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minor updates to tutorials and Readme
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README.md

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# Predicting regional mutation burden in cancer genomes using chromatin accessibility (CA) and replication timing (RT)
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This repository includes source code and processed datasets for the study:
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This repository includes source code, tutorials, and processed datasets for the study:
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_Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin_ .
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* 3_CA2M_RF.ipynb - random forest models of megabase-scale mutation burden, chromatin accessibility and replication timing
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* 4_CA2M_RF_FeatureSelection_Tutorial.ipynb - selecting significant features predicting mutation rates
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* 5_CA2M_RF_SHAPscores.ipynb - computing feature importance scores (SHAP)
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* 6_CA2M_RF_ExcessMutations_Tutorial.ipynb - detecting genomic regions with enriched mutations not explained by chromatin and replication timing alone
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* 6_CA2M_RF_EnrichedMutations_Tutorial.ipynb - detecting genomic regions with enriched mutations that are not explained by chromatin and replication timing alone
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Tutorials/data - files needed for tutorials
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All_code - entire code repository for the project; use on your own responsibility
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oliver.ocsenas [@] gmail.com ; juri.reimand [@] utoronto.ca
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Contact: oliver.ocsenas [@] gmail.com ; juri.reimand [@] utoronto.ca
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Tutorials/3_CA2M_RF.ipynb

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Tutorials/6_CA2M_RF_ExcessMutations_Tutorial.ipynb Tutorials/6_CA2M_RF_EnrichedMutations_Tutorial.ipynb

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"Now we have p-values for every megabase-scale window in our analysis that describes excess mutations in the breast cancer cohort in relation to our model predictions. We can display the top 5 genomic regions with excess mutations."
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"Now we have p-values for every megabase-scale window in our analysis that describes enriched mutations in the breast cancer cohort in relation to our model predictions. We can display the top 5 genomic regions with enriched mutations."
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"Now we have a p-value for excess mutations for each of our genomic windows which allows us to do further analysis as to why these genomic regions contain excess mutations."
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"Now we have a p-value for enriched mutations for each of our genomic windows which allows us to do further analysis as to why these genomic regions contain enriched mutations."
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