Survey of Antisense Transcription

Citation: Ling, MHT. 2025. Survey of Antisense Transcription. In Ranganathan, S., Cannataro, M., and Khan, A. M. (eds), Encyclopedia of Bioinformatics and Computational Biology (2nd Edition) Volume 5, Pages 393-398. Oxford: Elsevier. ISBN 978-0-323-95503-4.

Link to [Abstract]

In recent years, many antisense transcripts had been discovered. Antisense transcripts are complementary to the coding transcripts, also known as sense transcripts. Duplex formation of sense/antisense transcript has been thought to limit the effective abundance of sense transcripts, leading to reduced levels of translated peptides/proteins. However, recent discoveries show that this is not the case – duplex formation is the first-order effect, which can affect higher-orders; such as, interfere with transcription and translation of sense transcripts, affecting the maturation and half-life of sense transcripts. In this article, 4 cases are examined in depth to illustrate that the effects of antisense transcript on the eventual peptide/protein level can be complex and should be considered on a case-by-case basis.