Welcome to the Structural Mechanobiology Lab's GitHub organization. Our lab, led by Dr. Shubhasis Haldar, is dedicated to unraveling the complexities of force-regulated biological phenomena, which are fundamental to various pathophysiological conditions.
We employ a multidisciplinary approach, integrating traditional cell biology, state-of-the-art nanoscopy, machine learning, and advanced computational biology to explore:
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Mechanical Roles of Chaperone-Assisted Protein Folding: Investigating how chaperones influence protein folding under mechanical stress.
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Mechanosensitive Proteins in Focal Adhesion-Mediated Cellular Processes: Studying the role of mechanosensitive proteins in cellular adhesion and migration.
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Developmental Mechanobiology and Cancer Intersection: Exploring how mechanical forces influence tissue development and their implications in cancer.
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Regulation of Protein Mechanics by Small Molecule Drugs and Microenvironment: Examining how drugs and the cellular environment affect protein mechanical properties.
For detailed information on our research themes, please visit our Research Page.
Our work has been featured in several peer-reviewed journals. For a comprehensive list of our publications, please refer to our Publications Page.
Our lab comprises a diverse group of scientists and researchers. Learn more about our team on our Scientists Page.
We are currently accepting applications for a PhD position for the January 2025 session. Interested candidates with valid CSIR/UGC-NET JRF in Biology or Chemistry should notify us via email and apply through the S.N. Bose National Centre for Basic Sciences website.
For inquiries or collaboration opportunities, please visit our Contact Page.
Our research is generously funded by the following organizations:
For more information about our lab and ongoing projects, please visit our official website.
