300	>=200, <300			
18838063	18838063	Open PDF	Pinzon	Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.	2008	Brain Res	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	220-280 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 12.5 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h and 45 mg/kg at 12h,24h	15	8		No change		>=200, <300	>=200, <300	42	12,1	11,8
18838063	18838063	Open PDF	Pinzon	Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.	2008	Brain Res	No effect	Functional	Locomotor test	Rat	SD	Adult	Male	220-280 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 12.5 mm	Systemic	Minocycline	Intravenous	90 mg/kg at 0h and 45 mg/kg at 12h,24h	15	7		No change		>=200, <300	>=200, <300	42	12	11,8
18838063	18838063	Open PDF	Pinzon	Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.	2008	Brain Res	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	220-280 g	Thoracic	Contusion	Lesion volume				NYU impactor	10 g x 12.5 mm	Systemic	Minocycline	Intraperitoneal	90 mg/kg at 0h and 45 mg/kg at 12h,24h	15	8		No change		>=200, <300	>=200, <300			
18849175	18849175		Marchand	Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB.	2008	Eur J Pain	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Male	220-250 g	Thoracic	Partial transection	Neuronal activity	c-fos expression		Left			Systemic	Minocycline	Intraperitoneal	40 mg/kg	8	8	8	Increase		>=200, <300	>=200, <300			
18849175	18849175		Marchand	Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB.	2008	Eur J Pain	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Male	220-250 g	Thoracic	Partial transection	Inflammatory cells	microglial activation		Left			Systemic	Minocycline	Intraperitoneal	40 mg/kg	8	8	8	Decrease		>=200, <300	>=200, <300			
18849175	18849175		Marchand	Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB.	2008	Eur J Pain	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	220-250 g	Thoracic	Partial transection	Thermal hyperalgesia			Left			Systemic	Minocycline	Intraperitoneal	40 mg/kg	8	8	8	Decrease	2 w	>=200, <300	>=200, <300			
18849175	18849175		Marchand	Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB.	2008	Eur J Pain	Positive	Functional	Sensory test	Rat	Wistar	Adult	Male	220-250 g	Thoracic	Partial transection	Mechanical allodynia			Left			Systemic	Minocycline	Intraperitoneal	40 mg/kg	8	8	8	Decrease	2 w	>=200, <300	>=200, <300			
18930033	18930033	Open PDF	Xia	Xia Y, Zhao T, Li J, Li L, Hu R, Hu S, Feng H, Lin J.	2008	Biochem Biophys Res Commun	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	250-300 g	Thoracic	Partial transection	Astrogliosis	vimentin and GFAP expression at lesion site		Lateral hemisection			Local	Vimentin anti-sense cDNA	Intraspinal injection	6 _l, titer 3,9 x 108 cfu/ml	3	3		Decrease		>=200, <300	>=300, <400			
18930033	18930033	Open PDF	Xia	Xia Y, Zhao T, Li J, Li L, Hu R, Hu S, Feng H, Lin J.	2008	Biochem Biophys Res Commun	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	250-300 g	Thoracic	Partial transection	Glycosaminoglycans (chondroitin sulfate proteoglycans)	CSPGs (CS-56) immunostaining in the scar		Lateral hemisection			Local	Chondroitinase ABC	Intraspinal injection	6 _l of 10 U/ml	3	3		Decrease		>=200, <300	>=300, <400			
18930033	18930033	Open PDF	Xia	Xia Y, Zhao T, Li J, Li L, Hu R, Hu S, Feng H, Lin J.	2008	Biochem Biophys Res Commun	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Partial transection	Cyst volume	cystic cavity		Lateral hemisection			Local	Chondroitinase ABC	Intraspinal injection	6 _l of 10 U/ml	3	3		Decrease		>=200, <300	>=300, <400			
18930033	18930033	Open PDF	Xia	Xia Y, Zhao T, Li J, Li L, Hu R, Hu S, Feng H, Lin J.	2008	Biochem Biophys Res Commun	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Female	250-300 g	Thoracic	Partial transection	Astrogliosis	vimentin and GFAP expression at lesion site		Lateral hemisection			Local	Chondroitinase ABC	Intraspinal injection	6 _l of 10 U/ml	3	3		No change		>=200, <300	>=300, <400			
19053058	19053058	Open PDF	Labombarda	Labombarda F, Gonz_lez SL, Lima A, Roig P, Guennoun R, Schumacher M, de Nicola AF.	2009	Glia	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	increase of number of oligodendrocyte precursor cells (NG2+/Ox42-cells) in the injured spinal cord					Systemic	Progesterone	Subcutaneous	16 mg/kg/day	6	6	5	Decrease	3 d	>=200, <300	>=300, <400			
19053058	19053058	Open PDF	Labombarda	Labombarda F, Gonz_lez SL, Lima A, Roig P, Guennoun R, Schumacher M, de Nicola AF.	2009	Glia	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Myelination	proteolipid protein expression and Olig1m transcription factor involved in myelin repair					Systemic	Progesterone	Subcutaneous	16 mg/kg/day	6	6	5	Increase	3 w	>=200, <300	>=300, <400			
19053058	19053058	Open PDF	Labombarda	Labombarda F, Gonz_lez SL, Lima A, Roig P, Guennoun R, Schumacher M, de Nicola AF.	2009	Glia	Positive	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Oligodendroglia	induction of differentiation into mature oligodendrocytes (increasing expression of Olig2 and Nkx2.2)					Systemic	Progesterone	Subcutaneous	16 mg/kg/day	6	6	5	Increase	3 d	>=200, <300	>=300, <400			
19053058	19053058	Open PDF	Labombarda	Labombarda F, Gonz_lez SL, Lima A, Roig P, Guennoun R, Schumacher M, de Nicola AF.	2009	Glia	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Male	250-300 g	Thoracic	Complete transection	Cell loss	increase of number of mature oligodendrocytes					Systemic	Progesterone	Subcutaneous	16 mg/kg/day	6	6	5	Decrease	3 w	>=200, <300	>=300, <400			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Neuronal regeneration	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Axonal regeneration	robust sprouting at the lesion site			Forceps		Local	Chondroitinase ABC	Intracerebroventricular infusion	6 _l of 10 U/ml	8	8	4	Increase		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Neuroprotection	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Cell loss	neuroprotection of corticospinal projection neurons			Forceps		Local	Chondroitinase ABC	Intracerebroventricular infusion	6 _l of 10 U/ml	8	8	4	Decrease		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Neuroprotection	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Cell loss	neuroprotection of corticospinal projection neurons			Forceps		Local	Chondroitinase ABC	Intrathecal	6 _l of 10 U/ml	8	8	4	Decrease		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Secondary degeneration	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Non-neuronal cells pathol.	cell atrophy			Forceps		Local	Chondroitinase ABC	Intracerebroventricular infusion	6 _l of 10 U/ml	8	8	4	Decrease		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Non-neuronal cell changes	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Glycosaminoglycans (chondroitin sulfate proteoglycans)	CSPG at site of injury			Forceps		Local	Chondroitinase ABC	Intrathecal	6 _l of 10 U/ml	8	8	4	Decrease		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Neuronal regeneration	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Axonal regeneration	robust sprouting at the lesion site			Forceps		Local	Chondroitinase ABC	Intrathecal	6 _l of 10 U/ml	8	8	4	Increase		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Secondary degeneration	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Non-neuronal cells pathol.	cell atrophy			Forceps		Local	Chondroitinase ABC	Intrathecal	6 _l of 10 U/ml	8	8	4	Decrease		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	Positive	Non-functional	Non-neuronal cell changes	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Glycosaminoglycans (chondroitin sulfate proteoglycans)	CSPG at site of injury			Forceps		Local	Chondroitinase ABC	Intracerebroventricular infusion	6 _l of 10 U/ml	8	8	4	Decrease		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	No effect	Non-functional	Molecular changes	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Enzyme activity	GSK-3__ expression or phosphorylation			Forceps		Local	Chondroitinase ABC	Intracerebroventricular infusion	6 _l of 10 U/ml	8	8	4	No change		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	No effect	Non-functional	Molecular changes	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Enzyme activity	GSK-3__ expression or phosphorylation			Forceps		Local	Chondroitinase ABC	Intrathecal	6 _l of 10 U/ml	8	8	4	No change		<100	<100			
19109493	19109493	Open PDF	Carter	Carter LM, Starkey ML, Akrimi SF, Davies M, McMahon SB, Bradbury EJ.	2008	J Neurosci	No effect	Non-functional	Molecular changes	Mouse	YFP-H	Adult	Male and female	20-25 g	Thoracic	Crush	Enzyme activity	PKC __II and Akt expression			Forceps		Local	Chondroitinase ABC	Intrathecal	6 _l of 10 U/ml	8	8	4	Increase		<100	<100			
19125588	19125588	Open PDF	Wang	Wang X, Budel S, Baughman K, Gould G, Song KH, Strittmatter SM.	2009	J Neurotrauma	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Female	250-270 g	Thoracic	Contusion	RhoA activation	twofold RhoA activation induced by injury			MASCIS impactor	10 g x 25 mm	Systemic	Ibuprofen	Subcutaneous	70 mg/kg/d	25	22		Decrease		>=200, <300	>=200, <300			
19125588	19125588	Open PDF	Wang	Wang X, Budel S, Baughman K, Gould G, Song KH, Strittmatter SM.	2009	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	250-270 g	Thoracic	Contusion	BBB	ibuprofen: 9,4 +/- 0,5; saline: 7,7 +/- 0,7; naproxen: 6,8 +/- 0,5  at 7w	9.4 [7.7]		MASCIS impactor	10 g x 25 mm	Systemic	Ibuprofen	Subcutaneous	70 mg/kg/d	25	22		Increase	7 w	>=200, <300	>=200, <300	49	9,4	7,7
19125588	19125588	Open PDF	Wang	Wang X, Budel S, Baughman K, Gould G, Song KH, Strittmatter SM.	2009	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	250-270 g	Thoracic	Contusion	Open field	rate of animals with hindlimb weight support			MASCIS impactor	10 g x 25 mm	Systemic	Ibuprofen	Subcutaneous	70 mg/kg/d	25	22		Increase	7 w	>=200, <300	>=200, <300			
19250688	19250688	Open PDF	Gris	Gris P, Tighe A, Thawer S, Hemphill A, Oatway M, Weaver L, Dekaban GA, Brown A.	2009	J Neuroimmunol	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Other	mediators that promote adaptive immune cell responses and wound healing			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Increase		>=200, <300	>=300, <400			
19250688	19250688	Open PDF	Gris	Gris P, Tighe A, Thawer S, Hemphill A, Oatway M, Weaver L, Dekaban GA, Brown A.	2009	J Neuroimmunol	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Apoptosis	TUNEL			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Decrease		>=200, <300	>=300, <400			
19250688	19250688	Open PDF	Gris	Gris P, Tighe A, Thawer S, Hemphill A, Oatway M, Weaver L, Dekaban GA, Brown A.	2009	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Pro-inflammatory Cytokine	pro-inflammatory cytokines (IL-6, IL-1_ and others)			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Decrease		>=200, <300	>=300, <400			
19250688	19250688	Open PDF	Gris	Gris P, Tighe A, Thawer S, Hemphill A, Oatway M, Weaver L, Dekaban GA, Brown A.	2009	J Neuroimmunol	Positive	Non-functional	Inflammation	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Inflammatory cells	hematogenous macrophage infiltration (CD8_ expression) [%]	65 [100]		Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Decrease		>=200, <300	>=300, <400		65	100
19250688	19250688	Open PDF	Gris	Gris P, Tighe A, Thawer S, Hemphill A, Oatway M, Weaver L, Dekaban GA, Brown A.	2009	J Neuroimmunol	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Female	250-300 g	Thoracic	Compression	Other	pro-survival, anti-apoptotic genes (Survivin, Selenium Glutathione Peroxidase, IGF-1)			Clip	50 g	Systemic	Anti-CD11d Antibody	Intravenous	1 mg/kg	n/a	n/a		Increase		>=200, <300	>=300, <400			
19291225	19291225	Open PDF	Freund	Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM.	2009	Eur J Neurosci	Positive	Non-functional	Secondary degeneration	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Lesion volume			Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	6		Decrease		>=500	>=500			
