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Alignment should be done on full assembly not shards#111

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miraep8 wants to merge 7 commits into
mainfrom
fix_annotation_alignment
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Alignment should be done on full assembly not shards#111
miraep8 wants to merge 7 commits into
mainfrom
fix_annotation_alignment

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@miraep8
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@miraep8 miraep8 commented Oct 14, 2025

Realized that we were performing alignment on each shard, rather than on the full assembly. Given that some Cazyme genes may be somewhat degenerate, I am concerned that this may be causing us to over-inflate our RPM estimates. Will test a few samples with isabl before this is ready for merging.

@nickp60
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nickp60 commented Oct 15, 2025

Interesting! Well whether it changes the results or not, it should run markedly faster!

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miraep8 commented Feb 13, 2026

Moving to archive this PR in favor of funcscan.

@miraep8 miraep8 closed this Feb 13, 2026
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