diff --git a/.github/workflows/code-style.yml b/.github/workflows/code-style.yml
index 41574a123c10..7c0bab5e5c19 100644
--- a/.github/workflows/code-style.yml
+++ b/.github/workflows/code-style.yml
@@ -21,9 +21,15 @@ jobs:
     steps:
       - if: github.event_name == 'push'
         uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v6
         with:
           python-version: "3.11"
+          activate-environment: true
+          enable-cache: true
+      - name: Check lock
+        id: check-lock
+        run: |
+          uv lock --check
       - run: |
           bash ./tests/run_code_style.sh install
           bash ./tests/run_code_style.sh fmt
diff --git a/.github/workflows/docs.yml b/.github/workflows/docs.yml
index b9f95c3cc7d2..c475a4e0f6c6 100644
--- a/.github/workflows/docs.yml
+++ b/.github/workflows/docs.yml
@@ -20,15 +20,17 @@ jobs:
     runs-on: ubuntu-latest
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v6
         with:
           python-version: "3.10"
+          activate-environment: true
+          enable-cache: true
 
       - run: sudo npm install katex -g
-      - uses: actions/cache@v4
-        with:
-          path: ~/.cache/pip
-          key: pip-${{ hashFiles('requirements-dev.txt') }}-${{ hashFiles('docs/requirements.txt') }}
+      # - uses: actions/cache@v4
+      #   with:
+      #     path: ~/.cache/pip
+      #     key: pip-${{ hashFiles('requirements-dev.txt') }}-${{ hashFiles('docs/requirements.txt') }}
 
       - name: Install docs deps
         run: bash .github/workflows/install_docs_deps.sh
@@ -51,14 +53,16 @@ jobs:
     timeout-minutes: 10
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v6
         with:
           python-version: "3.10"
+          activate-environment: true
+          enable-cache: true
 
-      - uses: actions/cache@v4
-        with:
-          path: ~/.cache/pip
-          key: pip-${{ hashFiles('requirements-dev.txt') }}-${{ hashFiles('docs/requirements.txt') }}
+      # - uses: actions/cache@v4
+      #   with:
+      #     path: ~/.cache/pip
+      #     key: pip-${{ hashFiles('requirements-dev.txt') }}-${{ hashFiles('docs/requirements.txt') }}
 
       - name: Install docs deps
         run: bash .github/workflows/install_docs_deps.sh
@@ -72,15 +76,23 @@ jobs:
     runs-on: ubuntu-latest
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+
+      - uses: astral-sh/setup-uv@v6
         with:
           python-version: "3.10"
+          activate-environment: true
+          enable-cache: true
+
+      - name: Check lock
+        id: check-lock
+        run: |
+          uv lock --check
 
       - run: sudo npm install katex -g
-      - uses: actions/cache@v4
-        with:
-          path: ~/.cache/pip
-          key: pip-${{ hashFiles('requirements-dev.txt') }}-${{ hashFiles('docs/requirements.txt') }}
+      # - uses: actions/cache@v4
+      #   with:
+      #     path: ~/.cache/pip
+      #     key: pip-${{ hashFiles('requirements-dev.txt') }}-${{ hashFiles('docs/requirements.txt') }}
 
       - name: Install docs deps
         run: bash .github/workflows/install_docs_deps.sh
diff --git a/.github/workflows/hvd-tests.yml b/.github/workflows/hvd-tests.yml
index efa73425549e..da7d29aec369 100644
--- a/.github/workflows/hvd-tests.yml
+++ b/.github/workflows/hvd-tests.yml
@@ -41,29 +41,36 @@ jobs:
 
       - name: Get pip cache dir
         id: pip-cache
+        shell: bash -l {0}
         run: |
-          python3 -m pip install -U pip
+          uv pip install -U pip
           echo "pip_cache=$(python3 -m pip cache dir)" >> $GITHUB_OUTPUT
-        shell: bash -l {0}
 
-      - uses: actions/cache@v4
-        with:
-          path: |
-            ~/conda_pkgs_dir
-            ${{ steps.pip-cache.outputs.pip_cache }}
-          key: ${{ steps.get-date.outputs.date }}-horovod-${{ hashFiles('requirements-dev.txt') }}
+      # - uses: actions/cache@v4
+      #   with:
+      #     path: |
+      #       ~/conda_pkgs_dir
+      #       ${{ steps.pip-cache.outputs.pip_cache }}
+      #     key: ${{ steps.get-date.outputs.date }}-horovod-${{ hashFiles('requirements-dev.txt') }}
 
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v6
         with:
           python-version: ${{ matrix.python-version }}
+          activate-environment: true
+          enable-cache: true
 
+      - name: Check lock
+        id: check-lock
+        run: |
+          uv lock --check
+      
       - name: Install dependencies
         shell: bash -l {0}
         run: |
 