19291225	19291225	Open PDF	Freund	Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM.	2009	Eur J Neurosci	Positive	Functional	Locomotor test	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Manual Dexterity	recovery of manual dexterity (modified Brinkman board test, total number of pellets and contact time)		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	6		Increase		>=500	>=500			
19291225	19291225	Open PDF	Freund	Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM.	2009	Eur J Neurosci	Positive	Non-functional	Neuronal regeneration	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Axonal regeneration	normalized number of CS axons crossing midline at C5		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	6		Increase		>=500	>=500			
19291225	19291225	Open PDF	Freund	Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM.	2009	Eur J Neurosci	Positive	Non-functional	Neuronal regeneration	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Axonal regeneration	normalized number of axonal swellings caudal to the lesion		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	6		Increase		>=500	>=500			
19291225	19291225	Open PDF	Freund	Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM.	2009	Eur J Neurosci	Positive	Non-functional	Secondary degeneration	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Lesion volume			Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	6		Decrease		>=500	>=500			
19291225	19291225	Open PDF	Freund	Freund P, Schmidlin E, Wannier T, Bloch J, Mir A, Schwab ME, Rouiller EM.	2009	Eur J Neurosci	Positive	Functional	Locomotor test	Monkey	Macaque	Adult	Male and female	3-5 kg	Cervical	Partial transection	Manual Dexterity	complete recovery of function		Unilateral			Local	Anti-Nogo-A Antibody	Intrathecal	3,7-10 mg/ml	7	6		Increase	1 w	>=500	>=500			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Lesion volume				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	190 _mol/kg	n/a	n/a		Decrease		>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	BBB				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium			10	10		Increase		>=200, <300	>=200, <300	42	8,2	7,2
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Lesion volume				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium			10	10		Decrease		>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	BBB	improved locomotion was highly correlated with the lesion volume,with up to 4h delay; MgCl2: 10.0 +/- 0.2 vs Saline: 7.8 +/- 0.4			Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	190 _mol/kg	n/a	n/a		Increase		>=200, <300	>=200, <300	42	12	10
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Other				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	190 _mol/kg	n/a	n/a		Increase		>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Other				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	127 or 254 _mol/kg MgCl2	n/a	n/a		Increase		>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Lesion volume	lesion volume, relative to control [%]	67 [100]		Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	190 _mol/kg	n/a	n/a		Decrease		>=200, <300	>=200, <300		67	100
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	Positive	Non-functional	Neuroprotection	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Other				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium		127 or 254 _mol/kg MgCl2	5	n/a		Increase		>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Lesion volume				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	60 mg/kg	10	10		No change		>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Open field				Infinite Horizon Impactor	150 kdynes	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	10	10		No change	6 w	>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Lesion volume				Infinite Horizon Impactor	150 kdynes	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	10	10		No change	6 w	>=200, <300	>=200, <300			
19317592	19317592	Open PDF	Kwon	Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS.	2009	J Neurotrauma	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	200-225 g	Thoracic	Contusion	Lesion volume				Infinite Horizon Impactor	150 kdynes	Systemic	Magnesium	Intravenous	1 g/kg	10	10		No change		>=200, <300	>=200, <300			
19350644	19350644	Open PDF	Lo	Lo TP Jr, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD.	2009	J Comp Neurol	Positive	Functional	Locomotor test	Rat	Fischer	Adult	Female	180-200 g	Cervical	Contusion	Forelimb strength	weight-supported hanging and grip strength			OSU Impactor	Displacement of 0.95 mm	Systemic	Hypothermia		33_C	13	14	15	Increase		>=100, <200	>=200, <300			
19350644	19350644	Open PDF	Lo	Lo TP Jr, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD.	2009	J Comp Neurol	Positive	Non-functional	Secondary degeneration	Rat	Fischer	Adult	Female	180-200 g	Cervical	Contusion	Lesion volume	hypothermia spared gray and white matter			OSU Impactor	Displacement of 0.95 mm	Systemic	Hypothermia		33_C	13	14	15	Increase		>=100, <200	>=200, <300			
19350644	19350644	Open PDF	Lo	Lo TP Jr, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD.	2009	J Comp Neurol	Positive	Non-functional	Neuroprotection	Rat	Fischer	Adult	Female	180-200 g	Cervical	Contusion	Cell loss	decrease of loss of ventral motor neurons (NeuN+) 0,9-1,5 mm from epicenter but not in epicenter			OSU Impactor	Displacement of 0.95 mm	Systemic	Hypothermia		33_C	13	14	15	Decrease		>=100, <200	>=200, <300			
19350644	19350644	Open PDF	Lo	Lo TP Jr, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD.	2009	J Comp Neurol	Positive	Non-functional	Neuroprotection	Rat	Fischer	Adult	Female	180-200 g	Cervical	Contusion	Cell loss	loss of retrogradely traced neurons [%] significantly retarded	28.1[61.2]		OSU Impactor	Displacement of 0.95 mm	Systemic	Hypothermia		33_C	13	14	15	Decrease		>=100, <200	>=200, <300			
19350644	19350644	Open PDF	Lo	Lo TP Jr, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD.	2009	J Comp Neurol	Positive	Functional	Locomotor test	Rat	Fischer	Adult	Female	180-200 g	Cervical	Contusion	BBB	not at 8w PI			OSU Impactor	Displacement of 0.95 mm	Systemic	Hypothermia		33_C	13	14	15	Increase		>=100, <200	>=200, <300	77	11	11
19350644	19350644	Open PDF	Lo	Lo TP Jr, Cho KS, Garg MS, Lynch MP, Marcillo AE, Koivisto DL, Stagg M, Abril RM, Patel S, Dietrich WD, Pearse DD.	2009	J Comp Neurol	No effect	Functional	Locomotor test	Rat	Fischer	Adult	Female	180-200 g	Cervical	Contusion	Inclined plane test				OSU Impactor	Displacement of 0.95 mm	Systemic	Hypothermia		33_C	13	14	15	No change		>=100, <200	>=200, <300			
19368865	19368865	Open PDF	Kitzman	Kitzman PH.	2009	Neurosci Lett	Positive	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Complete transection	Spasticity			Through L1/2 laminectomy			Systemic	Riluzole	Intraperitoneal	8 mg/kg	4	4		Decrease		>=200, <300	>=200, <300			
19368865	19368865	Open PDF	Kitzman	Kitzman PH.	2009	Neurosci Lett	Positive	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Complete transection	Lethargy			Through L1/2 laminectomy			Systemic	Riluzole	Intraperitoneal	8 mg/kg	4	4		Decrease		>=200, <300	>=200, <300			
19368865	19368865	Open PDF	Kitzman	Kitzman PH.	2009	Neurosci Lett	Positive	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Complete transection	Spasticity			Through L1/2 laminectomy			Systemic	Riluzole	Intraperitoneal	10 mg/kg	4	4		Decrease		>=200, <300	>=200, <300			
19368865	19368865	Open PDF	Kitzman	Kitzman PH.	2009	Neurosci Lett	Positive	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Complete transection	Spasticity	ataxia		Through L1/2 laminectomy			Systemic	Riluzole	Intraperitoneal	8 mg/kg	4	4		Decrease		>=200, <300	>=200, <300			
19368865	19368865	Open PDF	Kitzman	Kitzman PH.	2009	Neurosci Lett	No effect	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Complete transection	Lethargy			Through L1/2 laminectomy			Systemic	Riluzole	Intraperitoneal	10 mg/kg	4	4		Increase		>=200, <300	>=200, <300			
