intratumoral heterogeneity

"Importantly, ITH does not manifest exclusively at the genetic level, but encompasses epigenetic, transcriptional, phenotypic, metabolic, and secretory components3,4,5,6. ITH also affects nonmalignant compartments of the TME, including (but not limited to) cancer-associated fibroblasts (CAFs)8 and tumor-infiltrating lymphocytes (TILs)9,10,11, as well as various myeloid cell populations like tumor-associated macrophages (TAMs) and dendritic cells (DCs)12. " https://www.nature.com/articles/s41591-021-01233-9