-          #install other dependencies
-          pip install torch torchvision --index-url https://download.pytorch.org/whl/cpu
-          pip install -r requirements-dev.txt
+          # install other dependencies
+          uv pip install torch torchvision --index-url https://download.pytorch.org/whl/cpu
+          uv pip install -r requirements-dev.txt
 
           # Install Horovod from source and apply a patch to build with recent pytorch
           # We can't use pip install <whatever> as build-env can't find pytorch and
@@ -78,7 +85,7 @@ jobs:
           python -c "import horovod.torch as hvd; hvd.mpi_ops.Sum"
 
           # Install ignite
-          pip install .
+          uv pip install .
 
       # Download MNIST: https://github.com/pytorch/ignite/issues/1737
       # to "/tmp" for cpu tests
diff --git a/.github/workflows/install_docs_deps.sh b/.github/workflows/install_docs_deps.sh
index 499b64211943..0beaca31288b 100644
--- a/.github/workflows/install_docs_deps.sh
+++ b/.github/workflows/install_docs_deps.sh
@@ -1,6 +1,6 @@
 # remove pkg-resources as it causes failure when installing https://github.com/pytorch-ignite/sphinxcontrib-versioning
-pip uninstall -y pkg-resources setuptools && pip install --upgrade setuptools pip wheel
-pip install torch torchvision --index-url https://download.pytorch.org/whl/cpu -U
-pip install -r requirements-dev.txt
-pip install -r docs/requirements.txt
-pip install git+https://github.com/pytorch-ignite/sphinxcontrib-versioning.git
+uv pip uninstall pkg-resources setuptools && pip install --upgrade setuptools pip wheel
+uv pip install torch torchvision --index-url https://download.pytorch.org/whl/cpu -U
+uv pip install -r requirements-dev.txt
+uv pip install -r docs/requirements.txt
+uv pip install git+https://github.com/pytorch-ignite/sphinxcontrib-versioning.git
diff --git a/.github/workflows/tpu-tests.yml b/.github/workflows/tpu-tests.yml
index 2bd5e8f0d2c0..b4fb39ea4224 100644
--- a/.github/workflows/tpu-tests.yml
+++ b/.github/workflows/tpu-tests.yml
@@ -36,49 +36,51 @@ jobs:
 
     steps:
       - uses: actions/checkout@v4
+
       - name: Set up Python 3.10
-        uses: actions/setup-python@v5
+        uses: astral-sh/setup-uv@v6
         with:
           python-version: "3.10"
-          architecture: "x64"
+          activate-environment: true
+          enable-cache: true
+
+      - name: Check lock
+        id: check-lock
+        run: |
+          uv lock --check
 
       - name: Get year & week number
         id: get-date
-        run: echo "date=$(/bin/date "+%Y-%U")" >> $GITHUB_OUTPUT
         shell: bash -l {0}
+        run: echo "date=$(/bin/date "+%Y-%U")" >> $GITHUB_OUTPUT
 
       - name: Get pip cache dir
         id: pip-cache
+        shell: bash -l {0}
         run: |
-          pip3 install -U "pip<24"
+          uv pip install -U "pip<24"
           echo "pip_cache=$(pip cache dir)" >> $GITHUB_OUTPUT
-        shell: bash -l {0}
-
-      - uses: actions/cache@v4
-        with:
-          path: |
-            ${{ steps.pip-cache.outputs.pip_cache }}
-          key: ${{ steps.get-date.outputs.date }}-pytorch-${{ runner.os }}-${{ matrix.xla-version }}-${{ hashFiles('requirements-dev.txt') }}
-          restore-keys: |
-            ${{ steps.get-date.outputs.date }}-pytorch-${{ runner.os }}-${{ matrix.xla-version }}-
 
       - name: Install Torch XLA and others
         run: |
 
           ## Install mkl (alternative approach to https://github.com/pytorch/xla/blob/b0ba29f98a695671972d4a4cc07441014dba2892/.kokoro/common.sh#L31-L32)
           sudo apt-get update && sudo apt-get install -y libopenblas-dev libomp5
-          pip install mkl==2021.4.0
+          uv pip install mkl==2021.4.0
 
           ## Install torch & xla and torchvision
-          pip install --pre torch torchvision --index-url https://download.pytorch.org/whl/nightly/cpu
-          pip install https://storage.googleapis.com/pytorch-xla-releases/wheels/tpuvm/torch_xla-nightly-cp310-cp310-linux_x86_64.whl
+          uv pip install --pre torch torchvision --index-url https://download.pytorch.org/whl/nightly/cpu
+          ## TODO: download file and rename as valid file with version
+          curl -o torch_xla-2.5.0+gitf0bbaeb-cp310-cp310-linux_x86_64.whl https://storage.googleapis.com/pytorch-xla-releases/wheels/tpuvm/torch_xla-nightly-cp310-cp310-linux_x86_64.whl
+          uv pip install torch_xla-2.5.0+gitf0bbaeb-cp310-cp310-linux_x86_64.whl
+          # uv pip install https://storage.googleapis.com/pytorch-xla-releases/wheels/tpuvm/torch_xla-nightly-cp310-cp310-linux_x86_64.whl
 
           # Check installation
           python -c "import torch"
 
           ## Install test deps and Ignite
-          pip install -r requirements-dev.txt
-          pip install .
+          uv pip install -r requirements-dev.txt
+          uv pip install .
 
