Paralytic use across CLIF consortium*

CLIF VERSION

2.1

Objective

To describe variability in paralytic use across the CLIF consortium with a focus on patients who meet ROSE trial hypoxemia criteria.

Required CLIF tables and fields

Example: The following tables are required:

1. patient: patient_id, race_category, ethnicity_category, sex_category
2. hospitalization: patient_id, hospitalization_id, admission_dttm, discharge_dttm, age_at_admission
3. vitals: hospitalization_id, recorded_dttm, vital_category, vital_value
   • vital_category = 'heart_rate', 'resp_rate', 'map', 'resp_rate', 'spo2'
4. labs: hospitalization_id, lab_result_dttm, lab_category, lab_value
   • lab_category = 'lactate, ph_arterial, ph_venous, bilirubin, creatinine, po2_arterial'
5. medication_admin_continuous: hospitalization_id, admin_dttm, med_name, med_category, med_dose, med_dose_unit
   • med_category = "norepinephrine", "epinephrine", "phenylephrine", "vasopressin", "dopamine", "angiotensin", "cisatracurium", "vecuronium", "rocuronium"
6. medication_admin_intermittent: hospitalization_id, admin_dttm, med_name, med_category, med_dose, med_dose_unit
   • med_category = "cisatracurium", "vecuronium", "rocuronium", "succinylcholine"
7. respiratory_support: hospitalization_id, recorded_dttm, device_category, mode_category, tracheostomy, fio2_set, lpm_set, resp_rate_set, peep_set, resp_rate_obs, 'peak_inspiratory_pressure_obs', 'minute_vent_obs', 'plateau_pressure_obs'

Cohort identification

Patients on invasive mechanical ventilation, with primary outcome cohort restricted to patients who meet criteria based on ROSE RCT inclusion and exclusion criteria: No chronic mechanical ventilation (trach within 24h of intubation), PEEP >=8, P/F (or equivalent S/F x2) <=150. Excludes patients who transfer from hospital outside of health system while already receiving IMV.

Expected Results

18 csv files and 9 pdf figures, saves in project_output folder (in path input by site PI at beginning of 01 file)

Detailed Instructions for running the project

Detailed instructions on the code workflow are provided in the code directory

** NOTE: For this project, there is no config file to update. Provide your time zone and paths to local data directly in the 00 and 01 files.

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