diff --git a/src/scilpy/cli/scil_labels_from_mask.py b/src/scilpy/cli/scil_labels_from_mask.py
index 6991b254f..bb172d786 100755
--- a/src/scilpy/cli/scil_labels_from_mask.py
+++ b/src/scilpy/cli/scil_labels_from_mask.py
@@ -38,6 +38,9 @@ def _build_arg_parser():
     p.add_argument('--min_volume', type=float, default=7,
                    help='Minimum volume in mm3 [%(default)s],'
                         'Useful for lesions.')
+    p.add_argument('--min_distance', type=int, default=None,
+                   help='Minimum distance in voxels [%(default)s],'
+                        'Useful for confluent lesions.')
 
     add_verbose_arg(p)
     add_overwrite_arg(p)
@@ -57,11 +60,13 @@ def main():
     mask_data = get_data_as_mask(mask_img)
     voxel_volume = np.prod(np.diag(mask_img.affine)[:3])
     min_voxel_count = args.min_volume // voxel_volume
+    min_distance = args.min_distance
 
     # Get labels from mask
     label_map = get_labels_from_mask(
         mask_data, args.labels, args.background_label,
-        min_voxel_count=min_voxel_count)
+        min_voxel_count=min_voxel_count,
+        min_distance=min_distance)
     # Save result
     out_img = nib.Nifti1Image(label_map.astype(np.uint16), mask_img.affine)
     nib.save(out_img, args.out_labels)
diff --git a/src/scilpy/image/labels.py b/src/scilpy/image/labels.py
index 60c09ad2c..e8d1292c2 100644
--- a/src/scilpy/image/labels.py
+++ b/src/scilpy/image/labels.py
@@ -8,6 +8,8 @@
 import numpy as np
 from scipy import ndimage as ndi
 from scipy.spatial import cKDTree
+from skimage.segmentation import watershed
+from skimage.feature import peak_local_max
 
 from scilpy.tractanalysis.reproducibility_measures import compute_bundle_adjacency_voxel
 
@@ -72,7 +74,7 @@ def get_binary_mask_from_labels(atlas, label_list):
 
 
 def get_labels_from_mask(mask_data, labels=None, background_label=0,
-                         min_voxel_count=0):
+                         min_voxel_count=0, min_distance=0):
     """
     Get labels from a binary mask which contains multiple blobs. Each blob
     will be assigned a label, by default starting from 1. Background will
@@ -90,6 +92,11 @@ def get_labels_from_mask(mask_data, labels=None, background_label=0,
     min_voxel_count: int, optional
         Minimum number of voxels for a blob to be considered. Blobs with fewer
         voxels will be ignored.
+    min_distance : int, optional
+        The minimum voxels separating the peaks of two 
+        neighboring blobs. If a confluent blob is detected, it will be 
+        split into multiple labels based on this distance. If None, no 
+        splitting is performed.
 
     Returns
     -------
@@ -97,7 +104,22 @@ def get_labels_from_mask(mask_data, labels=None, background_label=0,
         The labels.
     """
     # Get the number of structures and assign labels to each blob
-    label_map, nb_structures = ndi.label(mask_data)
+    if min_distance:
+        distance = ndi.distance_transform_edt(mask_data)
+        coords = peak_local_max(
+            distance,
+            min_distance=min_distance,
+            labels=mask_data,
+            threshold_abs=0
+        )
+        mask = np.zeros(distance.shape, dtype=bool)
+        mask[tuple(coords.T)] = True
+        markers, _ = ndi.label(mask)
+        label_map = watershed(-distance, markers, mask=mask_data)
+        nb_structures = np.max(label_map)
+    else:
+        label_map, nb_structures = ndi.label(mask_data)
+
     if min_voxel_count:
         new_count = 0
         for label in range(1, nb_structures + 1):