       # Download MNIST: https://github.com/pytorch/ignite/issues/1737
       # to "/tmp" for tpu tests
diff --git a/.github/workflows/unit-tests.yml b/.github/workflows/unit-tests.yml
index c3d0b621e03e..7585a50d006b 100644
--- a/.github/workflows/unit-tests.yml
+++ b/.github/workflows/unit-tests.yml
@@ -59,9 +59,11 @@ jobs:
 
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v6
         with:
           python-version: ${{ matrix.python-version }}
+          activate-environment: true
+          enable-cache: true
 
       - name: Get year & week number
         id: get-date
@@ -82,21 +84,21 @@ jobs:
           restore-keys: |
             ${{ steps.get-date.outputs.date }}-pytorch-${{ runner.os }}-${{ matrix.python-version }}-${{ matrix.pytorch-channel }}-
 
-      - run: pip install pip wheel setuptools -Uqq
+      - run: uv pip install pip wheel setuptools -Uqq
 
       - name: Install PyTorch
         if: ${{ matrix.pytorch-channel == 'pytorch' }}
-        run: pip install torch torchvision --index-url https://download.pytorch.org/whl/cpu
+        run: uv pip install torch torchvision --index-url https://download.pytorch.org/whl/cpu
 
       - name: Install PyTorch (nightly)
         if: ${{ matrix.pytorch-channel == 'pytorch-nightly' }}
-        run: pip install torch torchvision --index-url https://download.pytorch.org/whl/nightly/cpu --pre
+        run: uv pip install torch torchvision --index-url https://download.pytorch.org/whl/nightly/cpu --pre
 
       - name: Install dependencies
         run: |
-          pip install -r requirements-dev.txt
-          pip install .
-          pip list
+          uv pip install -r requirements-dev.txt
+          uv pip install .
+          uv pip list
 
       - name: Check code formatting
         run: |
@@ -156,7 +158,7 @@ jobs:
           # 3.1) mnist_with_tensorboard.py with tbX
           python examples/mnist/mnist_with_tensorboard.py --epochs=1
           # 3.2) mnist_with_tensorboard.py with native torch tb
-          pip uninstall -y tensorboardX
+          uv pip uninstall tensorboardX
           python examples/mnist/mnist_with_tensorboard.py --epochs=1
 
       - name: Run MNIST Example With Crash
diff --git a/docs/requirements.txt b/docs/requirements.txt
index 9a88587a0ee2..8723edbff733 100644
--- a/docs/requirements.txt
+++ b/docs/requirements.txt
@@ -1,5 +1,5 @@
 sphinx<6
--e git+https://github.com/pytorch/pytorch_sphinx_theme.git#egg=pytorch_sphinx_theme
+git+https://github.com/pytorch/pytorch_sphinx_theme.git#egg=pytorch_sphinx_theme
 sphinxcontrib-katex
 sphinx-copybutton==0.4.0
 docutils<0.18
diff --git a/pyproject.toml b/pyproject.toml
index 1c60c561bafb..d01319b6f56f 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -14,6 +14,7 @@ license-files = ["LICENSE"]
 classifiers = [
     "Programming Language :: Python :: 3",
 ]
+requires-python = ">=3.9,<3.13"
 dependencies = [
     "torch>=1.3,<3",
     "packaging"
diff --git a/tests/run_code_style.sh b/tests/run_code_style.sh
index e94a652fbeb9..fe744ff1869e 100755
--- a/tests/run_code_style.sh
+++ b/tests/run_code_style.sh
@@ -3,12 +3,12 @@
 set -xeu
 
 if [ $1 = "lint" ]; then
-    flake8 ignite tests examples --config setup.cfg
-    ufmt diff .
+    uv run flake8 ignite tests examples --config setup.cfg
+    uv run ufmt diff .
 elif [ $1 = "fmt" ]; then
-    ufmt format .
+    uv run ufmt format .
 elif [ $1 = "mypy" ]; then
-    mypy --config-file mypy.ini
+    uv run mypy --config-file mypy.ini
 elif [ $1 = "install" ]; then
-    pip install --upgrade flake8 "black==24.10.0" "usort==1.0.8.post1" "ufmt==2.7.3" "mypy"
+    uv pip install --upgrade flake8 "black==24.10.0" "usort==1.0.8.post1" "ufmt==2.7.3" "mypy"
 fi