19368865	19368865	Open PDF	Kitzman	Kitzman PH.	2009	Neurosci Lett	No effect	Functional	Physiology	Rat	SD	Adult	Female	200-250 g	Thoracic	Complete transection	Spasticity	ataxia		Through L1/2 laminectomy			Systemic	Riluzole	Intraperitoneal	10 mg/kg	4	4		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	serotonergic innervation of motoneurons		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	7	7		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	coordination		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Increase	9 w	>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	consistent step cycles		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Increase	9 w	>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	paw drag		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Decrease	9 w	>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	consistent step cycles		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Increase	9 w	>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	number of CST fibers		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	7	7		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	coordination		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Increase	9 w	>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	paw drag		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Decrease	9 w	>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	inclined gridwalk		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Walking analysis	inclined gridwalk		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	17	17		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	serotonergic innervation of motoneurons		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	7	7		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	number of CST fibers		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	7	7		Increase		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	nociceptive primary afferent fibers (CGRP+)		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	7	7		No change		>=200, <300	>=200, <300			
19372269	19372269	Open PDF	Maier	Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR, Schwab ME.	2009	Brain	No effect	Non-functional	Neuronal regeneration	Rat	SD	Adult	Female	200-250 g	Thoracic	Partial transection	Axonal regeneration	nociceptive primary afferent fibers (CGRP+)		T-shaped lesion (bilateral dorsal hemisection and complete midline transection)			Local	Anti-Nogo-A Antibody	Intrathecal	Ab: 3 mg/ml, 5 _l/h, 3,1 _g IgG/ml	7	7		No change		>=200, <300	>=200, <300			
19383246	19383246	Open PDF	Huang	Huang H, Fan S, Ji X, Zhang Y, Bao F, Zhang G.	2009	J Int Med Res	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	210 g	Thoracic	Contusion	Lesion volume	cavity volume			Weight drop	10 g x 50 mm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	20	20	20	Decrease		>=200, <300	>=200, <300			
19383246	19383246	Open PDF	Huang	Huang H, Fan S, Ji X, Zhang Y, Bao F, Zhang G.	2009	J Int Med Res	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	210 g	Thoracic	Contusion	Genetic transcription	phospho-extracellular signal-regulated kinase expression (p-ERK)			Weight drop	10 g x 50 mm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	20	20	20	Decrease	1 w	>=200, <300	>=200, <300			
19383246	19383246	Open PDF	Huang	Huang H, Fan S, Ji X, Zhang Y, Bao F, Zhang G.	2009	J Int Med Res	Positive	Functional	Locomotor test	Rat	SD	Adult	Male	210 g	Thoracic	Contusion	BBB		11 [9]		Weight drop	10 g x 50 mm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	20	20	20	Increase	1 w	>=200, <300	>=200, <300	7	11	9
19383246	19383246	Open PDF	Huang	Huang H, Fan S, Ji X, Zhang Y, Bao F, Zhang G.	2009	J Int Med Res	Positive	Non-functional	Neuronal regeneration	Rat	SD	Adult	Male	210 g	Thoracic	Contusion	Axonal regeneration	unspecific, H&E staining			Weight drop	10 g x 50 mm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	20	20	20	Increase		>=200, <300	>=200, <300			
