diff --git a/.chronus/changes/fix-model-base-docstrings-2026-7-8-14-9-0.md b/.chronus/changes/fix-model-base-docstrings-2026-7-8-14-9-0.md
new file mode 100644
index 00000000000..a4e55282507
--- /dev/null
+++ b/.chronus/changes/fix-model-base-docstrings-2026-7-8-14-9-0.md
@@ -0,0 +1,7 @@
+---
+changeKind: fix
+packages:
+  - "@typespec/http-client-python"
+---
+
+Clarify docstrings in the generated `_MyMutableMapping` base class in `_model_base.py` so they no longer use the ambiguous `D` placeholder (e.g. `Remove all items from D.` is now `Remove all items from the dictionary.`)
diff --git a/packages/http-client-python/generator/pygen/codegen/templates/model_base.py.jinja2 b/packages/http-client-python/generator/pygen/codegen/templates/model_base.py.jinja2
index e51a7645dde..54821400d89 100644
--- a/packages/http-client-python/generator/pygen/codegen/templates/model_base.py.jinja2
+++ b/packages/http-client-python/generator/pygen/codegen/templates/model_base.py.jinja2
@@ -470,21 +470,21 @@ class _MyMutableMapping(MutableMapping[str, typing.Any]):
 
     def keys(self) -> typing.KeysView[str]:
         """
-        :returns: a set-like object providing a view on D's keys
+        :returns: a set-like object providing a view on the mapping's keys
         :rtype: ~typing.KeysView
         """
         return self._data.keys()
 
     def values(self) -> typing.ValuesView[typing.Any]:
         """
-        :returns: an object providing a view on D's values
+        :returns: an object providing a view on the mapping's values
         :rtype: ~typing.ValuesView
         """
         return self._data.values()
 
     def items(self) -> typing.ItemsView[str, typing.Any]:
         """
-        :returns: set-like object providing a view on D's items
+        :returns: a set-like object providing a view on the mapping's items
         :rtype: ~typing.ItemsView
         """
         return self._data.items()
@@ -494,7 +494,7 @@ class _MyMutableMapping(MutableMapping[str, typing.Any]):
         Get the value for key if key is in the dictionary, else default.
         :param str key: The key to look up.
         :param any default: The value to return if key is not in the dictionary. Defaults to None
-        :returns: D[k] if k in D, else d.
+        :returns: The value for key if key is in the dictionary, else default.
         :rtype: any
         """
         try:
@@ -529,19 +529,19 @@ class _MyMutableMapping(MutableMapping[str, typing.Any]):
         Removes and returns some (key, value) pair
         :returns: The (key, value) pair.
         :rtype: tuple
-        :raises KeyError: if D is empty.
+        :raises KeyError: if the dictionary is empty.
         """
         return self._data.popitem()
 
     def clear(self) -> None:
         """
-        Remove all items from D.
+        Remove all items from the dictionary.
         """
         self._data.clear()
 
     def update(self, *args: typing.Any, **kwargs: typing.Any) -> None:  # pylint: disable=arguments-differ
         """
-        Updates D from mapping/iterable E and F.
+        Update the dictionary from a mapping or an iterable of key-value pairs.
         :param any args: Either a mapping object or an iterable of key-value pairs.
         """
         self._data.update(*args, **kwargs)
@@ -554,10 +554,11 @@ class _MyMutableMapping(MutableMapping[str, typing.Any]):
 
     def setdefault(self, key: str, default: typing.Any = _UNSET) -> typing.Any:
         """
-        Same as calling D.get(k, d), and setting D[k]=d if k not found
+        Return the value for key if key is in the dictionary; otherwise set the key to
+        default and return default.
         :param str key: The key to look up.
         :param any default: The value to set if key is not in the dictionary
-        :returns: D[k] if k in D, else d.
+        :returns: The value for key if key is in the dictionary, else default.
         :rtype: any
         """
         if default is _UNSET: