aging mitochondria

Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

Biological age is increased by stress and restored upon recovery

• the stress is carved in epigenomics

Biological age is increased by stress and restored upon recovery

• parabiosis
• DNAm clocks (DNAmPhenoAge,14 DNAmGrimAge,15 and DunedinPACE17

Identification and application of gene expression signatures associated with lifespan extension

• Gene expression signatures of aging[23] (https://www.sciencedirect.com/science/article/pii/S1550413123000931?via%3Dihub&fbclid=IwAR1_VLGvxeW5v-W8xc-1dsE1fiWlyAitq__Evrr9smBtCqDVpvgmquqaunQ#bib23)

Dongryeol Ryu, NatComm, 2022, L-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans

Role of Ferroptosis in Lung Diseases

A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations