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New alerts in final report #186

Merged
merged 5 commits into from
Sep 16, 2024
Merged

New alerts in final report #186

merged 5 commits into from
Sep 16, 2024

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standage
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@standage standage commented Sep 16, 2024

In #183, MicroHapulator was updated to mark gap alleles as - instead of leaving them empty, causing the read to be discarded. This allows the user to distinguish between SNPs that are not covered by the read and SNPs that are covered by the read but have an alignment gap. The prevalence of reads with gaps can elucidate the presence of indel variants.

In this PR, two new tables are added to report potentially problematic markers. Table 4.3 shows markers that have a high proportion of aligned reads (default >25%) that don't span all SNPs. Table 4.4 shows markers with a high proportion of reads (default >5%) containing alignment gaps. The presence of either such artifact is important for troubleshooting the success of a sequencing run and the analysis and interpretation of a typing result.

Closes #184.


@standage standage merged commit 5a91885 into main Sep 16, 2024
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@standage standage deleted the alerts branch September 16, 2024 15:25
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