Make Bertozzi consistent

[stephanmg]

Make Bertozzi's Susceptible_to_Infected consistent.

[dilpath]

What is inconsistent? The Susceptible -> Infected reaction is not reversible, right?

[stephanmg]

Susceptible_to_Infected
Rate Law for Susceptible_to_Infected_1
The kinetic function is marked as irreversible but at least one of its variables is labeled as product. 

[dilpath]

Is this forbidden in SBML? The interaction between susceptible + infected causes susceptible -> infected, not infected -> susceptible, right?

[stephanmg]

Is this forbidden in SBML? The interaction between susceptible + infected causes susceptible -> infected, not infected -> susceptible, right?

Ah, the interaction should be non-reversible true. So what about this message from COPASI/SBML validator? False-positive warning?

[dilpath]

False-positive warning?

I'm not sure, but this is my guess -- maybe it's unusual to see direct positive-feedback with the product in the kinetic law.

[FFroehlich]

I think the rate law should be susceptible + infected -> infected + infected rather than susceptible -> infected

[dilpath]

I think the rate law should be susceptible + infected -> infected + infected rather than susceptible -> infected

Ah thanks, makes sense, done in #222 , where the problem is further modified to be a more reasonable parameter estimation problem.

[stephanmg]

Can this issue then be closed in light of additional fixes in #222?