19383246	19383246	Open PDF	Huang	Huang H, Fan S, Ji X, Zhang Y, Bao F, Zhang G.	2009	J Int Med Res	Positive	Non-functional	Molecular changes	Rat	SD	Adult	Male	210 g	Thoracic	Contusion	Genetic transcription	mitogen-activated protein kinase phosphatase-1 expression (MAPK-1)			Weight drop	10 g x 50 mm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	20	20	20	Increase	1 w	>=200, <300	>=200, <300			
19383246	19383246	Open PDF	Huang	Huang H, Fan S, Ji X, Zhang Y, Bao F, Zhang G.	2009	J Int Med Res	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Male	210 g	Thoracic	Contusion	Lesion volume	amount of spared tissue increased			Weight drop	10 g x 50 mm	Systemic	Erythropoietin	Intraperitoneal	1000 IU/kg	20	20	20	Decrease		>=200, <300	>=200, <300			
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	BBB		14 [10]		Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	6	6		Increase	4 w	>=200, <300	>=200, <300	28	14	10
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	apoptosis	TUNEL-positive cells at injury site			Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Apoptosis	caspase-3 activity in injured spinal cord			Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	6	6		Decrease		>=200, <300	>=200, <300			
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Apoptosis	caspase-3 activity in injured spinal cord			Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	8	11		Decrease		>=200, <300	>=200, <300			
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Apoptosis	TUNEL-positive cells at injury site			Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	8	11		Decrease		>=200, <300	>=200, <300			
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Lesion volume	spared tissue at injury site			Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	8	11		No change		>=200, <300	>=200, <300			
19429019	19429019	Open PDF	D_ry	D_ry MA, Rousseau G, Benderdour M, Beaumont E.	2009	Neurosci Lett	No effect	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	225-250 g	Thoracic	Contusion	Lesion volume	spared tissue at injury site [%]			Weight drop	5 g x 6 cm	Systemic	Atorvastatin (AT)	Intraperitoneal	5 mg/kg	6	6		No change		>=200, <300	>=200, <300			
19441987	19441987	Open PDF	Wiseman	Wiseman DB, Dailey AT, Lundin D, Zhou J, Lipson A, Falicov A, Shaffrey CI.	2009	J Neurosurg Spine	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	BBB		13.8 [8.6]		NYU impactor	10 g x 12.5 mm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	n/a	13		Increase		>=200, <300	>=300, <400	28	13,8	8,6
19441987	19441987	Open PDF	Wiseman	Wiseman DB, Dailey AT, Lundin D, Zhou J, Lipson A, Falicov A, Shaffrey CI.	2009	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Lesion volume	white matter sparing at injury site,MP: 30,3% white matter sparing, Saline: 20,2%			NYU impactor	10 g x 25 mm	Systemic	Magnesium	Intraperitoneal	30 mg/kg	17	13		Decrease		>=200, <300	>=300, <400			
19441987	19441987	Open PDF	Wiseman	Wiseman DB, Dailey AT, Lundin D, Zhou J, Lipson A, Falicov A, Shaffrey CI.	2009	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Lesion volume	white matter sparing at injury site,Mg: 32,3% white matter sparing, Saline: 20,2%			NYU impactor	10 g x 25 mm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	20	13		Decrease		>=200, <300	>=300, <400			
19441987	19441987	Open PDF	Wiseman	Wiseman DB, Dailey AT, Lundin D, Zhou J, Lipson A, Falicov A, Shaffrey CI.	2009	J Neurosurg Spine	Positive	Non-functional	Secondary degeneration	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	Lesion volume	white matter sparing at injury site,Mg + MP: 42,3% white matter sparing, Saline: 20,2%			NYU impactor	10 g x 25 mm	Systemic	Magnesium			20	13		Decrease		>=200, <300	>=300, <400			
