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Human Lung Development Atlas (HLDA)

Samuel H. Kim, Soon Il Higashino, Lea C. Steffes, Li Li, Anca M. Pasca, Maya E. Kumar, Christin S. Kuo, Mark A. Krasnow, William J. Greenleaf

This repository contains code used for the analysis of the single cell multiomic atlas of human lung development. Please review the manuscript and the data repository below for further information. Data repository on Zenodo includes preprocessed RNA and ATAC data (ATAC fragment files, filtered RNA feature count matrices), R data objects (ArchR Projects, Seurat Objects), and ChromBPNet files (models, contribution scores, and bigwig files).

If you use the code or data in this repository, please consider citing:

Chromatin and gene-regulatory dynamics of human pulmogenesis by single cell multiomic sequencing. Samuel H. Kim, Soon Il Higashino, Lea C. Steffes, Li Li, Anca M. Pasca, Maya E. Kumar, Christin S. Kuo, Mark A. Krasnow, William J. Greenleaf, bioRxiv 2025.09.24.678382; doi:https://doi.org/10.1101/2025.09.24.678382

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