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scvi: add normalizetotal option to encoder preprocessing#412

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sjfleming merged 2 commits into
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sf-scvi-normalizetotal-pre-encoder
Jul 17, 2026
Merged

scvi: add normalizetotal option to encoder preprocessing#412
sjfleming merged 2 commits into
mainfrom
sf-scvi-normalizetotal-pre-encoder

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Closes #410

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Setting normalizetotal_variational=True and running the demo scVI notebook produces a very nice looking result for the PBMC demo dataset

image

Certainly does not seem to hurt, as an option.

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sjfleming requested a review from fedorgrab July 16, 2026 19:09

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lgmt, excited to try it out and benchmark!

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sjfleming merged commit 6564746 into main Jul 17, 2026
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sjfleming deleted the sf-scvi-normalizetotal-pre-encoder branch July 17, 2026 15:36
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scvi: optional library size norm pre-encoder

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