19441987	19441987	Open PDF	Wiseman	Wiseman DB, Dailey AT, Lundin D, Zhou J, Lipson A, Falicov A, Shaffrey CI.	2009	J Neurosurg Spine	Positive	Functional	Locomotor test	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	BBB		6.9 [3.9]		NYU impactor	10 g x 25 mm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	20	13		Increase	4 w	>=200, <300	>=300, <400	28	6,9	3,9
19441987	19441987	Open PDF	Wiseman	Wiseman DB, Dailey AT, Lundin D, Zhou J, Lipson A, Falicov A, Shaffrey CI.	2009	J Neurosurg Spine	No effect	Functional	Locomotor test	Rat	SD	Adult	Female	250-300 g	Thoracic	Contusion	BBB				NYU impactor	10 g x 12.5 mm	Systemic	Magnesium	Intraperitoneal	600 mg/kg	n/a	13		No change		>=200, <300	>=300, <400	28	8	8,6
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	Positive	Non-functional	Neuronal regeneration	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Axonal regeneration	retrograde labelling of brainstem and cortical neurons with Fluorogold, applied caudal to lesion (T6/T7)	55.9 [33.8]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	12	10		Increase	7 w	>=200, <300	>=200, <300		55,9	33,8
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	Positive	Non-functional	Molecular changes	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Cytoskeletal integrity	preservation of dephosphorylated NF200  (Western Blot)	0.38 [0.24]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	3	3		Increase	1 d	>=200, <300	>=200, <300		0,38	0,24
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	Positive	Functional	Locomotor test	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	BBB		7.2 [4.5]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	12	11	9	Increase	6 w	>=200, <300	>=200, <300	42	7,2	4,5
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	Positive	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Lesion volume	Luxol fast blue staining of cross sections in lesion epicenter [%]	84.1 [67.7]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	12	10		Decrease	7 w	>=200, <300	>=200, <300		84,1	67,7
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	Positive	Non-functional	Neuroprotection	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Cell loss	increased NeuN cell count rostral to lesion, relative to Sham	0.46  [0.18]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	5	5	5	Decrease	1 w	>=200, <300	>=200, <300		0,46	0,18
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Apoptosis	TUNEL staining, number of apoptotic cells  in rostral spinal cord	41 [47]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	5	5	5	No change	1 w	>=200, <300	>=200, <300		41	47
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	No effect	Non-functional	Secondary degeneration	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Apoptosis	TUNEL staining, number of apoptotic cells  in caudal spinal cord	35 [55]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	5	5	5	No change	1 w	>=200, <300	>=200, <300		35	55
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	No effect	Non-functional	Non-neuronal cell changes	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Oligodendroglia	Oligodendroglia (APC positive) cell count rostral to lesion, relative to Sham	0.95  [0.90]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	5	5	5	No change	1 w	>=200, <300	>=200, <300		0,95	0,9
19458542	19458542	Open PDF	Baptiste	Baptiste DC, Austin JW, Zhao W, Nahirny A, Sugita S, Fehlings MG.	2009	J Neuropathol Exp Neurol	No effect	Functional	Locomotor test	Rat	Wistar	Adult	Female	200-250 g	Cervical	Compression	Inclined plane test	angle at which animals maintained at least 3 secon	40.0 [37.9]		Extradural Clip	35 g	Systemic	Polyethylene Glycol (PEG)	Intravenous	1 g/kg	12	11	9	No change	6 w	>=200, <300	>=200, <300		40	37,9
1010461440	DOI-Number		Yu, WR	Yu WR, Westergren H, Farooque M, Holtz A, Olsson Y	1999	Neuropathol	No effect	Non-functional	Non-neuronal cell changes	Rat	SD	Adult	Male	387 g	Thoracic	Compression	Astrogliosis	GFAP, semi-quantitative analysis around injury site				50g	Systemic	Hypothermia		30_C	5	5		Decrease		>=300, <400	>=300, <400