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spatial single cell models

Hyunmin Kim edited this page Dec 13, 2023 · 4 revisions

Point Pattern Analysis

https://www.mattpeeples.net/modules/PointPattern.html

Labs

WangLab

image

Review

Methods and applications for single-cell and spatial multi-omics

Cell Models

In silico tissue generation and power analysis for spatial omics

Integrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope $$log p ({{{{{{{{\bf{X}}}}}}}}}^{(t)} {{{{{{{\bf{y}}}}}}}},, {k}{1},, {k}{2}),=,\log p({{{{{{{\bf{y}}}}}}}}{{{{{{{{\bf{X}}}}}}}}}^{(t)},, {k}{1},, {k}{2}),+\log p({{{{{{{{\bf{x}}}}}}}}}{1}^{(t)}{k}{1})+\logp({{{{{{{{\bf{x}}}}}}}}}{2}^{(t)}| {k}{2})-\log p({{{{{{{\bf{y}}}}}}}} {k}{1},, {k}{2}}$$

Database

SODB facilitates comprehensive exploration of spatial omics data

imputation and QC

Zero-preserving imputation of single-cell RNA-seq data

ambient RNA remover , https://github.com/marcalva/diem

Epi-Spatial

Spatially resolved epigenomic profiling of single cells in complex tissues

Gene Regulatory Model (GRM)

The adapted Activity-By-Contact model for enhancer-gene assignment and its application to single-cell data https://www.biorxiv.org/content/10.1101/2022.01.28.478202v2.full.pdf

Velocity

Multi-omic single-cell velocity models epigenome–transcriptome interactions and improves cell fate prediction https://github.com/welch-lab/MultiVelo

Generalizing RNA velocity to transient cell states through dynamical modeling https://github.com/theislab/scvelo

a scalable deep neural network that locally infers velocity for each cell from its neighbors https://github.com/GuangyuWangLab2021/cellDancer

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