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scArches#404

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sf-scarches
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scArches#404
sjfleming wants to merge 2 commits into
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sf-scarches

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@sjfleming

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Implement scArches (https://www.nature.com/articles/s41587-021-01001-7)

This would allow CAS, for example, to do a quick, minimal re-training step with only user query data, in order to align query data with a reference.

Note however, according to me and verified by Gemini:

If your encoder does not receive batch information, scArches will do absolutely nothing to improve your query's latent embedding.

In the CAS context, this means we would need to train an scVI model with batch included in the encoder, and then fine-tune using scArches on the query data from a user.

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