structural immunity

non-haematopoietic (epithelium, endothelium and fibroblasts) immuninity. "Structural cells were purified with an organ-independent sorting scheme that comprised the endothelium marker CD31 (encoded by Pecam1), the epithelium marker EpCAM (Epcam) and the fibroblast marker GP38 (encoded by Pdpn, also known as podoplanin) (Extended Data Fig. 1a, b). For example, strong expression of collagens (Col4a3, Col4a4, Col5a1, Col6a1 and Col12a1) and of complement component 3 (C3) in fibroblasts is expected to enhance their ability to interact with haematopoietic cells; high levels of Muc2 and Arg2 in the digestive tract fosters interactions with macrophages and natural killer cells; and Ccl25 expression in thymus epithelium contributes to the maturation of T cells. Shared across all types of structural cells, we observed high expression of the inflammatory mediators Apoe, S100a8 and S100a9. Cdh16 was exclusively open in kidney. By contrast, a subset of crucial immune genes (exemplified by Ifngr1) showed high chromatin accessibility in most samples, indicative of a shared core of immune regulation in structural cells. For example, ATF, ELK, ETS and JUND were most active in lung endothelium; KLF and CDX in digestive tract epithelium; and HNF in kidney fibroblasts and in epithelium of caecum, large intestine and small intestine." https://www.nature.com/articles/s41586-020-2424-4

database https://www.nature.com/articles/s41577-020-0398-y

cell-to-cellhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649713/